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Epidemiol Infect ; 136(3): 334-40, 2008 Mar.
Article in English | MEDLINE | ID: mdl-17445315

ABSTRACT

The objective of this study was to assess the impact of a possible unmeasured confounding variable in a previously published association between the effects of household water supply and positive results for hepatitis A serology. This was estimated using a path of integration between two methods of sensitivity analysis, called Rosenbaum's method and Greenland's external adjustment. The association between household water supply and positive results for hepatitis A (outcome) serology was insensitive to confounding unless the odds ratio for the association between the confounder and the outcome was > or = 4. The integration of the two sensitivity analysis methods presented proved useful when assessing the effects of a potential unmeasured confounder.


Subject(s)
Hepatitis A Antibodies/analysis , Hepatitis A virus/immunology , Hepatitis A/epidemiology , Water Supply , Brazil/epidemiology , Confounding Factors, Epidemiologic , Family Characteristics , Hepatitis A/blood , Hepatitis A/etiology , Hepatitis A/virology , Humans , Sensitivity and Specificity , Seroepidemiologic Studies
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