[The effect of metformin on lactate levels in type II diabetes]. / Vliv metforminu na hladiny laktátu u diabetiku II. typu.

The authors investigated the lactic acid levels in the blood of 57 type 2 diabetics treated with metformin. The mean lactate level before onset of metformin treatment was in the whole group 2.01 +/- 0.36 mmol/l and after 6 months of metformin administration it remained unchanged 2.00 +/- 0.42 mmol/l. Compensation of diabetes evaluated by HbAlc improved significantly (9.74 +/- 1.62% before treatment, and 8.52 +/- 1.36% after 6 months of treatment). The mean cholesterol levels declined significantly and the mean triacylglycerol levels were after two months of metformin administration significantly lower. Metformin treatment did not lead to an increase of the patients body weight.

[Levels of lactic acid in type II diabetics treated with buformin]. / Hladiny kyseliny mlécné u diabetiku II. typu lécených buforminem.

The objective of the work was to assess the blood lactate levels in type 2 diabetics selected at random, treated for prolonged periods with buformin. 77% of the investigated group of diabetics (N = 70) had elevated blood lactate levels and 16% of them had hyperlactataemia (more than 5.0 mmol/l). In 33% patients with an originally elevated lactataemia after 12 weeks of discontinued buformin treatment the lactic acid blood levels reached normal values. The lactate levels declined significantly (by more than 25% of the original value) after 6 weeks without buformin treatment in another 45% of the diabetic patients. In 18% of the investigated patients, who had high lactate levels even after discontinuation of treatment, in two-thirds neither impaired function of the kidneys and liver nor cardiac disease or alcoholism were detected.

[Follow-up of newly diagnosed patients with diabetes in the Prague population. II. Changes in the group of new diabetics after a 2-year follow-up]. / Sledování nove diagnostikovaných onemocnení cukrovkou v prazské populaci. II. cást: Zmeny v souboru nových diabetiku po dvouletém sledování.

From the total number of 1551 new diabetics and patients with PGT 85 subjects died in the course of two years. Treatment was changed 118 times, failure of PAD treatment was recorded in 11 type 2 diabetics. Three patients originally classified as type 1 were later included in type 2. In three diabetics (of 14) who had sings of diabetic retinopathy already during manifestation of DM marked deterioration of the finding on the fundus occurred. The incidence of macroangiopathic complications did not change.

[Follow-up of newly diagnosed patients with diabetes in the Prague population. I. Incidence of diabetes and disorders of glucose tolerance, methods of detection, complications]. / Sledování nove odhalených nemocných cukrovkou v prazské populaci. I. cást: Incidence cukrovky a poruch glukózové tolerance, zpusob odhalení, komplikace.

The authors followed up the incidence of new cases of diabetes in nine Prague diabetological clinics, the way of manifestation of diabetes and its detection, age dependence, seasonal character and incidence of complications. The incidence of type 2 diabetes was 269, of type 1 2.3 and impaired glucose tolerance 27 per 100,000 population. In 76% diabetes was detected accidentally, most frequently by the health community doctor or factory medical officer; 65% of the diabetes were older than 60 years. 51% suffered from hypertension and in 0.9% of type 2 diabetics retinopathy was found.

[The effect of Sinecal fiber on compensation in type 2 diabetics]. / Vliv vlákniny Sinecal na kompenzaci cukrovky u diabetiku 2. typu.

The authors investigated in 28 type 2 diabetics the effect of addition of 21 g Sinecal fibre to the normal diet on the glucose and lipid metabolism. The value of C,peptide was significantly influenced after breakfast and a single dose of Sinecal. The other investigated parameters (blood sugar on fasting and after a meal, glycosuria, glycosylated proteins, C-peptide on fasting and after a meal, triacylglycerol and cholesterol) were not influenced by a single nor by long-term intake of Sinecal. Further development of fibre preparations with better tolerance and a greater effect on the glucose metabolism is desirable.