The brain and the subjective experience of time. A voxel based symptom-lesion mapping study.

The aim of the study was to identify the anatomical bases involved in the subjective experience of time, by means of a voxel based symptom-lesion mapping (VLSM) study on patients with focal brain damage. Thirty-three patients (nineteen with right-hemisphere lesions -RBD, and fourteen with left lesion- LBD) and twenty-eight non-neurological controls (NNC) underwent the semi-structured QUEstionnaire for the Subjective experience of Time (QUEST) requiring retrospective and prospective judgements on self-relevant time intervals. All participants also completed tests to assess general cognitive functioning and two questionnaires to evaluate their emotional state. Both groups of brain-damaged patients achieved significantly different scores from NNC on the time performance, without differences between RBD and LBD. VLSM showed a cluster of voxels located in the right inferior parietal lobule significantly related to errors in the prospective items. The lesion subtraction analysis revealed two different patterns possibly associated with errors in the prospective items (the right inferior parietal cortex, rolandic operculum and posterior middle temporal gyrus) and in the retrospective items (superior middle temporal gyrus, white matter posterior to the insula).

Aging and the subjective experience of time.

BACKGROUND: The subjective experience of time involves several, not yet identified, mechanisms. Many cognitive and emotional factors, such as attention, memory and subjective mental states can influence time estimation. AIMS: We aimed to assess the subjective experience of time and its relationships with cognitive and emotional characteristics in the elderly. METHOD: Forty-nine non-demented patients hospitalized for orthopedic rehabilitation underwent an 'ecological' evaluation tool, the semi-structured QUEstionnaire for the Subjective experience of Time (QUEST) requiring retrospective and prospective judgements on self-relevant time intervals. All patients completed tests to assess general cognitive functioning and two questionnaires to evaluate emotional state. RESULTS: Results showed that accuracy in time estimation did not differ in young-old vs. old-old individuals: both groups performed better on prospective than on retrospective items and on highly than on poorly self-relevant items. Multiple regression analysis showed that performance on QUEST was significantly related to depression and hospitalization duration, but not to age, education, or neuropsychological scores. CONCLUSIONS: The influence of the emotional state is consistent with theories postulating that the "sense of time" is emergent from emotional and visceral states.