ABSTRACT
Three novel betaine alkaloids, called aminozooanemonin (1), pyridinebetaine A (2), and pyridinebetaine B (3), have been isolated from the Caribbean sponge Agelas dispar. Their structures were determined by FABMS, IR, UV, and 1D and 2D NMR spectroscopic experiments. Aminozooanemonin and pyridinebetaine A showed moderate antibacterial activity.
Subject(s)
Anti-Bacterial Agents/pharmacology , Betaine/analogs & derivatives , Porifera/chemistry , Animals , Bacteria/drug effects , Betaine/isolation & purification , Betaine/pharmacology , Chromatography, High Pressure Liquid , Magnetic Resonance Spectroscopy , Microbial Sensitivity Tests , Spectrometry, Mass, Fast Atom Bombardment , Spectrophotometry, Infrared , Spectrophotometry, UltravioletABSTRACT
Further investigation of the Caribbean marine sponge Agelas dispar for biologically active constituents has led to the isolation of the novel bromopyrrole alkaloids longamide B (1), and clathramides C (2) and D (3), whose structures have been determined by spectroscopic methods. Isolation of the known keramadine (4) and of the ecdysonic sterols ecdysterone (5) and ajugasterone C (6) is also reported. The antimicrobial activities of the isolated bromopyrrole alkaloids is summarized.
Subject(s)
Alkaloids/chemistry , Anti-Bacterial Agents/pharmacology , Porifera/chemistry , Alkaloids/pharmacology , Animals , Bacillus subtilis/drug effects , Chromatography, High Pressure Liquid , Microbial Sensitivity Tests , Spectrophotometry, Ultraviolet , Staphylococcus aureus/drug effectsABSTRACT
Hydrocarbons, triterpenoids and sterols were determined in Stenomesson variegatum (R. et P.) Macbr. (Amaryllidaceae), a plant used in traditional peruvian medicine as an antiinflammatory. An unusual presence of odd hydrocarbons was found, whereas triterpenoidic and sterolic fractions are quite usual and simple.
