ABSTRACT
INTRODUCTION: The incidence, characteristics, and prognosis of pulmonary embolism (PE) in Coronavirus disease 2019 (COVID-19) have been poorly investigated. We aimed to investigate the prevalence and the correlates with the occurrence of PE as well as the association between PE and the risk of mortality in COVID-19. METHODS: Retrospective multicenter study on consecutive COVID-19 patients hospitalized at 7 Italian Hospitals. At admission, all patients underwent medical history, laboratory and echocardiographic evaluation. RESULTS: The study population consisted of 224 patients (mean age 69 ± 14, male sex 62%); PE was diagnosed in 32 cases (14%). Patients with PE were hospitalized after a longer time since symptoms onset (7 IQR 3-11 days, 3 IQR 1-6 days; p = 0.001) and showed higher D-dimers level (1819 IQR 568-5017 ng/ml vs 555 IQR 13-1530 ng/ml; p < 0.001) and higher prevalence of myocardial injury (47% vs 28%, p = 0.033). At multivariable analysis, tricuspid annular plane systolic excursion (TAPSE; HR = 0.84; 95% CI 0.66-0.98; p = 0.046) and systolic pulmonary arterial pressure (sPAP; HR = 1.12; 95% CI 1.03-1.23; p = 0.008) resulted the only parameters independently associated with PE occurrence. Mortality rates (50% vs 27%; p = 0.010) and cardiogenic shock (37% vs 14%; p = 0.001) were significantly higher in PE as compared with non-PE patients. At multivariate analysis PE was significant associated with mortality. CONCLUSION: PE is relatively common complication in COVID-19 and is associated with increased mortality risk. TAPSE and sPAP resulted the only parameters independently associated with PE occurrence in COVID-19 patients.
Subject(s)
COVID-19/epidemiology , Pulmonary Embolism/epidemiology , Aged , Aged, 80 and over , COVID-19/diagnosis , COVID-19/mortality , COVID-19/therapy , Female , Humans , Hypertension, Pulmonary/epidemiology , Italy/epidemiology , Male , Middle Aged , Prevalence , Prognosis , Pulmonary Embolism/diagnosis , Pulmonary Embolism/mortality , Pulmonary Embolism/therapy , Registries , Retrospective Studies , Risk Assessment , Risk Factors , Ventricular Dysfunction, Right/epidemiologyABSTRACT
Congestive heart failure secondary to myocardial infarction is associated with significant morbidity and mortality despite currently available therapies. A novel catheter-based left ventricular partitioning device (ParachuteTM, CardioKinetix, Inc., Menlo Park, CA) is currently available for the treatment of patients with severe systolic dysfunction after antero-apical myocardial infarction with regional wall motion abnormalities. Preliminary clinical data showed that the ParachuteTM implantation could be associated with favorable clinical and left ventricular hemodynamic improvements post-implantation. Here, we present the case of a patient with symptomatic congestive heart failure after myocardial infarction implanted with the ParachuteTM device and we briefly review the current literature on this left ventricular partitioning system.
