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1.
Vet Pathol ; 52(2): 344-50, 2015 Mar.
Article in English | MEDLINE | ID: mdl-24782390

ABSTRACT

A diffuse, chronic, superficial neocortical degeneration that resulted in atrophy was detected in five 1 to 2-year-old-dogs. Presenting neurologic signs included ataxia, dysphagia, blindness, and mentation changes. Magnetic resonance imaging on brains from 2 dogs demonstrated severe bilateral cerebrocortical atrophy and enlarged lateral and third ventricles. Grossly, multifocal, bilaterally symmetrical, extensive areas of neocortical brownish discoloration associated with atrophy of gyri and sulcal widening were recorded in the dorsal and lateral cerebral hemispheres in 3 dogs. Microscopically, in all dogs there was subacute to chronic superficial neocortical degeneration affecting all cerebral lobes, ranging from loss of the molecular layer to less frequent larger and deeper cavitations of variable size. Clinical signs probably resulted from a combination of primary neocortical degeneration and secondary degeneration in the corticobulbar and corticospinal tracts. The distribution pattern of gross and histologic cerebrocortical lesions suggests that this is a novel degenerative canine cerebral disease.


Subject(s)
Ataxia/veterinary , Dog Diseases/pathology , Neocortex/pathology , Animals , Ataxia/pathology , Atrophy/pathology , Atrophy/veterinary , Brain/pathology , Dogs , Female , Magnetic Resonance Imaging/veterinary , Male
2.
Equine Vet J ; 47(5): 568-72, 2015 Sep.
Article in English | MEDLINE | ID: mdl-24917312

ABSTRACT

REASONS FOR PERFORMING STUDY: Acorn toxicity has been anecdotally reported to cause fatal colitis and colic in horses but reports in the scientific literature are sparse. OBJECTIVES: This study reports the diagnosis, treatment, prognosis and outcome of 9 cases with suspected acorn toxicity admitted to 2 referral hospitals. STUDY DESIGN: Retrospective case series. METHODS: Case records from 2004 to 2013 were reviewed. Horses were included in the study if they met 3 of 4 criteria: exposure to acorns; clinical and laboratory data suggesting alimentary or renal dysfunction; acorn husks in the faeces or gastrointestinal tract; and necropsy and histopathological findings consistent with acorn toxicity. Data collected included case history, clinical presentation, clinicopathological data, ultrasonographic findings, case progression, and necropsy and histopathological findings. RESULTS: Nine horses met the inclusion criteria. Five cases presenting with haemorrhagic diarrhoea deteriorated rapidly and were subjected to euthanasia or died. Four cases showed signs of colic with gas distension, displacement of the large colon and diarrhoea. Three of these (33%) survived with medical management, the fourth was subjected to euthanasia. Post mortem examination of 6 cases demonstrated submucosal oedema of the large intestine and caecum (n = 6), acute tubular nephrosis (n = 6), diffuse necrohaemorrhagic and ulcerative typhlocolitis and enteritis (n = 4), and small intestinal oedema (n = 3). CONCLUSIONS: Acorn ingestion may be associated with typhylocolitis leading to diarrhoea, colic and acute renal tubular nephrosis. Recovery is possible in mildly affected cases; more severe cases show hypovolaemia, intractable pain, renal dysfunction and cardiovascular failure, and often succumb to the disease process. Disease is only seen in a small proportion of the population exposed to acorns and there seems to be an increased occurrence in certain years. Further investigation into factors predisposing to disease is required, but limiting exposure to acorns in the autumn seems prudent.


Subject(s)
Colic/veterinary , Colitis/chemically induced , Colitis/veterinary , Horse Diseases/chemically induced , Quercus/toxicity , Seeds/toxicity , Animals , Colic/chemically induced , Colic/pathology , Colitis/pathology , Female , Horse Diseases/pathology , Horses , Male , Plants, Toxic , Retrospective Studies
3.
J Small Anim Pract ; 54(10): 555-8, 2013 Oct.
Article in English | MEDLINE | ID: mdl-23724782

ABSTRACT

An eight-year-old, neutered, male German short-haired pointer was presented for a chronic cough and an intrathoracic mass. Computed tomography revealed a mass with low attenuation in the right caudal lung lobe that invaded the principal bronchi. The mass was removed by right caudal and accessory lung lobectomy. The histopathological diagnosis was pulmonary lipoma. The clinical signs resolved following surgery. There was no evidence of recurrence or de novo lesions on computed tomography performed 12 months post-surgery. To the authors' knowledge, this is the first report of a pulmonary lipoma in a dog.


Subject(s)
Dog Diseases/diagnosis , Lipoma/veterinary , Lung Neoplasms/veterinary , Animals , Dog Diseases/pathology , Dog Diseases/surgery , Dogs , Lipoma/diagnosis , Lipoma/pathology , Lipoma/surgery , Lung/pathology , Lung/surgery , Lung Neoplasms/diagnosis , Lung Neoplasms/pathology , Lung Neoplasms/surgery , Male , Tomography, X-Ray Computed/veterinary
4.
J Small Anim Pract ; 54(3): 153-5, 2013 Mar.
Article in English | MEDLINE | ID: mdl-23190147

ABSTRACT

Prevotella oralis, an obligate Gram-negative anaerobe, was detected as the cause of acute meningitis in a four-year-old cocker spaniel. Clinical signs included acute onset collapse and severe depression. Despite treatment, the animal died. A post-mortem examination was performed which revealed a fibrinosuppurative meningitis with no significant inflammation of the brain or spinal parenchyma. The aetiological diagnosis was confirmed by anaerobic bacterial culture. This report discusses the nature and extent of the lesions and possible routes of infection of the causative organism.


Subject(s)
Bacteroidaceae Infections/veterinary , Dog Diseases/diagnosis , Meningitis, Bacterial/veterinary , Prevotella , Animals , Bacteroidaceae Infections/diagnosis , Dogs , Fatal Outcome , Female , Meningitis, Bacterial/diagnosis
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