Delayed Diagnosis of Mycobacteriumbovisbacillus Calmette-Guérin Periprosthetic Joint Infection Following Total Knee Arthroplasty.

Periprosthetic joint infection (PJI) can present challenges in diagnosis and treatment, particularly in the setting of atypical causative organisms such as fungi and mycobacteria. Herein, we present a case and provide a review of the diagnosis and treatment of an unusual PJI caused by bacillus Calmette-Guérin, administered during the treatment of bladder cancer 3 years prior to total knee arthroplasty and subsequent PJI. Although the patient's history of bladder cancer was known, neither his Bacillus Calmette-Guérin treatment nor its potential for distant site spread that could lead to PJI were appreciated, leading to a prolonged diagnostic evaluation and treatment course.

Learning Introductory Biology: Students' Concept-Building Approaches Predict Transfer on Biology Exams.

Previous studies have found that students' concept-building approaches, identified a priori with a cognitive psychology laboratory task, are associated with student exam performances in chemistry classes. Abstraction learners (those who extract the principles underlying related examples) performed better than exemplar learners (those who focus on memorizing the training exemplars and responses) on transfer exam questions but not retention questions, after accounting for general ability. We extended these findings to introductory biology courses in which active-learning techniques were used to try to foster deep conceptual learning. Exams were constructed to contain both transfer and retention questions. Abstraction learners demonstrated better performance than exemplar learners on the transfer questions but not on the retention questions. These results were not moderated by indices of crystallized or fluid intelligence. Our central interpretation is that students identified as abstraction learners appear to construct a deep understanding of the concepts (presumably based on abstract underpinnings), thereby enabling them to apply and generalize the concepts to scenarios and instantiations not seen during instruction (transfer questions). By contrast, other students appear to base their representations on memorized instructed examples, leading to good performance on retention questions but not transfer questions.

The novel use of a spray-on rubber coating to recover cellular material from the surface of bricks.

Currently, forensic investigators utilise various types of swabs and tape lifts to recover cellular material from coarse surfaces identified during a criminal investigation. However, a number of challenges prevent successful recovery and therefore warrants the need for an alternative method. Plasti dip® is peel-off rubber coating that can be applied to most surfaces and may have an application in the recovery of DNA from coarse surfaces. The aim of this study was to determine the effectiveness of Plasti dip® to recover DNA from coarse brick surfaces and assess how this method compares to current techniques. Cellular material was deposited onto brick pieces in varying concentrations and recovered with either flocked, foam or rayon swabs, or Plasti dip®. Material recovered, using each technique, was extracted and quantitated for comparison of DNA yields. At low and medium cell concentrations, an observable but not statistically significant difference was observed between the swabbing methods and Plasti dip®. At high cell concentrations Plasti dip® was able to recover a significantly higher DNA concentration than all three swabbing methods. Quantitation results indicated no degradation of DNA. This is a novel approach to the collection of trace DNA from surfaces that have historically proven difficult to sample. While there is further validation required, this landmark study demonstrates the potential that spray-on rubber coatings have for casework involving rough, porous surfaces like bricks, stones or rocks.

Using Students' Concept-building Tendencies to Better Characterize Average-Performing Student Learning and Problem-Solving Approaches in General Chemistry.

We previously reported that students' concept-building approaches, identified a priori using a cognitive psychology laboratory task, extend to learning complex science, technology, engineering, and mathematics topics. This prior study examined student performance in both general and organic chemistry at a select research institution, after accounting for preparation. We found that abstraction learners (defined cognitively as learning the theory underlying related examples) performed higher on course exams than exemplar learners (defined cognitively as learning by memorizing examples). In the present paper, we further examined this initial finding by studying a general chemistry course using a different pedagogical approach (process-oriented guided-inquiry learning) at an institution focused on health science majors, and then extended our studies via think-aloud interviews to probe the effect concept-building approaches have on problem-solving behaviors of average exam performance students. From interviews with students in the average-achieving group, using problems at three transfer levels, we found that: 1) abstraction learners outperformed exemplar learners at all problem levels; 2) abstraction learners relied on understanding and exemplar learners dominantly relied on an algorithm without understanding at all problem levels; and 3) both concept-building-approach students had weaknesses in their metacognitive monitoring accuracy skills, specifically their postperformance confidence level in their solution accuracy.

Participation in Voluntary Re-quizzing Is Predictive of Increased Performance on Cumulative Assessments in Introductory Biology.

Low-stakes testing, or quizzing, is a formative assessment tool often used to structure course work. After students complete a quiz, instructors commonly encourage them to use those quizzes again to retest themselves near exam time (i.e., delayed re-quizzing). In this study, we examine student use of online, ungraded practice quizzes that are reopened near exam time after a first graded attempt 1-3 weeks prior. We find that, when controlling for preparation (performance in a previous science, technology, engineering, and mathematics [STEM] course and incoming biology knowledge), re-quizzing predicts better performance on two cumulative exams in introductory biology: a course posttest and final exam. Additionally, we describe a preliminary finding that, for the final exam, but not the posttest, re-quizzing benefits students with lower performance in a previous STEM course more than their higher-performing peers. But unfortunately, these struggling students are also less likely to participate in re-quizzing. Together, these data suggest that a common practice, reopening quizzes for practice near exam time, can effectively benefit student performance. This study adds to a growing body of literature that suggests quizzing can be used as both an assessment tool and a learning tool by showing that the "testing effect" extends to delayed re-quizzing within the classroom.

The PULSE Vision & Change Rubrics, Version 1.0: A Valid and Equitable Tool to Measure Transformation of Life Sciences Departments at All Institution Types.

The PULSE Vision & Change Rubrics, version 1.0, assess life sciences departments' progress toward implementation of the principles of the Vision and Change report. This paper reports on the development of the rubrics, their validation, and their reliability in measuring departmental change aligned with the Vision and Change recommendations. The rubrics assess 66 different criteria across five areas: Curriculum Alignment, Assessment, Faculty Practice/Faculty Support, Infrastructure, and Climate for Change. The results from this work demonstrate the rubrics can be used to evaluate departmental transformation equitably across institution types and represent baseline data about the adoption of the Vision and Change recommendations by life sciences programs across the United States. While all institution types have made progress, liberal arts institutions are farther along in implementing these recommendations. Generally, institutions earned the highest scores on the Curriculum Alignment rubric and the lowest scores on the Assessment rubric. The results of this study clearly indicate that the Vision & Change Rubrics, version 1.0, are valid and equitable and can track long-term progress of the transformation of life sciences departments. In addition, four of the five rubrics have broad applicability and can be used to evaluate departmental transformation by other science, technology, engineering, and mathematics disciplines.

The curious case of orthographic distinctiveness: Disruption of categorical processing.

How does orthographic distinctiveness affect recall of structured (categorized) word lists? On one theory, enhanced item-specific information (e.g., more distinct encoding) in concert with robust relational information (e.g., categorical information) optimally supports free recall. This predicts that for categorically structured lists, orthographically distinct (OD) word lists should be recalled better than orthographically common (OC) word lists. Another possibility is that OD items produce a far-reaching impairment in relational processing, including that of categorical information. This view anticipates an advantage in recall for OC items relative to OD lists. In Experiment 1 categorically structured OC lists produced better recall performance and higher clustering than did categorically structured OD lists. When words were presented in capital letters, thereby minimizing orthographic distinctiveness, OC and OD lists showed equivalent recall and category clustering (Experiment 2). When recall was cued with category labels, OC items were still better recalled than OD items (Experiment 3). These patterns, along with category access and items-per-category recalled, are consistent with the interpretation that orthographic distinctiveness creates a disruption in encoding of inter-item associations within a category. This interpretation expands previous work indicating that orthographic distinctiveness disrupts encoding of serial order information, another kind of inter-item association. (PsycINFO Database Record

Individual differences in learning and transfer: stable tendencies for learning exemplars versus abstracting rules.

We hypothesize that during training some learners may focus on acquiring the particular exemplars and responses associated with the exemplars (termed exemplar learners), whereas other learners attempt to abstract underlying regularities reflected in the particular exemplars linked to an appropriate response (termed rule learners). Supporting this distinction, after training (on a function-learning task), participants displayed an extrapolation profile reflecting either acquisition of the trained cue-criterion associations (exemplar learners) or abstraction of the function rule (rule learners; Studies 1a and 1b). Further, working memory capacity (measured by operation span [Ospan]) was associated with the tendency to rely on rule versus exemplar processes. Studies 1c and 2 examined the persistence of these learning tendencies on several categorization tasks. Study 1c showed that rule learners were more likely than exemplar learners (indexed a priori by extrapolation profiles) to resist using idiosyncratic features (exemplar similarity) in generalization (transfer) of the trained category. Study 2 showed that the rule learners but not the exemplar learners performed well on a novel categorization task (transfer) after training on an abstract coherent category. These patterns suggest that in complex conceptual tasks, (a) individuals tend to either focus on exemplars during learning or on extracting some abstraction of the concept, (b) this tendency might be a relatively stable characteristic of the individual, and (c) transfer patterns are determined by that tendency.

Resource depletion does not influence prospective memory in college students.

This paper reports an experiment designed to investigate the potential influence of prior acts of self-control on subsequent prospective memory performance. College undergraduates (n=146) performed either a cognitively depleting initial task (e.g., mostly incongruent Stroop task) or a less resource-consuming version of that task (e.g., all congruent Stroop task). Subsequently, participants completed a prospective memory task that required attentionally demanding monitoring processes. The results demonstrated that prior acts of self-control do not impair the ability to execute a future intention in college-aged adults. We conceptually replicated these results in three additional depletion and prospective memory experiments. This research extends a growing number of studies demonstrating the boundary conditions of the resource depletion effect in cognitive tasks.

Cognitive exertion and subsequent intention execution in older adults.

OBJECTIVES: Previous studies have demonstrated that increasing the demands of a prospective memory task is detrimental to older adults' performance; however, no studies have investigated how prior cognitive demands influence subsequent prospective memory. The present study sought to address this gap by using a resource depletion paradigm. METHODS: A sample of 107 older adults whose ages ranged from 60 to 85 years (M=71.91, SD=7.12) completed an initial task that was either cognitively taxing or relatively easy followed by either an attention-demanding prospective memory task or one that required minimal attentional resources. RESULTS: Initial cognitive exertion led to decrements in prospective memory performance in the attention-demanding situation, particularly for the old-old participants (age≥72); however, prior cognitive exertion did not influence subsequent prospective memory performance when the prospective memory task required minimal attentional resources. DISCUSSION: This study extends the negative effects of prior cognitive exertion to prospective memory in older adults. Also, dovetailing with past work, the depletion effects were limited to prospective memory tasks that are thought to require demanding attentional processes. The depletion effects were most pronounced for the old-old, suggesting that increased age may be associated with decline in attentional resources.