ABSTRACT
Objective: To investigate the functional lateralization of major Chinese language cortex in patients with cerebral arteriovenous malformation (AVM) in dominant hemispheric via functional magnetic resonance imaging (fMRI). Methods: Nine right-handed normal volunteers and fourteen patients with cerebral AVM in dominant hemisphere diagnosed in Beijing Tiantan Hospital between December 2017 and June 2018 were included. Three language tasks (semantic judgment, word reading, and listening comprehension) were applied to activate language areas. Lateralization index (LI) was used to show the dominant hemisphere. Results: In the control group, right-sided lateralization of BOLD signal activations was observed in 0/27 (0%) of the language tasks. While in the AVM patients, right-sided lateralization of BOLD signal activations was observed in 8/42 (19%) language tasks. The difference was statistically significant (χ(2)=5.73, P=0.019). Conclusions: The dominant hemisphere of different language tasks may be different in patients with cerebral lesions. Compared with normal controls, patients with cerebral AVM in dominant hemispheric are more likely to have right-sided lateralization of language cortex.
Subject(s)
Language , Neurosurgery , Brain Mapping , Cerebral Cortex , Functional Laterality , Humans , Magnetic Resonance ImagingABSTRACT
The content of liensinine in the green seed embryo of Nelumbo nucifera was determined by dual-wavelength TLC-scanning. The crude drug was extracted with two different method of impregnating and refluxing. The content of liensinine was determined to be 0.853% and 0.939% and the average recovery was 97.9% and 100.9% respectively.
Subject(s)
Drugs, Chinese Herbal/chemistry , Isoquinolines/analysis , Phenols/analysis , Chromatography, Thin Layer , Densitometry , Seeds/chemistryABSTRACT
Monitoring of serum concentration and studying of individual clinical pharmacokinetics of phenytoin (PHT) were made in 15 patients with refractory epilepsy who had taken PHT and other antiepileptic drugs for a long time. The results showed that 10 of them were tolerant to PHT and their effective doses were higher than the routine ones; 2 of them showed striking fluctuation of serum PHT concentration within 24 hours; In the remaining patients serum PHT concentration during menstruation was much lower than that during ovulation. According to their different characteristics we gave them reasonable and individualized adjustment in dose and time interval of taking PHT. The seizures of all the patients were controlled satisfactorily. It is suggested that some of the patients with refractory epilepsy may have special PHT pharmacokinetics.
