ABSTRACT
Three novel organotin complexes with general formula Sn(OH)(bz)(2)L (bz = benzyl, HL = 2-, 3-, or 4-(1-oxo-1H-2,3-dihydroisoindol-2-yl)benzoic acid) and one of their ligands were prepared and characterized. In vitro antifungal and antibacterial activities of these complexes and ligands were investigated with the representative strains of Candida albicans, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Their fluorescence properties have also been discussed.
Subject(s)
Anti-Bacterial Agents/chemical synthesis , Antifungal Agents/chemical synthesis , Benzoates/chemistry , Coordination Complexes/chemical synthesis , Fluorescent Dyes/chemistry , Organotin Compounds/chemistry , Anti-Bacterial Agents/chemistry , Anti-Bacterial Agents/pharmacology , Antifungal Agents/chemistry , Antifungal Agents/pharmacology , Candida albicans/drug effects , Coordination Complexes/chemistry , Coordination Complexes/pharmacology , Escherichia coli/drug effects , Isoindoles , Microbial Sensitivity Tests , Pseudomonas aeruginosa/drug effects , Staphylococcus aureus/drug effectsABSTRACT
In the title complex, [CoCl(2)(C(12)H(8)N(2))(2)]·C(3)H(7)NO, which has twofold rotation symmetry, the Co(II) cation is coordinated by two 1,10-phenanthroline (phen) mol-ecules and two chloride ligands in a distorted octa-hedral geometry. In the crystal structure, a cavity is created by six complex mol-ecules connected by C-Hâ¯π inter-actions and non-classical C-Hâ¯Cl hydrogen bonds. The cavities are occupied by the disordered dimethyl-formamide solvent mol-ecule. The C and N atoms of the C-N bond in the solvent mol-ecule also lie on a crystallographic twofold rotation axis; the remaining atoms of the solvent are statistically disordered (ratio 0.5:0.5) about this axis.
