ABSTRACT
Nanocavity biomaterials with recognition specificity imprinted by using proteins as templates may successful serve as substitutes for antibodies, enzymes, and other native biological structures as well as cell bracket materials. It has numerous applications in biotechnology, medicine and so on. In this paper, the principle of template imprinting is introduced briefly, the specialty of template imprinting of proteins is analyzed, and the methods of template imprinting of proteins including protein entrapment, microbead surface imprinting, flat surface imprinting as well as the epitope are reviewed in details.
Subject(s)
Biocompatible Materials/chemical synthesis , Nanotechnology , Templates, Genetic , Animals , Biotechnology , Genomic Imprinting , Humans , Macromolecular Substances , Peptides/chemical synthesis , Polymers , Proteins/chemical synthesisABSTRACT
Micro- and nano-structured surfaces of scaffold materials have important effects on cells' adhesion and proliferation. Nano-structured surfaces can improve cells' adhesion and biocompatibility of materials. The effects of nano-biomaterials on the development of tissue engineering and the methods of preparation of nano-biomaterials such as molecular self-assemble and template technology are discussed.
