1.
Chem Commun (Camb)
; 58(11): 1697-1700, 2022 Feb 03.
Article
in English
| MEDLINE
| ID: mdl-35022626
ABSTRACT
There is continued interest in developing cascade processes for the synthesis of key chiral building blocks and bioactive natural products (or analogues). Here, we report a hybrid bio-organocatalytic cascade for the synthesis of a small panel of 2-substituted piperidines, relying on a transaminase to generate a key reactive intermediate for the complexity building Mannich reaction.