ABSTRACT
BACKGROUND: Simulation is an important learning-teaching tool for integrating theory and practice in nursing education. OBJECTIVE: The aim of this study was to develop and to conduct the validity and reliability of a self-evaluation scale for simulation laboratory practices (SES-SLP) with undergraduate nurses. METHODS: The study sample consisted of 220 undergraduate nursing students. Data were collected using a Descriptive Characteristic Form (DCF) and the 23-item Self-Evaluation Scale for Simulation Laboratory Practices (SES-SLP). RESULTS: Cronbach's alpha value of the scale was 0.94. The scale comprised of two subscales: the developing factor (19 items) and the challenging factor (4 items). All items showed a statistically significant correlation (p < 0.05). CONCLUSIONS: The SES-SLP is a valid and reliable scale that can be used to evaluate students' learning experience for simulation laboratory practices.
Subject(s)
Education, Nursing, Baccalaureate , Students, Nursing , Diagnostic Self Evaluation , Humans , Laboratories , Psychometrics , Reproducibility of Results , Surveys and QuestionnairesABSTRACT
In continuation of our efforts to develop new derivatives as hepatitis C virus (HCV) NS5B inhibitors, we synthesized novel 5-arylidene-4-thiazolidinones. The novel compounds 29-42, together with their synthetic precursors 22-28, were tested for HCV NS5B inhibitory activity; 12 of these compounds displayed IC50 values between 25.3 and 54.1 µM. Compound 33, an arylidene derivative, was found to be the most active compound in this series with an IC50 value of 25.3 µM. Molecular docking studies were performed on the thumb pocket-II of NS5B to postulate the binding mode for these compounds.
