ABSTRACT
INTRODUCTION: Alcohol consumption is frequently associated with gastric mucosal lesions. The purpose of this study was to determine the effect of Coenzyme-Q10 (CoQ10) supplementation on the ethanol-induced gastric mucosal damage in a rat model. MATERIAL AND METHOD: Sixty-four female wistar albino rats were randomly divided into 8 groups (n = 8). Studies were performed in ethanol induced gastric ulcer model in Wistar albino rats. Famotidine at a dose of 5 mg/kg or 20 mg/kg and CoQ10 at a single dose of 10 mg/kg or 20 mg/kg and 30 mg/kg for 7 days were administered as pretreatment. All the rats in study groups received 2 ml/kg ethanol 95 % intragastrically, 30 minutes after pretreatment. Four hour after ethanol administration, all rats were sacrificed and their stomachs were removed under ketamin anaesthesia. Gastric protection was evaluated by measuring the ulcer index, MDA concentrations, and histopathological studies. RESULTS AND DISCUSSION: Rats pretreated either with famotidine or CoQ10 had significantly diminished gastric mucosal damage which was assessed with gross and microscopic analysis (p < 0.00625). MDA levels were significantly lower in famotidine 20 mg/kg and CoQ10 pretreatment for 7 days group (p < 0.00625).
Subject(s)
Anti-Ulcer Agents/pharmacology , Gastric Mucosa/drug effects , Stomach Ulcer/prevention & control , Ubiquinone/analogs & derivatives , Vitamins/pharmacology , Animals , Dose-Response Relationship, Drug , Ethanol , Female , Gastric Mucosa/pathology , Plant Extracts/pharmacology , Random Allocation , Rats , Rats, Wistar , Stomach Ulcer/chemically induced , Ubiquinone/pharmacologySubject(s)
Endoscopy, Gastrointestinal , Larynx, Artificial , Aged , Foreign Bodies/diagnosis , Humans , Laryngeal Neoplasms/surgery , Laryngectomy , MaleSubject(s)
Capsule Endoscopy/adverse effects , Foreign Bodies/surgery , Intestinal Obstruction/surgery , Intestine, Small , Colectomy , Crohn Disease/complications , Crohn Disease/surgery , Female , Fluoroscopy , Humans , Ileum/surgery , Intestinal Obstruction/etiology , Intestine, Small/surgery , Middle Aged , Postoperative Complications/etiology , Postoperative Complications/surgery , Tissue AdhesionsABSTRACT
OBJECTIVE: The aim of this study was to assess the factors that might predict patients at increased risk for inadvertent parathyroidectomy and postoperative symptomatic hypocalcemia during thyroidectomy. METHODS: Demographic data as well as the data on preoperative diagnosis, preoperative ultrasonography reports, operation reports, histological findings, and postoperative symptomatic hypocalcemia were collected. A total of 273 (83 male and 190 female patients) thyroid operations were included in this study. RESULTS: Histopathological examination identified inadvertent parathyroidectomy in 10 (3.7%) cases. Statistical analysis identified the presence of cervical lymphadenopathy as detected by preoperative ultrasonography as a risk factor for inadvertent parathyroidectomy. In 57 patients (20.9%) clinically symptomatic postoperative hypocalcemia was observed. However, the difference in the frequency of such hypocalcemia between the patients with and without inadvertent parathyroidectomy was not significant. Statistical evaluation identified total thyroidectomy as a risk factor for postoperative hypocalcemia (p<0.005). CONCLUSION: Due to our experience, inadvertent parathyroidectomy is not a rare entity during thyroidectomy and the presence of cervical lymphadenopathy, as observed by preoperative ultrasonography, is the only risk factor for inadvertent parathyroidectomy. In contrast, no association between inadvertent parathyroidectomy and postoperative hypocalcemia was detected. Total thyroidectomy was found to be the sole risk factor for symptomatic temporary hypocalcemia.
Subject(s)
Hypocalcemia/etiology , Intraoperative Complications , Parathyroidectomy , Thyroidectomy/adverse effects , Adult , Aged , Female , Humans , Lymph Nodes/diagnostic imaging , Lymphatic Diseases/complications , Lymphatic Diseases/surgery , Male , Middle Aged , Neck , Retrospective Studies , Risk Factors , Thyroid Diseases/surgery , UltrasonographyABSTRACT
BACKGROUND: Postoperative fluid collection in the space left behind the dissected hernia sac in laparoscopic herniorraphy puts the surgeon in a dilemma as to whether it is a recurrence or a seroma, and it is not always easily judged only by physical examination (PE). Another important issue is what kind of seroma can be accepted as a complication of surgery. METHODS: Thirty patients with unilateral inguinal hernia who had a hernia sac of >4 cm were operated on with transabdominal preperitoneal hernia repair (TAPP) technique and the collection at the hernia site was followed by PE and superficial ultrasonography (USG) postoperatively on the first day, first week, first month, and third month. RESULTS: USG detected seroma in 20 patients, while 17 could be noticed by PE on the first postoperative day. At the end of the third month, seromas resolved by 90%, and could only be detected by USG in two patients. Pain or complication rates attributable to seroma in patients were not determined (p > 0.05) in the statistical analyses between the groups. CONCLUSIONS: Superficial USG is a beneficial tool in differentiating early recurrence or seroma in patients. It should not be intervened with as a complication until the patient has complaints attributable to seroma.
