Subject(s)
COVID-19 , Heparin , Anticoagulants/therapeutic use , Enoxaparin , Heparin/therapeutic use , Hospitals , HumansABSTRACT
Many circulating markers are already in clinical practice and in experimental use for the diagnosis, therapeutic monitoring, and in the follow-up of ovarian cancer. The cancer antigen-125 (CA-125) has shown to be useful in epithelial ovarian cancer, but its specificity is too low for the test to be used as a primary screening technique in early stage and particularly in premenopausal women. In the last few years, several studies have focused on using the serial measurement of complementary serum markers to improve the positive predictive value and diagnostic accuracy. The main problem is that the different cellular lines express these markers in a very variable way.
Subject(s)
Biomarkers, Tumor/blood , Carcinoma/diagnosis , Ovarian Neoplasms/diagnosis , Antigens, Neoplasm/blood , CA-125 Antigen/blood , Carcinoembryonic Antigen/blood , Carcinoma/blood , Female , Glycoproteins/blood , Humans , Ovarian Neoplasms/blood , Tissue Polypeptide Antigen/bloodABSTRACT
Myoepithelial carcinoma or malignant myoepithelioma are considered extremely rare malignant salivary gland neoplasms. Their clinical behaviour by literature seems variable: most studies reported good prognosis for low-grade malignancy and vice versa. Nevertheless long term survival has been described in patients with high-grade tumours, while patients with low-grade have been reported to develop metastases. We report a case of myoepithelial carcinoma of the parotid gland arising in pleomorphic adenoma in a 52-year-old woman with favourable course in long term follow-up.
Subject(s)
Myoepithelioma/pathology , Parotid Neoplasms/pathology , Female , Humans , Middle AgedABSTRACT
Lichen planus of the oral mucosa (OLP) is characterized by lymphocytic infiltrate in the epithelial layer and basal cells lysis. Some studies have suggested a high incidence of oral squamous cell carcinoma in patients with OLP that has been implicated as a premalignant lesion. We describe 19 cases of OLP, and the immunopathologic basis for OLP, its potential association with malignancy and the variable clinical pictures in patients with OLP are reviewed. Also, specific recommendations are given for treatment and follow-up of lesions.
Subject(s)
Lichen Planus, Oral/pathology , Adult , Aged , Atrophy/pathology , Biopsy , Female , Humans , Male , Middle Aged , Mouth Mucosa/pathologyABSTRACT
Testis tumour is relatively rare and more frequent between 15-35 years of age. The 90% of this tumour derivates from germinal cells, the remaining cases originate from stromal cells or are secondary lesions from other neoplasms. The present clinical use of serum markers, especially alfa-fetoprotein (AFP), human chorionic gonadotrophin protein (HCG) and serum lactate dehydrogenase (LDH) is examined.
