ABSTRACT
The fertility of 70 men with Crohn's disease and a group of age matched controls were compared. Crohn's disease was associated with a significant reduction in family size independent of steroid or sulphasalazine treatment.
Subject(s)
Crohn Disease/complications , Infertility, Male/etiology , Adrenal Cortex Hormones/adverse effects , Adult , Aged , Crohn Disease/drug therapy , Family Characteristics , Humans , Infertility, Male/chemically induced , Male , Marriage , Middle Aged , Sulfasalazine/adverse effectsABSTRACT
Treatment of duodenal ulcer with the H2-receptor antagonist ranitidine, 150 mg twice daily has been assessed in a double-blind, placebo controlled study at seven centres in the United Kingdom. One hundred-and-twenty-nine patients entered the trial with endoscopically confirmed duodenal ulcer. Five patients did not comply with the protocol and were excluded from the analysis. Nine patients (1 ranitidine, 8 placebo) did not complete the initial 4 weeks' treatment due to poor symptomatic response; one hundred-and-fifteen (58 ranitidine, 57 placebo) were endoscopically assessed after 4 weeks. The average 4-week healing rate among patients on ranitidine (83%) was significantly greater than that for the placebo group (32%, p less than 0.01). Forty-four patients whose ulcers had not healed received further treatment with ranitidine 150 mg b.d. on an open basis. After a total of up to 8 weeks' active treatment only three patients had not healed. Ulcer symptoms resolved or improved in a greater proportion of patients on ranitidine, and this was associated with a significantly lower antacid consumption. There was no serious unwanted effect associated with ranitidine treatment, and the twice daily dose of 150 mg is apparently a safe and effective short-term treatment for duodenal ulceration.
Subject(s)
Duodenal Ulcer/drug therapy , Furans/therapeutic use , Histamine H2 Antagonists/therapeutic use , Adult , Aged , Antacids/therapeutic use , Clinical Trials as Topic , Double-Blind Method , Female , Humans , Male , Middle Aged , Ranitidine , United KingdomSubject(s)
Cromolyn Sodium/therapeutic use , Proctitis/drug therapy , Administration, Oral , Adolescent , Adult , Aged , Chronic Disease , Clinical Trials as Topic , Cromolyn Sodium/administration & dosage , Double-Blind Method , Drug Evaluation , Enema , Eosinophils , Female , Humans , Leukocyte Count , Male , Middle Aged , Placebos , Proctitis/pathology , Rectum/pathologyABSTRACT
Rectal-biopsy specimens were obtained from a group of patients with proctitis in different stages of activity. Large numbers of brightly fluorescent IgE-producing cells were demonstrated in rectal-biopsy specimens taken from these patients during disease activity and clinical remission. An immediate hypersensitivity reaction is suggested as one of the mechanisms involved in the pathogenesis of proctitis.
Subject(s)
Immunoglobulin E , Intestinal Mucosa/immunology , Proctitis/immunology , Rectum/immunology , Biopsy , Humans , Hypersensitivity, Immediate , Immunoglobulin A/isolation & purification , Immunoglobulin E/isolation & purification , Immunoglobulin G/isolation & purification , Immunoglobulin M/isolation & purificationABSTRACT
The effect of topical disodium cromoglycate (DSCG) has been examined in 30 patients with chronic active proctitis using a double-blind crossover trial. Each treatment period was four weeks and patients were given DSCG 200 mg by enema twice daily and 100 mg orally three times each day. Twenty-six patients completed the trial successfully, 14 responded to DSCG treatment, two improved with placebo, and 10 responded to neither. Patients who responded to DSCG had significantly more eosinophils in their rectal biopsies than those who failed to respond and in some instances the counts were very high. The findings support the hypothesis than an allergic reaction is important in the pathogenesis of proctitis.
Subject(s)
Cromolyn Sodium/therapeutic use , Proctitis/drug therapy , Adolescent , Adult , Aged , Biopsy , Cell Count , Chronic Disease , Clinical Trials as Topic , Cromolyn Sodium/administration & dosage , Eosinophils/cytology , Female , Humans , Male , Middle Aged , Proctitis/pathology , Rectum/pathologyABSTRACT
Side effects from carbenoxolone are common and are due to electrolyte disturbance, such as sodium retention and hypokalaemia. They occur particularly in the elderly, who may already be being treated for other illnesses. Eight patients are described with serious side effects from carbenoxolone therapy, some of which were unrecognized for some time because of inadequate follow-up or because clinicians were unfamiliar with them.
