Myo1e overexpression in lung adenocarcinoma is associated with increased risk of mortality.

This study aims to perform a comprehensive genomic analysis to assess the influence of overexpression of MYO1E in non-small cell lung carcinoma (NSCLC) and whether there are differences in survival and mortality risk in NSCLC patients depending on both DNA methylation and RNA expression of MYO1E. The DNA methylation probe cg13887966 was inversely correlated with MYO1E RNA expression in both LUAD and LUSC subpopulations showing that lower MYO1E RNA expression was associated with higher MYO1E DNA methylation. Late stages of lung cancer showed significantly lower MYO1E DNA methylation and significantly higher MYO1E RNA expression for LUAD but not for LUSC. Low DNA methylation as well as high RNA expression of MYO1E are associated with a shorter median survival time and an increased risk of mortality for LUAD, but not for LUSC. This study suggests that changes in MYO1E methylation and expression in LUAD patients may have an essential role in lung cancer's pathogenesis. It shows the utility of MYO1E DNA methylation and RNA expression in predicting survival for LUAD patients. Also, given the low normal expression of MYO1E in blood cells MYO1E DNA methylation has the potential to be used as circulating tumor marker in liquid biopsies.

Validation of an instrument for the evaluation of exchange transfusion (INEXTUS) via an OSCE.

INTRODUCTION: Exchange transfusion is the treatment of choice for patients with severe hyperbilirubinemia who do not respond to phototherapy. This procedure is highly complex and requires substantial expertise to perform, however it´s not done frequently enough to guarantee adequate training. Traditional learning scenarios do not have a space reserved for teaching this procedure or an instrument that fully and objectively evaluates the skills that a professional must acquire.  OBJECTIVES: The purpose was to construct and evaluate the INEXTUS instrument´s validity evidence relevant to internal structure, in a simulated scenario through the performance of an objective structured clinical exam (OSCE).  MATERIALS AND METHODS: The Delphi consensus methodology was utilized to design the instrument; six experts participated through three rounds using the Google Forms platform. The categories and items previously obtained were subjected to validation by nine experts through a dichotomous survey. Prior to data collection, the evaluators were trained through a pilot test with 10 medical students. Subsequently, all residents of a paediatric programme were evaluated through the OSCE methodology in a simulated scenario, with 6 stations, of a clinical case of a new-born with an explicit need for exchange transfusion. During their participation in the scenario, the residents were first evaluated with the instrument developed. Additionally, audio and video filming of all students who participated was performed with the aim of conducting a second evaluation two weeks after the first four evaluators participated. RESULTS: The final INEXTUS instrument consists of 46 subitems grouped into 23 items divided into 6 categories, demonstrating an inter-rater intraclass correlation coefficient of 0.96 (95% CI 0.94, 0.98 p-value < 0.001). For the Fleiss Kappa of the 23 items evaluated, concordance was evaluated for 14 items but could not be determined for the 9 remaining items because all the ratings were equal, either because the items were not performed or they were all performed adequately. Of the 14 items, 9 good scores were obtained (95% CI 0.61 to 0.8; p value < 0.001), and 5 very good scores were obtained (95% CI 0.81 to 1; p value < 0.001). CONCLUSIONS: The INEXTUS instrument evaluates exchange transfusion skills in medical personnel in training in simulated scenarios using the OSCE methodology; it has high validity and reliability and is a high-impact educational tool.

A Comparative Cross-Sectional Study of the Consequences of the COVID-19 Lockdown on Women's Health Behaviors in Spain.

Changes in health habits were observed during the COVID-19 pandemic. An unequal distribution of responsibilities may have generated unequal levels of stress in men and women, and, therefore, this may have led to different impacts on their health habits during lockdown. This study aimed to analyze the changes in eating habits, physical activity, sleep, and body weight in women, compared to men, because of lockdown. A comparative cross-sectional study was carried out. 2834 Spanish volunteers aged 19 to 76 completed an online survey on health habits. Descriptive and inferential analyses were performed using a cross-sectional methodology to explore gender differences. Results showed that men maintained their health habits to a greater extent, performing the same physical activity, while maintaining the quantity and quality of sleep, the quality of the diet, the quantity of the intake, and their mealtimes and body weight, whereas women's eating habits changed in relation to the quality of their diet and mealtimes, as their food intake and weight increased, and their sleep was poorer in quality and duration than it was before lockdown. This could be due to the higher levels of anxiety experienced by women as a result of working on essential jobs in addition to taking on more unpaid work associated with care and housework.

Predictors of Severe Intimate Partner Violence Among Antisocial and Family-Only Perpetrators: Victims' and Offenders' Characteristics.

The objective of this study was to determine the variables that predict severe intimate partner violence (S-IPV) according to the typology of abusers. The data were derived from 1,610 police reports on intimate partner violence (IPV) in Catalonia (Spain) between 2016 and 2017 obtained through the Police Risk Assessment Questionnaire. The study has compared a group of antisocial aggressors (n = 613) with a group of family-only perpetrators (n = 997). The chi-square test shows significant differences between antisocial and family-only groups for most of the variables analyzed. To determine the predictive variables of S-IPV in both groups, binary regression analyses were performed. In the antisocial group, death threats and degrading treatment by the aggressor significantly increased the probability of S-IPV, as did the victim's minimization or justification of the abuse, living together with the aggressor, isolation, and drug or alcohol abuse. In the family-only group, an increase in the severity of the abuse and death threats against partners significantly increased the likelihood of perpetrating S-IPV. For the victims, being abused by a previous partner and fear for her physical integrity were found to increase the probability of suffering S-IPV. On the other hand, having filed a prior complaint appears to protect women from S-IPV, but only when the victims have antisocial perpetrators. The findings show that S-IPV risk factors are common regardless of the sociocultural context. Modifying the weighting of the factors that make up the risk assessment tools according to the typology of the abuser is suggested, as well as improving knowledge of these factors to increase the accuracy of the estimated risk. Finally, adapting supervision and monitoring measures according to the type of aggressor and taking into consideration the woman's own perception of the danger she is in are also suggested.

The Relationship between Weight Status, Health-Related Quality of Life, and Life Satisfaction in a Sample of Spanish Adolescents.

Excess weight has been associated with numerous psychosocial problems and is considered to be one of the most important health problems of today. The aim of this study is to analyze the relationship between weight status, which is evaluated by means of the body mass index (BMI), and the health-related quality of life (HRQoL) and life satisfaction (LS) variables in Spanish adolescents, as well as to examine whether gender influences this interrelationship. A total of 1197 subjects studying in their 1st and 4th years of high school (mean age: 14.4 years, SD: 1.69) participated in the study by completing the Health Behavior in School-Aged Children (HBSC) questionnaire. Then, the participants were grouped into the following categories: underweight, normal weight, overweight, and obese. The results show that boys have significantly higher HRQoL as well as higher levels of LS. On the other hand, only the obese group shows significantly lower scores in both HRQoL and LS than those in the normal-weight group. The interaction of weight category and gender does not have a significant impact on the variables that have been analyzed (HRQoL or LS).

Retos de la implementación del aprendizaje basado en equipos en los programas de medicina / The challenges of implementing team-based learning to the medical major programs

Introducción: El aprendizaje basado en equipos es una estrategia de enseñanza y de aprendizaje centrada en el alumno, en la cual el profesor tiene un rol facilitador. Este constituye un método pedagógico de aprendizaje activo que mejora la motivación hacia el aprendizaje y lleva a los alumnos a aplicar sus conocimientos para resolver problemas y combinar la teoría con la práctica. Los avances en educación médica a nivel mundial han llevado a las escuelas de medicina a optar por este tipo de estrategias. Objetivo: Identificar los retos de la implementación del aprendizaje basado en equipos en los programas de medicina. Resultados: Mediante la aplicación del aprendizaje basado en equipos en los programas de medicina, se identificaron los factores de sobrecarga laboral y de estudio con incidencia en los participantes en la estrategia, la necesidad de garantizar entrenamiento previo a los actores del proceso, la importancia de la realización de una adecuada distribución de los grupos de trabajo, y los recursos adicionales que deben garantizarse. Conclusiones: Para obtener beneficios pedagógicos de forma plena, la implementación del aprendizaje basado en equipos debe ser sistemática, lo que requiere procesos de formación y preparación, tanto de los estudiantes como de los profesores. Como cualquier cambio, demandará convicción, tiempo y ajustes a lo largo del proceso(AU)

Introduction: Team-based learning is a student-centered teaching and learning strategy, in which the teacher has the role of a facilitator. It constitutes an active learning pedagogical method that improves motivation towards learning and leads students to apply their knowledge to solve problems and combine theory with practice. Advances in medical education worldwide have led medical schools to opt for such strategies. Objective: To identify the challenges of implementing team-based learning in the medical major programs. Results: Through the application of team-based learning to the medical major programs, such factors as work and study overloads were identified as having an impact on the strategy participants, together with the need to guarantee prior training to the process stakeholders, the importance of adequate distribution of the working groups, and the additional resources that must be guaranteed. Conclusions: In order to obtain full pedagogical benefits, the implementation of team-based learning must be systematic, a process requiring training and preparation processes for both students and teachers. Like any change, it will demand conviction, time and adjustments throughout the process(AU)

Evaluation of a ConvitVax/anti-PD-1 combined immunotherapy for breast cancer treatment.

Breast cancer therapies using checkpoints alone have not been highly effective. Based on previous experiences using the ConvitVax, an autologous tumor cells/bacillus Calmette-Guérin (BCG)/formalin-based vaccine, in breast cancer and the potential success of combined therapies, we sought to ascertain whether the ConvitVax combined with anti-PD-1 enhances the antitumor effect in a 4T1 breast cancer model. Animals received four weekly injections of either PBS (G1), ConvitVax (200 µg cell homogenate, 0.0625 mg BCG, 0.02% formalin) (G2), 50 µg anti-PD-1 (G3), or ConvitVax plus anti-PD-1 (200 µg cell homogenate, 0.0625 mg BCG, 0.02% formalin, 50 µg anti-PD-1) (G4). Five weeks post tumor induction all mice were euthanized, tumors extracted and evaluated pathologically and by immunohistochemistry. The combination group (G4) showed 10% more tumor necrosis, greater infiltration of PD-1+ cells and lower infiltration of TAMs, evidencing that the combination of ConvitVax and anti-PD-1 can improve the antitumor effect of the vaccine. Using a higher anti-PD-1 dose and administering each treatment at different times could further potentiate the effect of our therapy. Given the vaccine's low cost and simple preparation, its use in combination with checkpoints or other target-specific compounds may lead to a highly effective personalized breast cancer immunotherapy.

Two-dimensional semiconductors pave the way towards dopant-based quantum computing.

Since the proposal in 1998 to build a quantum computer using dopants in silicon as qubits, much progress has been made in the nanofabrication of semiconductors and the control of charge and spins in single dopants. However, an important problem remains unsolved, namely the control over exchange interactions and tunneling between two donors, which presents a peculiar oscillatory behavior as the dopants relative positions vary at the scale of the lattice parameter. Such behavior is due to the valley degeneracy in the conduction band of silicon, and does not occur when the conduction-band edge is at k = 0. We investigate the possibility of circumventing this problem by using two-dimensional (2D) materials as hosts. Dopants in 2D systems are more tightly bound and potentially easier to position and manipulate. Moreover, many of them present the conduction band minimum at k = 0, thus no exchange or tunnel coupling oscillations. Considering the properties of currently available 2D semiconductor materials, we access the feasibility of such a proposal in terms of quantum manipulability of isolated dopants (for single qubit operations) and dopant pairs (for two-qubit operations). Our results indicate that a wide variety of 2D materials may perform at least as well as, and possibly better, than the currently studied bulk host materials for donor qubits.

Autologous tumor cells/bacillus Calmette-Guérin/formalin-based novel breast cancer vaccine induces an immune antitumor response.

Autologous cancer cell vaccines represent a multivalent patient-specific treatment. Studies have demonstrated that these immunotherapies should be combined with immunomodulators to improve results. We tested in breast cancer the antitumor effects of a 200 µg autologous tumor cells homogenate combined with 0.0625 mg of bacillus Calmette-Guérin (BCG), and 0.02% formalin. We used a 4T1 murine model of BALB/c receiving four weekly injections of either this vaccine or control treatments. The control treatments were either Phosphate Buffer Saline, BCG treated with formalin, or the tumor cells homogenate plus BCG alone. We found that mice treated with the vaccine had the lowest tumor growth rate and mitosis percentage. The vaccinated group also showed a marked increase in infiltration of antitumor cells (natural killer, CD8 + T and CD4+ Th1 cells), as well as a decrease of myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs). Additionally, we also observed a possible activation of the immune memory response as indicated by plasma cell tumor infiltration. Our results demonstrate that our proposed breast cancer vaccine induces a potent antitumor effect in 4T1 tumor-bearing mice. Its effectiveness, low cost and simple preparation method, makes it a promising treatment candidate for personalized breast cancer immunotherapy.

Caracterización sobre la toma de decisiones éticas en las unidades de cuidado neonatal por parte de pediatras y neonatólogos / Characterization of making ethical decisions in neonatal care units by pediatricians and neonatologists / Caracterização em relação à deliberação ética nas unidades de cuidados neonatais por pediatras e neonatologistas

Introducción: Ha aumentado la sobrevida de los neonatos críticamente enfermos, lo que ha llevado a los profesionales encargados del cuidado de estos bebés a enfrentar frecuentemente decisiones éticas. En el presente trabajo se plantea el objetivo de caracterizar las situaciones éticas que enfrentan, el criterio que utilizan y la forma en que se toman las decisiones en los dilemas éticos por parte de los pediatras y neonatólogos. Métodos: Se realizó un estudio de corte transversal. Se invitaron a participar 87 neonatólogos y/o pediatras que quisieran contestar de forma voluntaria la encuesta para la caracterización y trabajaran en unidades neonatales de Chía y Bogotá entre el 1 de octubre de 2014 y 31 de enero de 2015, de los cuales aceptaron participar 45 profesionales (51.7%). Se realizó un análisis exploratorio de los datos, utilizando estadística descriptiva. Resultados: De los profesionales que contestaron la encuesta, el 100.0% se ha enfrentado a problemas éticos, el 60.0% han recibido algún tipo de capacitación en bioética, 33.0% se apoya en comités de ética, 98.0% tienen algún límite de viabilidad para iniciar reanimar y el 93.0% ha limitado el esfuerzo terapéutico; el 98.0% incluye a los padres en las decisiones y registra la decisión en la historia clínica. Conclusiones: Son frecuentes los conflictos éticos en la unidad neonatal. La mayoría cuenta con capacitación y comité de ética para la toma de decisiones. Entre los especialistas hay opiniones heterogéneas sobre ciertos problemas éticos en las unidades neonatales.

The survival of critically ill neonates has increased, which has led to professional caregivers of these babies to face ethical decisions about it. This paper outlines the aim of characterizing ethical situations that caregivers face, the criterion they use and how decisions on ethical dilemmas are taken by Pediatricians and Neonatologists. Methodology: A cross-sectional study was performed. 87 neonatologists and/or Pediatricians, who work in neonatal care units in Chia and Bogota between October 1 of 2014 and January 31 of 2015, were invited to participate and answer a characterization survey voluntarily, but only 45 professionals (51.7%) agreed to take part in it. An exploratory data analysis was performed by using descriptive statistics. Results: Professionals who answered the survey, 100.0% of them has faced ethical problems, 60.0% of them has received some training in bioethics, 33.0% relies on ethics committee, 98.0% has a viability limit to start reanimating and 93.0% has limited the therapeutic effort; 98.0% includes parents in decisions and registers the decision in the medical record. Conclusions: Ethical conflicts in the neonatal care unit are frequent. Most professionals have training and an ethics committee for decision-making. Among the specialists there are heterogeneous views on certain ethical problems in neonatal care units.

Introdução: O aumento da sobrevivência de recém-nascidos criticamente doentes, o que levou a cuidadores profissionais para esses bebês muitas vezes enfrentam decisões éticas. Objetivo: Neste trabalho é caracterizar as situações éticas e os critérios utilizados por pediatras e neonatologistas no jeito como tomam as decisões, frente aos dilemas éticos surgidos. Métodos: O estudo realizado foi de tipo transversal. De 87 neonatologistas e / ou pediatras convidados a participar no estudo realizado entre 01 de outubro de 2014 e 31 de janeiro de 2015, 45 profissionais (51,7%), que trabalham nas unidades neonatais de Chia e Bogotá (Colȏmbia), aceitaram livremente responder as perguntas. Os dados foram estudados por meio de estatística descritiva. Resultados: As respostas da pesquisa mostraram que 100,0% dos professionais tem enfrentado problemas éticos, 60,0% receberam alguma preparação em bioética, 33,0% se apoia na comissão de ética, 98,0% têm um limite de viabilidade para começar a reanimação e 93,0% tem limitado o esforço terapêutico; 98,0% inclui os pais nas decisões e o registra no prontuário. Conclusões: Os conflitos éticos são frequentes na unidade neonatal. A maioria tem formação e conta com a comissão de ética para tomar as decisões. Entre os especialistas há pontos de vista heterogêneos sobre certos problemas éticos nas unidades neonatais.

Pelagra / Pellagra

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Signatures of a two-dimensional ferromagnetic electron gas at the La0.7Sr0.3MnO3/SrTiO3 interface arising from orbital reconstruction.

The magnetoresistance of La0.7Sr0.3MnO3/SrTiO3 superlattices with magnetic field rotating out-of-plane shows unexpected peaks for in-plane fields. Resistivity calculations with spin-orbit coupling reveal that orbital reconstruction at the manganite interface leads to a 2D ferromagnetic electron gas coupled antiparallel to the manganite "bulk". These orbital and magnetic reconstructions are supported by X-ray linear dichroism and ab initio calculations.

Estudio sobre la Red Nomológica de la Envidia en Población Infanto-juvenil / A Study on the Envy Nomological Network in Children and Adolescents

La envidia es una parte esencial de la condición humana que posibilita el correcto desarrollo del niño. El presente trabajo explora la red nomológica de la envidia en relación con la sintomatología depresiva, la ansiedad y la ira. La muestra estuvo constituida por 210 sujetos (43.8% varones) con edades comprendidas entre 10 y 14 años. Los centros educativos y las aulas fueron seleccionados al azar. En este estudio ex post facto se llevaron a cabo correlaciones de Pearson entre las medidas evaluadas, así como comparaciones de medias entre sujetos que presentaban envidia o no; por otro lado, se realizó un análisis factorial exploratorio para examinar la red nomológica de la envidia, y un análisis de regresión múltiple para conocer la relación entre ésta y el resto de emociones evaluadas. Los resultados mostraron que el entramado de relaciones entre la envidia y otras emociones está condicionado por la edad y el sexo de los sujetos. La envidia mostró una clara relación con la ira, especialmente con su vertiente rasgo, y fue esta emoción la que en mayor medida predijo cada una de sus dimensiones. La dimensión de la envidia, deseo por lo ajeno, se asoció con un mayor desajuste emocional. A pesar de la interconexión de la envidia con las restantes emociones, ésta emerge como una emoción independiente y diferenciada de las restantes. La escasez de trabajos sobre este tema en población infantil sugiere la necesidad de un mayor número de estudios.

Envy is an essential ingredient of human nature, which facilitates a proper development of children. This study analyzes the envy nomological network in relation to depression, anxiety and anger. 210 subjects aged 10 to 14 (43.8% males) took part in the study. The schools were randomly selected from a database and so were the classrooms. Different Pearson's correlations and comparisons of means between envious and nonenvious subjects were carried out in this ex post facto study. Moreover, an exploratory factor analysis and a multiple regression analysis were used to examine the envy nomological network and to check the relationship between envy and several emotions assessed. Results have shown that the envy nomological network depends on both, children's age and sex. Envy was mainly related to trait anger, which predicts every envy dimension. The dimension called "Wish for other's belongings" was the one related with a higher number of emotional disorders. Despite the link between envy and the other emotions, it constitutes an independent construct, different from the others. More studies are needed given the lack of works on this topic.

Experiencia de trabajo grupal con padres de niños con síndrome de déficit atencional / Experience of therapy group to parents of children with attention deficit disorder

El Programa de Trastornos del Desarrollo del Centro de Salud Mental San Joaquín, de la Universidad Católica en respuesta a las necesidades del grupo consultante y debido a la alta demanda de atención de niños diagnosticados con SDA, decidió diseñar e implementar una intervención para padres, de forma complementaria y paralela al taller en el que participaban sus hijos. Los objetivos de la intervención parental fueron psicoeducar respecto a la comprensión del trastorno y desarrollar estrategias de manejo, y a su vez, favorecer la adherencia y el compromiso con el tratamiento de sus hijos. Esta experiencia se realizó los años 2007 y 2008, mediante seis sesiones teórico-prácticas, las que revelaron escasa delimitación entre el sistema parental y el filial, dificultad en el desarrollo de la autonomía, inquietudes respecto del rol de padres y sentimiento de exclusión respecto del tratamiento de su hijo. A partir de esta intervención se evidenció una disminución en la sensación de exclusión de los padres, además permitió una mejor elaboración del diagnóstico y optimizó el tiempo de atención respecto de las consultas individuales.

The Developmental Disorders Program mental health center San Joaquin, of the Catholic University of Chile, due to its high demand of attention for patiens with DDA, decided to design and implement a workshop for parents with children with Deficit Disorder Attention (DDA), as a complement estrategy of intervention to the workshop in wich their children participate.The objectives of the parental intervention were educated in psychological subjets, regarding the understanding of their children´s disorder and the development of management strategies, and in turn, promote adherence and commitment to the treatment of their children. This experiment was conducted in the years 2007 and 2008, through six theoretical and practical sessions, which revealed little distinction between the parental and the filial system, difficulties in the development of autonomy, concerns about the parenting role and feelings of exclusion from the treatment of their son. This intervention promoted a decrease in the sense of exclusion of parents also enabled better diagnosis and development of optimized on-call time for individual consultations.

Cumplimiento terapéutico y calidad de vida en pacientes crónicos / Therapeutic compliance and quality of life in chronic patients

Objetivo. Conocer el cumplimiento terapéutico y percepción de salud en dos Centros de Salud, en los que se utilizó un documento normalizado de tratamiento. Diseño. Ensayo clínico. Emplazamiento. Zonas de Salud de Sillería y Ocaña (Toledo). Participantes. Pacientes, de edad ≥ 18 años, en cartera de servicios que siguen tratamiento para la hipertensión, dislipemia y Diabetes Mellitus. Se realizó un muestreo aleatorio simple de los listados de estos pacientes. Mediciones principales. En los dos grupos se entregó un documento sobre medidas higiénico-dietéticas y consejos de cumplimentación farmacológica. En el grupo de intervención además del documento anterior se entregó una hoja de tratamientos crónicos. Se realizaron cuatro visitas bimensuales en un periodo de seguimiento de ocho meses. Para el estudio del cumplimento terapéutico se utilizó el recuento de comprimidos. En la primera y última visita se pasó la versión española del EuroQol-5D. Resultados. Se incluyeron en el estudio 309 pacientes con una edad media de 69,2 ± 10,7 años (55,3% eran mujeres). Un total de 156 pacientes fueron aleatorizados al grupo de intervención y 153 al grupo control. En la última visita 173 pacientes cumplieron adecuadamente el tratamiento (63,1%; IC 95%: 57,4 - 68,8), frente a 152 en la visita basal del estudio (55,5%; IC 95%: 49,6 - 61,4), Chi-cuadrado = 96,7 y p < 0,0001. Al analizar el número de pacientes cumplidores por grupo de estudio, en la visita fi nal, no se encontraron diferencias signifi cativas entre ambos grupos. Los grupos del estudio no mostraron diferencias en la percepción de su propia salud. Conclusiones. El documento normalizado de tratamiento no aportó una mejora en el cumplimiento terapéutico del grupo de intervención. La intervención realizada en ambos grupos y el seguimiento mejoró el cumplimiento terapéutico en ambos grupos (AU)

Objective. To determine treatment compliance and health perception at two Primary Health Centres, in which a standardized treatment protocol was used. Design. Clinical trial. Setting. Primary Health Centres at Sillería and Ocaña (Toledo). Subjects. Patients aged ≥ 18 years, in the portfolio services being treated for hypertension, dyslipidaemia and diabetes. A simple random sampling from the lists of these patients was made. Main measurement. Patients in both groups were given a sheet setting out health-dietary measures and advice on treatment compliance. The intervention group were also given a sheet of chronic treatments.. There were four two-monthly visits over a follow-up period of eight months. Pill count was used to determine treatment compliance. At the fi rst and last visit the Spanish version of the EuroQol- 5D was performed. Results. A total of 309 patients with an average age of 69.2 ± 10.7 years were included in the study (55.3% were women). Of these patients, 156 patients were randomised to the intervention group and 153 to the control group. At the final visit, 173 patients had good treatment compliance (63.1%; CI 95%, 57.4 - 68.8), as opposed to 152 at the baseline visit (55.5%; CI 95%, 49.6 - 61.4), Chi-square = 96.7 and p < 0,0001. At the final visit, no significant differences were found between the two groups as regards treatment compliance. There were no differences in health perception between the two study groups. Conclusions. The standardized treatment document did not contribute to an improvement in treatment compliance in the intervention group. Interventionand follow-up improved treatment compliance in both groups (AU)

Anemia y neuropatía periférica secundarias a linezolid / Anemia and peripheral neuropathy associated with linezolid

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