Inventory of red algae (Rhodophyta) from the Sian Ka'an Biosphere Reserve, Mexican Caribbean / Inventário de algas vermelhas da Reserva da Biosfera Sian Ka'an, Caribe Mexicano

Abstract Studies of marine and estuarine red algae (Rhodophyta) are in the early stages in the littoral of the Sian Ka'an Biosphere Reserve, Mexico. The inventory of these organisms was made based on samples obtained from ten sampling during 2009 to 2015 in 22 localities, eight of them in marine and fourteen in estuarine environments. We found 182 species and subspecific taxa of Rhodophyta. The Rhodomelaceae family was the best represented with 65 taxa, followed by Ceramiaceae 13 and Delesseriaceae 12. Of the 182 taxa, 25 are new records Sian Ka'an Biosphere Reserve with Harveylithon rupestre, Spongites fruticulosus, Acrochaetium barbadense, Dasya harveyi, Chondria pumila, Spermothamnion repens, Metapeyssonnelia milleporoides and M. tangerina being new records for the Mexican Caribbean. Of the 182 species, 119 of them are epiphytes, most of them, 54, grew exclusively on other macroalgae, 29 on mangrove roots and 8 on Thalassia leaves. The floristic list is accompanied by data on seasonality, reproduction, habitat, and environment. Species diversity was compared between the winter rains, dry and rainy seasons during the period study. The Rhodophyta of the Sian Ka'an Biosphere Reserve is tropical, and the greatest diversity was found in the marine environment with 83 taxa and during the winter rains with 132.

Resumo: Os estudos de algas vermelhas marinhas e estuarinas (Rhodophyta) estão em fase inicial no litoral da Reserva da Biosfera de Sian Ka'na, México. O inventário desses organismos foi feito com base em amostras obtidas em oito amostragens no período do 2009 a 2015 em 22 localidades, sendo oito em ambientes marinhos e quatorze em ambientes estuarinos. Neste levantamento, foram identificadas um total de 182 espécies e táxons subespecíficos de Rhodophyta. A família Rhodomelaceae foi a mais representativa com 65 táxons, seguida por Ceramiaceae com 13 e Delesseriaceae com 12. Dos 182 táxons, 25 são referidos pela primeira vez para a Reserva da Biosfera Sian Ka'an, sendo Harveylithon rupestre, Spongites fruticulosus, Acrochaetium barbadense, Dasya harveyi, Chondria pumila, Spermothamnion repens, Metapeyssonnelia milleporoides e M. tangerina também novos registros para o Caribe mexicano. Das 182 espécies, 119 são epífitas, sendo a maioria, 54, aderidas exclusivamente em outras macroalgas, 29 em raízes de mangue e 8 em folhas de Thalassia. A lista florística apresentada é acompanhada de dados sobre sazonalidade, reprodução, habitat e ambiente. A diversidade de espécies foi comparada entre as temporadas de chuvas de inverno, seca e chuvas de verão durante o período estudado. Rhodophyta da Reserva da Biosfera Sian Ka'an săo tropicais, e a diversidade mais representativa foi encontrada no ambiente marinho com 83 táxons e durante as chuvas de inverno com um total de 132 táxons.

Analysis of prognostic factors of failure in perineal urethrostomy.

PURPOSE: To identify prognostic factors of failure in patients undergoing perineal urethrostomy (PU) with Blandy technique, with inverted U-shaped perineal flap. METHODS: This is a retrospective study of PU of non-oncological causes (2001-2017). Data of age, BMI, history of diabetes mellitus, etiology of urethral stricture, type of stricture, previous surgeries, dilatation and suprapubic catheter were collected. Failure was defined as the need for any instrumentation after surgery. Variables were analyzed by Cox regression and Kaplan-Meier curves were used for survival analysis. RESULTS: A total of 115 PU were performed. Median age was 61 years (IQR 53-68) and BMI 27.9 (IQR 25-30.9). The most frequent etiologies were: lichen sclerosus (30.4%), iatrogenic (27%), and idiopathic (25.7%). 62.6% had panurethral stricture. There were no complications in 73%. Clavien I complications occurred in 25.2%, Clavien II in 0.9% and Clavien IVa in 0.9%. The overall success rate was 51.3% with a median follow-up of 71 months. In the last 8 years, it was 75%. In the multivariate analysis, we found that age (p = 0.01), BMI (p = 0.01), date of surgery (p = 0.01), and suprapubic catheter (p = 0.003) were predictive variables. The voiding satisfaction rate was 88.7%. CONCLUSIONS: PU with Blandy technique is a surgery with low morbidity. During the entire study period, it had a failure rate of 48.7% but the failure rate decreased to 25% over the last 8 years. Age, BMI, date of surgery and suprapubic catheter are the most important prognostic factor of failure.

DNA Methylation Urine Biomarkers Test in the Diagnosis of Upper Tract Urothelial Carcinoma: Results from a Single-Center Prospective Clinical Trial.

PURPOSE: The correct risk categorization and staging of upper tract urothelial cancer (UTUC) is key for disease management. Computerized tomography urography and urinary cytology have limited accuracy for risk stratification of UTUC. Ureteroscopy may increase the risk of bladder cancer recurrence. Recently, Bladder EpiCheckTM (EpiCheck) showed a high accuracy in the detection of bladder cancer. The aim of the study is to investigate the diagnostic accuracy of EpiCheck in the clinical management of UTUC and to compare it with urinary cytology. MATERIALS AND METHODS: In this single-arm, blinded, prospective, single-center study (February 2019-December 2020), all patients who were candidates for ureteroscopy for suspicion of UTUC were included. Bladder and upper urinary tract (UUT) samples were collected before ureteroscopy to test for cytology and Epicheck. EpiCheck accuracy was calculated in bladder and UUT samples and compared to cytology. RESULTS: EpiCheck resulted diagnostic in 83/86 (97%) and 73/75 (97%) of UUT and bladder samples. Histology was positive in 47/83 (57%) and 42/73 (58%) cases, respectively. In UUT samples, EpiCheck yielded a sensitivity/specificity/ negative predictive value (NPV)/positive predictive value of 83%/79%/77%/84% vs 59%/88%/61%/87% of cytology. The sensitivity/NPV for high-grade tumors was 96%/97% for EpiCheck vs 71%/86% for cytology. EpiCheck indicated ureteroscopy in 45/80 (56%) patients, missing 17%/4% of all/high-grade UTUC with 9% of unnecessary ureteroscopy. In bladder samples, the sensitivity/NPV for high-grade tumors was 71%/88% for EpiCheck and 59%/87% for cytology. CONCLUSIONS: Epicheck may be an important tool to decrease the number of unnecessary ureteroscopy. The clinical implementation of EpiCheck in UTUC warrants further investigation in multicentric prospective randomized trials.

Contemporary outcomes of bladder carcinoma in situ treated with an adequate bacille Calmette-Guérin immunotherapy.

OBJECTIVE: To assess whether bacillus Calmette-Guérin (BCG) responsiveness after initiation of an adequate BCG treatment (at least five of six instillations of induction and at least two of three instillations of maintenance) impacts oncological outcomes in patients with carcinoma in situ (CIS) of the bladder treated with BCG immunotherapy. PATIENTS AND METHODS: Data were available for 193 patients with bladder CIS with or without associated cTa/cT1 disease who received an adequate BCG treatment between 2008 and 2015. Bladder biopsies were taken at 6 months and patients were then stratified as either BCG responsive (negative biopsies) or BCG unresponsive (positive biopsies). Inverse probability weighting (IPW)-adjusted Kaplan-Meier and IPW-adjusted Cox regression were performed to compare progression-free survival (PFS), radical cystectomy-free survival (RCFS), overall survival OS, and cancer-specific survival (CSS) in the two groups. RESULTS AND LIMITATIONS: Comparing the BCG-responsive and BCG-unresponsive groups, IPW-adjusted Kaplan-Meier analysis revealed, respectively, a median (interquartile range) of PFS of 9 (5-15) vs 48.5 (28-77) months (P = 0.001), a RCFS of 11 (9-15) vs 49 (24-76) months (P < 0.001), and a CSS of 25 (13-60) vs 109 (78-307) months (P = 0.004). On IPW-adjusted Cox regression analysis, BCG-unresponsive patients had a worse PFS (hazard ratio [HR] 3.40, 95% confidence interval [CI] 1.59-7.27), RCFS (HR 3.52, 95% CI 1.77-7), and CSS (HR 4.42, 95% CI 1.95-10.01). We found no significant differences for OS. CONCLUSION: Using an IPW method we found that lack of response after initiation of an adequate BCG treatment has prognostic implications beyond identification of complete response in patients with CIS. BCG-unresponsive patients, satisfying the novel definition of BCG unresponsive, showed a poor PFS, RCFS, and CSS. In this setting, the patients should be counselled regarding RC as a first option or enrolled in a clinical trial if they refuse RC or are unfit for surgery.

Impact of clinical and pathological subtypes of carcinoma in situ (CIS) of the bladder: Lessons learned from long-term follow-up of a series of CIS patients treated with BCG.

OBJECTIVE: Some attempts have previously been made to stratify patients with CIS for the purpose of risk-adapted clinical management and clinical trial design. In particular, two classification systems have been proposed: clinical classification, comprising primary (P-CIS), concomitant (C-CIS), and secondary (S-CIS) disease, and pathological classification, comprising P-CIS, cTa-CIS, and cT1-CIS. The aim of the present study was to assess the impact of both classifications on BCG response, recurrence-free survival (RFS), progression-free survival (PFS), overall survival (OS), and cancer-specific survival (CSS). PATIENTS AND METHODS: We performed a retrospective analysis of 386 patients with bladder CIS, with or without associated cTa/cT1 disease, treated with BCG instillations between 2008 and 2015. Patients were stratified according to the two classification systems. Cox multivariate regression models were used to assess the impact of these subtypes on BCG response, RFS, PFS, OS, and CSS. We also performed a cumulative meta-analysis according to PRISMA guidelines. RESULTS: The median follow-up was 70.5 months. According to the clinical classification, 34 (8.8%) patients had P-CIS, 81 (21%) S-CIS, and 271 (70.2%) C-CIS. The pathological classification showed 34 (8.8%) patients to have P-CIS, 190 (49.2%) cTa-CIS, and 162 (42%) cT1-CIS. In the overall cohort, BCG response was reported in 296 (76.7%); 159 (41.2%) had recurrence, 55 (14.2%) had progression, and 67 (17.4%) underwent radical cystectomy. Death from any cause was recorded in 135 (35%) and death from urothelial carcinoma in 38 (9.9%). Cox multivariate regression analysis showed that neither clinical classification nor pathological classification is an independent predictive factor for BCG response, RFS, PFS, OS, or CSS after adjusting for confounders. In the pooled meta-analysis, two studies and the present series were included for evidence synthesis, recruiting a total of 941 patients. We found no statistically significant difference across the groups for both classifications with respect to BCG response, RFS, PFS, and CSS. CONCLUSIONS: Currently, the supporting evidence for an impact of clinical classification and pathological classification on oncological outcomes of CIS of the bladder is insufficient to justify their use to guide clinical management or follow-up.

Diagnostic accuracy of ureteroscopic biopsy in predicting stage and grade at final pathology in upper tract urothelial carcinoma: Systematic review and meta-analysis.

OBJECTIVE: To assess the accuracy of ureteroscopic (URS) biopsies in predicting stage and grade at final pathology in upper tract urothelial carcinoma (UTUC). MATERIALS AND METHODS: The meta-analysis was performed in accordance with the PRISMA statement. Studies providing data on tumor stage and grade at URS biopsy and surgical specimens were included. The negative predictive value (NPV) implies concordance between the absence of subepithelial connective tissue invasion or the presence of low-grade tumors at URS biopsy and the absence of a muscle-invasive disease in the final pathology. RESULTS: A total of 23 studies were included (3547 patients). The stage-to-stage match between URS biopsy/final pathology showed a positive predictive value (PPV) for cT1+/muscle-invasive disease of 94% (95% CI: 84%-100%) and a NPV for cTa-Tis/non-muscle-invasive disease of 60% (95% CI: 52%-68%). The grade-to-grade match between URS biopsy/final pathology was 66% (95% CI: 55%-77%) for low-grade (cLG/pLG) tumors and 97% (95% CI: 94%-98%) for high-grade (cHG/pHG) tumors. The PPV for cHG/muscle-invasive disease was 60% (95% CI: 54%-66%) and the NPV for cLG/non-muscle-invasive disease was 77% (95% CI: 73%-82%). The undergrading and understaging rates were 32% (95%CI: 25%-38%) and 46% (95% CI: 38%-54%), respectively. CONCLUSIONS: There is a substantial correlation between tumor grade at URS biopsy and the final pathology. The identification of cHG tumors and subepithelial connective tissue invasion (cT1+) in URS biopsy showed a moderate and a strong correlation with invasive UTUC, respectively. Nevertheless, a certain risk of undergrading and understaging should be assumed.

Laparoscopic Management of Chylous Leakage Using a Direct Lymph Node Injection with Methylene Blue as a Leakage Point Location Strategy in a Patient with Retroperitoneal Extragonadal Seminoma.

Background: The first-line treatment in cases of chylous leakage is conservative, and operation should be considered only in patients who fail to respond to this treatment. The main clinical concern is the difficulty of intraoperative localization of the site of leakage that can affect surgical outcome. Case Presentation: A 33-year-old man presented with a 4-month history of abdominal pain and weight loss. CT scan revealed enlarged retroperitoneal lymph nodes. Retroperitoneal lymph node biopsy was performed owing to the suspicion of lymphoproliferative disease, with a pathological result of nonspecific adenitis. Because of persistence of pain, an abdominal CT scan showed a large left retroperitoneal fluid collection that was found to be compatible with chyle after drainage. Conservative treatment was established, but because of its failure, surgical management was attempted by the laparoscopic approach. Intraoperative direct lymph node injection of methylene blue was used as a leakage point location strategy that allows selective ligation of the site of leakage. Thereafter a gradual reduction in chyle output to zero was observed. Conclusion: The laparoscopic approach could be a feasible and successful method for the management of chyle leakage in patients refractory to conservative treatment. Intraoperative direct lymph node injection of methylene blue could be a useful technique to facilitate detection of the site of leakage during operation.

Mortalidad y factores asociados en pacientes con síndrome de dificultad respiratoria agudo (SDRA) en un hospital universitario / Mortality and associated factors in patients with acute respiratory distress syndrome (ARDS) in a university hospital

Introducción: el síndrome de dificultad respiratorio agudo (SDRA) es la manifestación más grave de compromiso pulmonar agudo. Actualmente no hay datos disponibles para documentar los factores asociados con la mortalidad en nuestro medio. Diseño del estudio: estudio de cohorte retrospectiva. Objetivo: describir los factores asociados a la mortalidad en pacientes adultos hospitalizados en la unidad de cuidado crítico con SDRA entre enero 2007 y diciembre de 2011. Métodos: se recolectaron datos con respecto a causas de SDRA, estancia hospitalaria y en la UCI, gravedad de la enfermedad crítica y el estado vital al egreso. Se realizó un análisis de regresión logística para determinar los factores asociados de manera independiente con la mortalidad hospitalaria. Resultados: se analizaron 141 pacientes con SDRA, la mediana de edad fue 44 años y 62.9% fueron hombres. La primera causa de SDRA fue el choque séptico de origen pulmonar en 49.6% y el APACHE II tuvo una mediana de 18. La mediana de la PaO2/FIO2 al inicio del SDRA fue 91.5 y a las 72 horas fue 125. La mediana de PEEP requerido al inicio de la ventilación mecánica fue de 10 cmH2O y a las 72 horas fue de 12. La estancia en la UCI fue de 13 días y la mortalidad hospitalaria fue del 54%. Los factores asociados con mortalidad fueron el choque de origen pulmonar (OR = 2.45; IC 95% = 1.04-5.77) y el puntaje APACHE II (OR = 1.05 por cada punto; IC 95% = 1.003-1.1). El nivel de PEEP igual o menor en las primeras 72 horas se comportó como un factor protector (OR = 0.36; IC 95% = 0.16-0.82). Conclusiones: el SDRA tiene una alta mortalidad en nuestro medio y los factores más fuertemente asociados con dicha mortalidad son dependientes de la enfermedad de base y de la intensidad de la respuesta biológica a la misma. (Acta Med Colomb 2015; 40 305-309).

Introduction: acute respiratory distress syndrome (ARDS) is the most serious manifestation of acute pulmonary compromise. Currently no data are available to document the factors associated with mortality in our environment. Study Design: retrospective cohort study. Objective: To describe the factors associated with mortality in adult patients hospitalized in critical care unit with ARDS from January 2007 to December 2011. Methods: Data were collected with regard to causes of ARDS, hospital and ICU stay, critical illness severity and vital status at discharge. Logistic regression analysis was performed to determine factors independently associated with hospital mortality. Results: 141 patients with ARDS were analyzed; the median age was 44 years and 62.9% were men. The first cause of ARDS was septic shock of pulmonary origin in 49.6% and APACHE II had a median of 18. The median PaO2/FIO2 at the beginning of ARDS was 91.5 and at 72 hours was 125. The median PEEP required at the initiation of mechanical ventilation was 10 cmH2O and at 72 hours 12. The ICU stay was 13 days and hospital mortality was 54%. Factors associated with mortality were the shock of pulmonary origin (OR = 2.45; 95% CI = 1.04-5.77) and APACHE II (OR = 1.05 per point, 95% CI = 1.003-1.1). PEEP level equal to or less within 72 hours acted as a protective factor (OR = 0.36; 95% CI = 0.16-0.82). Conclusions: ARDS has a high mortality in our environment and the factors most strongly associated with this mortality are dependent on the underlying disease and the intensity of biological response to it. (Acta Med Colomb 2015; 40 305-309).

Características clínicas y demográficas de pacientes con trauma raquimedular Experiencia de seis años / Clinical and demographic characteristics of patients with spinal cord injury Six years experience

Introducción: el trauma raquimedular (TRM) es una entidad potencialmente catastrófica y la información acerca de las características del TRM penetrante relacionadas con violencia, particularmente las heridas por arma de fuego es escasa. Diseño del estudio: estudio de cohorte retrospectiva. Objetivos: determinar las características clínicas y demográficas de la población con TRM atendidas en un hospital de tercer nivel de Medellín. Métodos: revisamos las historias clínicas de los pacientes admitidos con diagnóstico de TRM entre enero de 2005 y diciembre de 2010. Se recolectaron datos con respecto a estancia hospitalaria y en la unidad de cuidados intensivos (UCI), el estado vital y la recuperación neurológica al egreso. Resultados: tuvimos 68 casos de TRM con una frecuencia de 12 casos por 1000 pacientes admitidos a la UCI. La edad media fue de 28 años y 91% fueron del sexo masculino. La principal causa de TRM fue herida por arma de fuego (57%) seguido por accidentes de tránsito (32%). La estancia media de UCI fueron seis días, 56% de los pacientes requirió ventilación mecánica y 37% requirió traqueostomía. El nivel de lesión medular más frecuente fue cervical. La mortalidad hospitalaria fue de 21%, todos estaban con ventilación mecánica y entre más alto fue el nivel de lesión medular mayor era la mortalidad. Conclusiones: nuestra investigación muestra que la población principalmente afectada por el TRM en nuestro medio son los jóvenes y la mortalidad, así como la estancia, complicaciones infecciosas y discapacidad tienen relación directa con el nivel de lesión medular. (Acta Med Colomb2014; 40: 45-50).

Introduction: spinal cord injury (SCI) is a potentially catastrophic entity and information about the characteristics of pervasive SCI related to violence, particularly gunshot wounds, is scarce. Study Design: Retrospective cohort study. Objectives: to determine the clinical and demographic characteristics of the population with SCI attended in a tertiary hospital in Medellin. Methods: The medical records of patients admitted with a diagnosis of SCI between January 2005 and December 2010 were reviewed. Data regarding stay in the hospital and intensive care unit (ICU), vital status and neurological recovery at hospital discharge were collected. Results: there were 68 cases of SCI at a rate of 12 cases per 1000 patients admitted to the ICU. The average age was 28 years and 91% were male. The main cause of SCI was gunshot wounds (57%) followed by traffic accidents (32%). The mean ICU stay was six days, 56% of patients required mechanical ventilation and 37% required tracheostomy. The most common level of spinal cord injury was cervical. Hospital mortality was 21%, all were mechanically ventilated and the higher the level of spinal cord injury, the greater was the mortality. Conclusions: our research shows that people mainly affected by the SCI in our environment are young and mortality, as well as stay, infectious complications and disability are directly related to the level of spinal cord injury. (Acta Med Colomb 2014; 40: 45-50).

Cloning, expression and bioinformatics analysis of ATP sulfurylase from Acidithiobacillus ferrooxidans ATCC 23270 in Escherichia coli.

Molecular studies of enzymes involved in sulfite oxidation in Acidithiobacillus ferrooxidans have not yet been developed, especially in the ATP sulfurylase (ATPS) of these acidophilus tiobacilli that have importance in biomining. This enzyme synthesizes ATP and sulfate from adenosine phosphosulfate (APS) and pyrophosphate (PPi), final stage of the sulfite oxidation by these organisms in order to obtain energy. The atpS gene (1674 bp) encoding the ATPS from Acidithiobacillus ferrooxidans ATCC 23270 was amplified using PCR, cloned in the pET101-TOPO plasmid, sequenced and expressed in Escherichia coli obtaining a 63.5 kDa ATPS recombinant protein according to SDS-PAGE analysis. The bioinformatics and phylogenetic analyses determined that the ATPS from A. ferrooxidans presents ATP sulfurylase (ATS) and APS kinase (ASK) domains similar to ATPS of Aquifex aeolicus, probably of a more ancestral origin. Enzyme activity towards ATP formation was determined by quantification of ATP formed from E. coli cell extracts, using a bioluminescence assay based on light emission by the luciferase enzyme. Our results demonstrate that the recombinant ATP sulfurylase from A. ferrooxidans presents an enzymatic activity for the formation of ATP and sulfate, and possibly is a bifunctional enzyme due to its high homology to the ASK domain from A. aeolicus and true kinases.

Uso de células madre en el complejo bucofacial / Use of stem cells in the orofacial complex

Introducción: las células madre tienen la capacidad de dividirse indefinidamente y diferenciarse en distintos tipos de células especializadas, no solo desde el punto de vista morfológico sino también de forma funcional. Los conocimientos que en este campo de la medicina se realizan, han elevado las expectativas de enfermos y profesionales de la salud que contribuyen a la curación de múltiples enfermedades. Desarrollo: se realizó una revisión bibliográfica acerca del uso de las células madre en el complejo bucofacial, las cuales pueden clasificarse en embrionarias y adultas según su estado evolutivo, y en relación con su potencialidad celular en totipotentes, pluripotentes y multipotentes, que actúan en la regeneración del tejido óseo, el ligamento periodontal, la dentina y el diente. Conclusiones: se demostró que las células madre juegan un importante papel en la regeneración de diferentes estructuras del complejo bucofacial y tienen su mecanismo de acción a nivel del complejo pulpo-dentinal, el ligamento periodontal, y en la regeneración de deficiencias esqueléticas cráneo-faciales.

Introduction: stem cells have the capacity of dividing themselves into various types of specialized cells, not only from the morphological point of view but functionally as well. Scientific advances in the field of regenerative medicine have increased life expectancy of sick people and also better results of dental professionals. These advances do contribute to cure various diseases. Discussion: a bibliographical review on the use of stem cells in the orofacial complex was carried out. These cells are classified according to their evolution state into embryonic and adult, and according to their cellular potentiality into totipotent, pluripotent and multipotent. They regenerate bone tissue, periodontal ligament, dentine and tooth. Conclusion: it has been demonstrated that stem cells play an important role in the regeneration of different structure of the orofacial complex. They have their mechanism of action in the pulp-dentinal complex, periodontal ligament and in the regeneration of craniofacial skeletal defects.

Acción analgésica de la digitopuntura previa al tratamiento estomatológico convencional en las pulpitis agudas / Analgesic action of digitopuncture previous to the conventional stomatological treatment in acute pulpitis

Los pacientes con pulpitis aguda, producto al dolor que las caracteriza, en ocasiones no permiten realizar un tratamiento endodóntico de urgencia satisfactorio. Objetivo: evaluar la acción analgésica de la digitopuntura previo al tratamiento estomatológico convencional en las pulpitis agudas. Método: se realizó un estudio de evaluación, cuasi-experimental de tipo antes y después, en la consulta de urgencias estomatológica del policlínico Previsora desde septiembre de 2008 hasta abril de 2009, el universo de estudio se conformó por los pacientes que acudieron a la consulta con dolor producido por pulpitis aguda, la muestra quedó se integró por 40 pacientes que no habían recibido tratamiento previo. Se evaluó la intensidad del dolor a los 30min y se valoró la cooperación del paciente durante el tratamiento convencional. Resultados: en el 90 por ciento de los casos se evaluó como eficaz el tratamiento realizado y los pacientes refirieron sentirse satisfechos (AU)

Patients with acute pulpitis caused to the pain that characterizes it, in occasions allow carrying out a satisfactory endodontic treatment of urgency. Objective: to evaluate the analgesic action of digitopuncture previous to the conventional stomatological treatment in acute pulpitis. Method: a before and after type quasi-experimental, evaluation study was performed, in the stomatological urgency consultation at Previsora polyclinic from September 2008 to April 2009, the study universe was conformed by patients that came to the consultation with pain caused by acute pulpitis and the sample was integrated by 40 patients who had not received previous treatment. The intensity of pain was evaluated to 30 minutes and patient's cooperation was valued during the conventional treatment. Results: in 90 percent of cases was evaluated as effective the treatment carried out and patients referred to feel satisfied with the treatment received (90 percent) (AU)

Acción analgésica de la digitopuntura previa al tratamiento estomatológico convencional en las pulpitis agudas / Analgesic action of digitopuncture previous to the conventional stomatological treatment in acute pulpitis

Los pacientes con pulpitis aguda, producto al dolor que las caracteriza, en ocasiones no permiten realizar un tratamiento endodóntico de urgencia satisfactorio. Objetivo: evaluar la acción analgésica de la digitopuntura previo al tratamiento estomatológico convencional en las pulpitis agudas. Método: se realizó un estudio de evaluación, cuasi-experimental de tipo antes y después, en la consulta de urgencias estomatológica del policlínico Previsora desde septiembre de 2008 hasta abril de 2009, el universo de estudio se conformó por los pacientes que acudieron a la consulta con dolor producido por pulpitis aguda, la muestra quedó se integró por 40 pacientes que no habían recibido tratamiento previo. Se evaluó la intensidad del dolor a los 30min y se valoró la cooperación del paciente durante el tratamiento convencional. Resultados: en el 90 por ciento de los casos se evaluó como eficaz el tratamiento realizado y los pacientes refirieron sentirse satisfechos.

Patients with acute pulpitis caused to the pain that characterizes it, in occasions allow carrying out a satisfactory endodontic treatment of urgency. Objective: to evaluate the analgesic action of digitopuncture previous to the conventional stomatological treatment in acute pulpitis. Method: a before and after type quasi-experimental, evaluation study was performed, in the stomatological urgency consultation at Previsora polyclinic from September 2008 to April 2009, the study universe was conformed by patients that came to the consultation with pain caused by acute pulpitis and the sample was integrated by 40 patients who had not received previous treatment. The intensity of pain was evaluated to 30 minutes and patient's cooperation was valued during the conventional treatment. Results: in 90 percent of cases was evaluated as effective the treatment carried out and patients referred to feel satisfied with the treatment received (90 percent).

Manejo Holístico Rehabilitador del paciente con Enfermedad de Parkinson / Rehabilitative Holistic management of the patient with Parkinsons disease

Se realizó una revisión bibliográfica sobre el manejo del paciente en la enfermedad de Parkinson. Se describieron de forma breve los pilares del tratamiento de rehabilitación y las posibles técnicas de Medicina Tradicional y Natural que deben complementar el manejo integral de dichos pacientes, con toda la información se conformó una propuesta de manejo holístico rehabilitador de estos pacientes (AU)

A bibliographical review on the patient's management of the Parkinsons disease was performed. In a brief way the pillars of the rehabilitation treatment and possible techniques of Traditional and Natural Medicine that should complement the integral management of this patients were described, with all the information it was conformed a proposal of these patients' holistic rehabilitative management (AU)

Manejo holístico rehabilitador del paciente con enfermedad de Parkinson / Rehabilitative holistic management of the patient with Parkinson’s disease

Se realizó una revisión bibliográfica sobre el manejo del paciente en la enfermedad de Parkinson. Se describieron de forma breve los pilares del tratamiento de rehabilitación y las posibles técnicas de Medicina Tradicional y Natural que deben complementar el manejo integral de dichos pacientes, con toda la información se conformó una propuesta de manejo holístico rehabilitador de estos pacientes.

A bibliographical review on the patient's management of the Parkinson’s disease was performed. In a brief way the pillars of the rehabilitation treatment and possible techniques of Traditional and Natural Medicine that should complement the integral management of this patients were described, with all the information it was conformed a proposal of these patients' holistic rehabilitative management.

La terapia homeopática y su aplicación en la Estomatología / The homeopathic therapy and its application in Odontology

Se realizó una revisión bibliográfica con el objetivo de profundizar los conocimientos sobre la terapia homeopática y su aplicación en la estomatología, describir los principios básicos en los que se sustenta esta doctrina, los principales medicamentos de uso estomatológico y sus indicaciones. La homeopatía es el arte de curar que se basa en los principios básicos de: similitud, remedio único y dosis infinitesimales. El medicamento homeopático no presenta los inconvenientes y contraindicaciones de muchos medicamentos alopáticos, modifica la predisposición del organismo hacia la producción de la enfermedad una vez que se logra la armonía de la energía vital. Los mismos se originan de sustancias naturales puras de los reinos de la naturaleza: animal, vegetal, mineral y de productos patológicos. Para su uso deben estar altamente diluidos y activados, lo que aumenta su capacidad curativa. Los más utilizados en nuestra especialidad son: aconitum napelus, arnica montana, belladonna, caléndula, hepar sulphur, silícea, hyperycum perforatum, nux vómica, phosphorus, natrum muriaticum entre otros(AU)

A bibliographical review with the objective of deepening the knowledge on the homeopathic therapy and its application in Odontology was performed, to describe the basic principles in which it is sustained this doctrine, the main medications of stomatological use and its indications. The homeopathy is the art of curing that it is based on the basic principles of: similarity, unique remedy and infinitesimal dose. The homeopatic medication doesn't present the inconveniences and contraindications of many allopathic medications does, it modifies the predisposition of the organism towards the production of the disease once the harmony of the vital energy is achieved. The same ones arising from natural pure substances of the nature: animal, vegetable, mineral and pathological products. For its use should be highly diluted and activated, what its healing capacity increases. The most used in our specialty are: aconitum napelus, arnica montana, belladonna, calendula, hepar sulphur, silícea, hyperycum perforatum, nux vómica, phosphorus, natrum muriaticum among other(AU)

La terapia homeopática y su aplicación en la estomatología: [revisión] / The homeopathic therapy and its application in odontology: [review]

Se realizó una revisión bibliográfica con el objetivo de profundizar los conocimientos sobre la terapia homeopática y su aplicación en la estomatología, describir los principios básicos en los que se sustenta esta doctrina, los principales medicamentos de uso estomatológico y sus indicaciones. La homeopatía es el arte de curar que se basa en los principios básicos de: similitud, remedio único y dosis infinitesimales. El medicamento homeopático no presenta los inconvenientes y contraindicaciones de muchos medicamentos alopáticos, modifica la predisposición del organismo hacia la producción de la enfermedad una vez que se logra la armonía de la energía vital. Los mismos se originan de sustancias naturales puras de los reinos de la naturaleza: animal, vegetal, mineral y de productos patológicos. Para su uso deben estar altamente diluidos y activados, lo que aumenta su capacidad curativa. Los más utilizados en nuestra especialidad son: aconitum napelus, arnica montana, belladonna, caléndula, hepar sulphur, silícea, hyperycum perforatum, nux vómica, phosphorus, natrum muriaticum entre otros.

A bibliographical review with the objective of deepening the knowledge on the homeopathic therapy and its application in Odontology was performed, to describe the basic principles in which it is sustained this doctrine, the main medications of stomatological use and its indications. The homeopathy is the art of curing that it is based on the basic principles of: similarity, unique remedy and infinitesimal dose. The homeopatic medication doesn't present the inconveniences and contraindications of many allopathic medications does, it modifies the predisposition of the organism towards the production of the disease once the harmony of the vital energy is achieved. The same ones arising from natural pure substances of the nature: animal, vegetable, mineral and pathological products. For its use should be highly diluted and activated, what its healing capacity increases. The most used in our specialty are: aconitum napelus, arnica montana, belladonna, calendula, hepar sulphur, silícea, hyperycum perforatum, nux vómica, phosphorus, natrum muriaticum among other.

Eficacia del tratamiento homeopático en la estomatitis subprótesis / Efficacy of the homeopathic treatment in the subprosthesis stomatitis

Fundamento: La estomatitis subprotésica es una afección que produce cambios inflamatorios intrabucales, restringidos a la mucosa que cubre una prótesis dental. Objetivo: Determinar la eficacia de la homeopatía en el tratamiento de la estomatitis subprótesis. Método: Se realizó un ensayo clínico fase II (exploración terapéutica), abierto en el Policlínico Ignacio Agramonte entre enero y octubre de 2007, en pacientes mayores de 20 años, de ambos sexos, portadores de estomatitis subprótesis. Para la selección de estos pacientes se tuvieron en cuenta los criterios de diagnóstico, inclusión y exclusión. La muestra para el estudio quedó constituida por 35 pacientes que cumplieron con los criterios descritos anteriormente. Resultados: Esta afección prevaleció en el grupo de edades de más de 60 años con 13 pacientes, de los cuales 10 pertenecieron al sexo femenino (28,57 por ciento), y el masculino en el grupo de 50 a 59 años con seis enfermos (17,14 por ciento). Al relacionar el tiempo de curación y el grado de la lesión se encontró que dentro de los primeros 14 días de tratamiento la mayoría de los pacientes se curaron. El 100 por ciento de los pacientes del grado I se curó y los del grado II lo lograron en el 95,83 por ciento. De forma general el 97,13 por ciento de los pacientes eliminó la estomatitis subprótesis. Conclusiones: Prevaleció el sexo femenino, el grupo de edades más afectado fue el de más de 60 años. Se comprobó que la homeopatía es eficaz en el tratamiento de la estomatitis subprótesis.

The subprosthetic stomatitis is an affection that produces intrabucal inflammatory changes, restricted to the mucous membrane that covers a dental prosthesis. Objective: To determine the efficacy of the homeopathy in the subprosthesis stomatitis treatment. Method: An open phase II (therapeutic exploration) clinical trial was conducted, at ®Ignacio Agramonte¼ Polyclinic from January to October 2007, in patients older than 20 years, from both sexes, carriers of subprosthesis stomatitis. For the selection of these patients it were kept in mind the diagnosis, inclusion and exclusion criteria. The sample for the study remained constituted by 35 patients that complied with the criteria described previously.

Eficacia del tratamiento homeopático en la estomatitis subprótesis / Efficacy of the homeopathic treatment in the subprosthesis stomatitis

Fundamento: La estomatitis subprotésica es una afección que produce cambios inflamatorios intrabucales, restringidos a la mucosa que cubre una prótesis dental. Objetivo: Determinar la eficacia de la homeopatía en el tratamiento de la estomatitis subprótesis. Método: Se realizó un ensayo clínico fase II (exploración terapéutica), abierto en el Policlínico Ignacio Agramonte entre enero y octubre de 2007, en pacientes mayores de 20 años, de ambos sexos, portadores de estomatitis subprótesis. Para la selección de estos pacientes se tuvieron en cuenta los criterios de diagnóstico, inclusión y exclusión. La muestra para el estudio quedó constituida por 35 pacientes que cumplieron con los criterios descritos anteriormente. Resultados: Esta afección prevaleció en el grupo de edades de más de 60 años con 13 pacientes, de los cuales 10 pertenecieron al sexo femenino (28,57 por ciento), y el masculino en el grupo de 50 a 59 años con seis enfermos (17,14 por ciento). Al relacionar el tiempo de curación y el grado de la lesión se encontró que dentro de los primeros 14 días de tratamiento la mayoría de los pacientes se curaron. El 100 por ciento de los pacientes del grado I se curó y los del grado II lo lograron en el 95,83 por ciento. De forma general el 97,13 por ciento de los pacientes eliminó la estomatitis subprótesis. Conclusiones: Prevaleció el sexo femenino, el grupo de edades más afectado fue el de más de 60 años. Se comprobó que la homeopatía es eficaz en el tratamiento de la estomatitis subprótesis(AU)

The subprosthetic stomatitis is an affection that produces intrabucal inflammatory changes, restricted to the mucous membrane that covers a dental prosthesis. Objective: To determine the efficacy of the homeopathy in the subprosthesis stomatitis treatment. Method: An open phase II (therapeutic exploration) clinical trial was conducted, at «Ignacio Agramonte¼ Polyclinic from January to October 2007, in patients older than 20 years, from both sexes, carriers of subprosthesis stomatitis. For the selection of these patients it were kept in mind the diagnosis, inclusion and exclusion criteria. The sample for the study remained constituted by 35 patients that complied with the criteria described previously(AU)

Tratamiento homeopático en la fase aguda de la estomatitis aftosa recurrente / Homeopathic treatment in the acute phase of the recurrent aphtous stomatitis

Se realizó un ensayo clínico fase II temprana (estudio experimental) para determinar la eficacia de los remedios homeopáticos seleccionados durante la fase aguda de la estomatitis aftosa recurrente en la Clínica Estomatológica Provincial Docente Ismael Clark y Mascaró. La muestra quedó constituida por cuarenta pacientes según criterios diagnóstico, inclusión y exclusión a los cuales teniendo en cuenta modalización de los síntomas agudos se les indicó uno de los remedios homeopáticos, como el borax, el arsenicum album, el mercurius solubilis a una dinamodilución 30 CH, cinco gotas sublinguales tres veces al día hasta remitir las lesiones por cinco días. Se consideraron dos etapas para la evaluación del tratamiento a los dos y cinco días de comenzado el mismo. Los resultados se evaluaron clínicamente de acuerdo a la escala establecida por los autores. La eficacia de los remedios homeopáticos fue significativa con predominio de la respuesta satisfactoria. En la primera visita de evolución la mayoría de los síntomas presentados remitieron, se redujo la cantidad de aftas y todas las lesiones disminuyeron su diámetro hasta desaparecer la mayoría en la segunda visita, excepto una que persistió pero disminuida de tamaño. Se identificaron agravaciones homeopáticas la cefalea fue la más frecuente(AU)