ABSTRACT
Breast cancer is the second most common malignancy among women. Ilex paraguariensis A. St. Hil, known as yerba mate, is widely consumed in southern Brazil as a hot infusion drink known as chimarrão. This herb has a complex chemical composition and is rich in antioxidants, which may interfere in the course of chronic inflammatory diseases as breast cancer. This study investigated the impact of chimarrão consumption on the clinicopathological profile of women with breast cancer attended at Francisco Beltrão Cancer Hospital, Paraná, Brazil. Blood antioxidants and caffeine profiles were assessed. Decreases in reduced glutathione and metallothionein levels, and increase in catalase activity were observed among breast cancer patients that were chimarrão consumers. The levels of circulating caffeine in breast cancer patients with luminal A tumors were higher than those in patients with luminal B and HER-2 subtypes. Furthermore, overweight patients presented higher caffeine levels than the eutrophic ones. It was found positive associations between chimarrão intake and high body mass index, and chimarrão intake and menopause at diagnosis. Altogether, these findings suggest that chimarrão consumption affects the blood antioxidants of breast cancer patients, and that the caffeine present in this mixture may favor the development of tumor of good prognosis. HIGHLIGHTS: Chimarrão consumption may affect the course of chronic inflammatory diseases, as breast cancer. Chimarrão intake changed blood antioxidants in breast cancer patients who were current consumers when compared to the non-consumers ones. High levels of caffeine were detected in patients bearing luminal A tumors, suggesting a protective role.
Subject(s)
Antioxidants/therapeutic use , Breast Neoplasms/drug therapy , Caffeine/therapeutic use , Plant Leaves/chemistry , Female , Humans , Male , Middle Aged , PrognosisABSTRACT
As doenças cardiovasculares têm apresentado grande importância dentro da saúde pública, frente ao seu enorme impacto social e econômico. Os fatores de risco para estas doenças tem acompanhado o portador do Diabetes Mellitus, representando a principal causa de morbimortalidade nesta população. O presente trabalho teve como finalidade levantar a prevalência dos fatores de risco das complicações do Diabetes, que podem levar a doenças cardiovasculares. O estudo avaliou um grupo de 53 diabéticos (tipo 2) atendidos por uma equipe do Programa Saúde da Família (PSF) em Paranavaí, Paraná. A avaliação incluiu avaliação socioeconômica, antropométrica, pressórica e bioquímica. O estudo demonstrou uma elevada prevalência de vários fatores de risco, como pressão arterial, dislipidemias, hiperglicemia e excesso de peso, tanto em homens, quanto em mulheres. Considerando a coexistência de fatores de risco, foi possível identificar uma alta prevalência de portadores da síndrome metabólica. Desta forma, o estudo reforça a necessidade da melhoria do acompanhamento destes pacientes, visando ao controle metabólico e à redução da distribuição de gordura corporal, buscando evitar as complicações que acompanham o diabetes, assim como a implantação de programas de intervenção e educação através do PSF, com finalidade de reduzir o ônus do sistema público.
Cardiovascular diseases have shown great importance within public health as a result of its enormous social and economic impact. The risk factors for such diseases have followed the patients with type 2 diabetes Mellitus, representing the major cause of their morbimortality. This paper studies the prevalence of the consequences of Diabetes which can lead to cardiovascular diseases. This study evaluates a group of 53 patients with type 2 diabetes Mellitus assisted by a team of the Health Family Program in Paranavaí, Paraná, Brazil. The evaluation included socioeconomic conditions, anthropometric, biochemical and blood pressure levels. The study showed high prevalence of several risk factors such as blood pressure, dyslipidemia, hyperglycemia and weight excess for both genders. Considering the coexistence of risk factors, we identified wide prevalence of patients with metabolic syndrome. Thus, this study suggests the need for improved monitoring of patients in order to control their metabolic parameters and reduce their body fat distribution to avoid the complications from diabetes. This paper still suggests the need for interventions and educational programs through the Health Family Program to reduce the expenses of the public system.
