Informal helpers' responses when adolescents tell them about dating violence or romantic relationship problems.

This study examines the responses of informal helpers to adolescents who disclose dating violence or upsetting but non-violent experiences in their romantic relationships. Based on a survey of 224 Midwestern high school students, the study found that youths were more likely to disclose problems to friends rather than others. A factor analysis of potential helpers' responses showed that, compared to avoidance and minimization, nurturing was the most typical response received. Adolescents who told someone about being victimized by severe dating violence were more likely to receive an avoidance response than those who told about less severe dating violence. Males encountered high levels of minimization regarding less severe dating violence. While friends and family seem to respond effectively to romantic relationship problems, youths need more training in how to respond helpfully to friends' difficulties with dating violence or how to encourage victims to seek help from trained practitioners.

Vascular gene expression in nonneoplastic and malignant brain.

Malignant gliomas are uniformly lethal tumors whose morbidity is mediated in large part by the angiogenic response of the brain to the invading tumor. This profound angiogenic response leads to aggressive tumor invasion and destruction of surrounding brain tissue as well as blood-brain barrier breakdown and life-threatening cerebral edema. To investigate the molecular mechanisms governing the proliferation of abnormal microvasculature in malignant brain tumor patients, we have undertaken a cell-specific transcriptome analysis from surgically harvested nonneoplastic and tumor-associated endothelial cells. SAGE-derived endothelial cell gene expression patterns from glioma and nonneoplastic brain tissue reveal distinct gene expression patterns and consistent up-regulation of certain glioma endothelial marker genes across patient samples. We define the G-protein-coupled receptor RDC1 as a tumor endothelial marker whose expression is distinctly induced in tumor endothelial cells of both brain and peripheral vasculature. Further, we demonstrate that the glioma-induced gene, PV1, shows expression both restricted to endothelial cells and coincident with endothelial cell tube formation. As PV1 provides a framework for endothelial cell caveolar diaphragms, this protein may serve to enhance glioma-induced disruption of the blood-brain barrier and transendothelial exchange. Additional characterization of this extensive brain endothelial cell gene expression database will provide unique molecular insights into vascular gene expression.

Violence during pregnancy among women with or at risk for HIV infection.

OBJECTIVES: This study estimated the prevalence of violence during pregnancy in relation to HIV infection. METHODS: Violence, current partnerships, and HIV risk behaviors were assessed among 336 HIV-seropositive and 298 HIV-seronegative at-risk pregnant women. RESULTS: Overall, 8.9% of women experienced recent violence; 21.5% currently had abusive partners. Violence was experienced by women in all partnership categories (range = 3.8% with nonabusive partners to 53.6% with physically abusive partners). Neither experiencing violence nor having an abusive partner differed by serostatus. Receiving an HIV diagnosis prenatally did not increase risk. Disclosure-related violence occurred, but was rare. CONCLUSIONS: Many HIV-infected pregnant women experience violence, but it is not typically attributable to their serostatus. Prenatal services should incorporate screening and counseling for all women at risk for violence.