ABSTRACT
Autonomic dysfunction, hypertension and cardiovascular morbidity in end stage renal disease are critically linked, however there are limited models available to investigate this relationship and develop clinical interventions. This study aimed to define the relationship between hypertension and autonomic function in a new rodent model of polycystic kidney disease (PKD). Using measures of heart rate and systolic blood pressure variability (HRV, SBPV), and time domain analysis of cardiac and sympathetic baroreflex function, we compared the Lewis PKD model (LPK) to a Lewis control. Systolic BP and SBPV were significantly higher in LPK vs. Lewis (168+/-7 vs. 131+/-8mm Hg, PSubject(s)
Autonomic Nervous System/physiopathology
, Cardiovascular System/innervation
, Cardiovascular System/physiopathology
, Hypertension/physiopathology
, Polycystic Kidney, Autosomal Recessive/physiopathology
, Animals
, Antihypertensive Agents/pharmacology
, Atenolol/pharmacology
, Atropine Derivatives/pharmacology
, Baroreflex/drug effects
, Baroreflex/physiology
, Blood Pressure/drug effects
, Disease Models, Animal
, Electrophysiologic Techniques, Cardiac/methods
, Fourier Analysis
, Heart Rate/drug effects
, Hypertension/drug therapy
, Male
, Nitroprusside/pharmacology
, Parasympatholytics/pharmacology
, Rats
, Rats, Inbred Lew
, Signal Processing, Computer-Assisted
