ABSTRACT
In this experimental study we have investigated whether the inclusion of the dietary fiber Plantago ovata husk could be recommended as coadjuvant in treatments with oral hypoglycemic drugs. We evaluated the use of Plantago ovata husk-metformin association in diabetic rabbits by determining its effects on glucose and insulin concentrations. Six groups of 6 rabbits were used. Groups 1 to 3 were fed with standard chow and groups 4 to 6 with chow supplemented with Plantago ovata husk (3.5 mg/kg/day). Two groups (numbers 1 and 4) were used as controls (receiving standard or supplemented chow), two groups (numbers 2 and 5) received metformin orally, and the other two (numbers 3 and 6) were treated orally with metformin and psyllium. Plasma glucose concentrations were lower in groups fed with fiber-supplemented chow whereas insulin levels showed important interindividual variations. Glucose pharmacokinetics parameters showed significant differences in Cmax and t(max) in relation to fiber intake. Insulin pharmacokinetics parameters after treatment with oral metformin showed an important increase in Cmax, AUC, and t(max) in animals fed with fiber. We conclude that Plantago ovata husk intake can contribute to the oral antihyperglycemic treatment of type 2 diabetes.
Subject(s)
Blood Glucose/metabolism , Diabetes Mellitus, Experimental/drug therapy , Dietary Fiber , Hypoglycemic Agents/therapeutic use , Metformin/therapeutic use , Phytotherapy , Plantago , Administration, Oral , Animals , Diabetes Mellitus, Experimental/blood , Drug Therapy, Combination , Insulin/blood , Rabbits , Treatment OutcomeSubject(s)
Attitude of Health Personnel , Noise/adverse effects , Nursing Staff, Hospital/psychology , Burnout, Professional/etiology , Burnout, Professional/psychology , Fatigue/etiology , Fatigue/psychology , Health Facility Environment , Health Services Needs and Demand , Hospital Communication Systems , Humans , Noise/prevention & control , Nurse Administrators , Nursing Methodology Research , Occupational Diseases/etiology , Occupational Diseases/psychology , Occupational Health , Quality of Life/psychology , Risk Factors , Sleep Disorders, Circadian Rhythm/etiology , Sleep Disorders, Circadian Rhythm/psychology , Sound Spectrography , Spain , Surveys and Questionnaires , Time Factors , Work Schedule ToleranceABSTRACT
Objetivo: conocer cómo los pacientes perciben el ruido y su influencia durante la estancia hospitalaria. Este trabajo forma parte de una línea de investigación sobre condiciones medio-ambientales de los hospitales. Material y métodos: estudio descriptivo transversal a través de un cuestionario con ítems que hacían referencia a la fuente sonora, horario y características del ruido. La población fue de 193 pacientes pertenecientes a 4 hospitales dedistintas categorías y provincias. Los servicios seleccionados, atendiendo a su intensa y diferenteactividad asistencial fueron: Cuidados Intensivos,Servicio de Cirugía y Servicio de Pediatría. Resultados: la fuente que más molestaba a los pacientes eran las propias personas cuando hablaban alto con un 64,8%, la franja horaria donde se registró mayor percepción del ruido fue de 9-21h con un 77%, sin embargo, molestabamás en la noche con un 31,1% o incluso por la tarde y especialmente cuando sentían dolor (28,5%). Las características del ruido más molestas para los pacientes eran el alto volumen y aquellos que se repetían muchas veces (35,2%). Conclusiones: la mayor percepción del ruido tiene su origen en fuentes fácilmente accesibles y no excesivamente costosas para el diseño de medidas correctoras como son el tono de voz de las personas y las alarmas. La propuesta del equipo investigador es la educación en hábitos, normas y conductas que faciliten un entorno acústico más armonioso y el estudio de propuestaarquitectónicas para sustituir señales ruidosas por luminosas, en la medida de lo posible
Objective: to ascertain how patients perceive noise and its influence on their hospital stay. This work is part of a research line on the environmental conditions of hospitals. Material and methods: cross-sectional descriptive study through a questionnaire with item referring to the noise source, time schedule andcharacteristics of noise. The population included 193 patients pertaining to 4 different category hospitals and provinces. The selected services, attending to their different work volume, were: Intensive Care Unit, Department of Surgery and Department of Paediatrics. Results: the noise source that most bothered the patients was the actual people when they talked loud with a 64,8%, the time area where the highest level of sound was noted was between 9 and 21 hours, with 77% of the noise, nonetheless, it was more bothersome during the night,with a 31% or even in the late afternoon, being aggravated when the patients were in pain (28,5%). The characteristics of the worst noise were high volume and those that repeated the same sounds over and over again (35,2%). Conclusions: the greatest perception of noise originates in easily accessible sources. These sourcesare however, not that expensive to fix by implementingcorrective measures such as telling people to speak more softly and to turn down alarms. The proposal presented by the research team is education in habits, norms and behaviours aimed at facilitating a more harmonious acoustic surrounding and the study of architectonic proposals to replace noisy signals by light signals, to the extent such change might be possible
