Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 4 de 4
Filter
Add more filters










Publication year range
1.
Rev. esp. cir. ortop. traumatol. (Ed. impr.) ; 64(5): 301-309, sept.-oct. 2020. ilus, tab, graf
Article in Spanish | IBECS | ID: ibc-197608

ABSTRACT

ANTECEDENTES Y OBJETIVO: Los sarcomas de partes blandas se localizan excepcionalmente en la región del codo. El objetivo de este trabajo fue estudiar los sarcomas de partes blandas de la región del codo, sus características epidemiológicas e histopatológicas, particularidades anatómicas, tratamiento realizado y resultados obtenidos, en una Unidad de Tumores Musculoesqueléticos. MATERIALES Y MÉTODOS: Revisión retrospectiva de 10 pacientes con un seguimiento de 65,0 ± 11,9 (rango 21-132) meses con sarcoma de partes blandas situado en la región del codo, intervenidos en nuestro centro entre los años 2008 y 2016. RESULTADOS: La edad media fue de 60,8 ± 6,7 años. La histología más frecuente fue sarcoma pleomórfico indiferenciado. El 90% de los pacientes fueron sometidos a cirugía de preservación de extremidad. Tres pacientes fueron previamente intervenidos sin criterios oncológicos en otro centro, y esto se relacionó de forma estadísticamente significativa con requerir más de una cirugía para el control de la enfermedad. En cinco pacientes se obtuvo un margen R1 y en cinco R0. La radioterapia adyuvante se utilizó en siete casos. En cuatro pacientes se realizó cirugía posterior para control local o sistémico de la enfermedad. En tres casos se produjo recidiva local y en cinco se presentó enfermedad a distancia. CONCLUSIONES: La región del codo presenta dificultad para lograr márgenes amplios por la proximidad de estructuras neurovasculares, por lo que las terapias adyuvantes, neoadyuvantes (o ambas) podrían tener un papel importante para poder realizar una cirugía de preservación de la extremidad. Sería recomendable remitir estos tumores a unidades especializadas con equipos multidisciplinarios


BACKGROUND AND AIM: Soft tissue sarcomas are exceptionally located in the elbow region. The aim of this work was to study the soft tissue sarcomas of the elbow region, their epidemiological and histopathological characteristics, anatomical features, the treatment performed, and the results obtained, in a unit of musculoskeletal tumours. METHODS: Retrospective review of ten patients with a mean follow-up of 65.0 ± 11.9 (range 21-132) months with soft tissue sarcomas located in the elbow region operated in our centre between 2008 and 2016. RESULTS: Mean age was 60.8 ± 6.7 years. Undifferentiated pleomorphic sarcoma was the most frequent histological diagnosis. Limb preservation surgery was performed in 90% of patients. Three patients were previously operated without following surgical oncology guidelines in another hospital, and this was statistically related to the need for more than one surgery to control the disease. R1 margin was obtained in 5 patients and R0 in another 5. Adjuvant radiotherapy was used in 7 cases. In 4 patients, subsequent surgery was performed for local or systemic control of the disease. Local recurrence occurred in 3 cases and in 5 there was distant disease. CONCLUSION: The elbow region presents difficulty in achieving wide margins due to the proximity of neurovascular structures, adjuvant and / or neoadjuvant therapies could play an important role in performing limb preservation surgery. It would be advisable to refer these tumours to specialized units with multidisciplinary teams


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Sarcoma/pathology , Soft Tissue Neoplasms/pathology , Elbow/pathology , Retrospective Studies , Elbow/anatomy & histology , Chemotherapy, Adjuvant/methods , Chemoradiotherapy, Adjuvant/methods , Neoadjuvant Therapy/methods
2.
Article in English, Spanish | MEDLINE | ID: mdl-32561206

ABSTRACT

BACKGROUND AND AIM: Soft tissue sarcomas are exceptionally located in the elbow region. The aim of this work was to study the soft tissue sarcomas of the elbow region, their epidemiological and histopathological characteristics, anatomical features, the treatment performed, and the results obtained, in a unit of musculoskeletal tumours. METHODS: Retrospective review of ten patients with a mean follow-up of 65.0 ± 11.9 (range 21-132) months with soft tissue sarcomas located in the elbow region operated in our centre between 2008 and 2016. RESULTS: Mean age was 60.8 ± 6.7 years. Undifferentiated pleomorphic sarcoma was the most frequent histological diagnosis. Limb preservation surgery was performed in 90% of patients. Three patients were previously operated without following surgical oncology guidelines in another hospital, and this was statistically related to the need for more than one surgery to control the disease. R1 margin was obtained in 5 patients and R0 in another 5. Adjuvant radiotherapy was used in 7 cases. In 4 patients, subsequent surgery was performed for local or systemic control of the disease. Local recurrence occurred in 3 cases and in 5 there was distant disease. CONCLUSION: The elbow region presents difficulty in achieving wide margins due to the proximity of neurovascular structures, adjuvant and / or neoadjuvant therapies could play an important role in performing limb preservation surgery. It would be advisable to refer these tumours to specialized units with multidisciplinary teams.


Subject(s)
Elbow , Sarcoma , Soft Tissue Neoplasms , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Retrospective Studies , Sarcoma/epidemiology , Sarcoma/pathology , Sarcoma/therapy , Soft Tissue Neoplasms/epidemiology , Soft Tissue Neoplasms/pathology , Soft Tissue Neoplasms/therapy
3.
Int J Immunopharmacol ; 20(10): 521-35, 1998 Oct.
Article in English | MEDLINE | ID: mdl-9839657

ABSTRACT

Reactivation of varicella herpes virus (VHV), latent in individuals who have previously suffered varicella, gives rise to herpes zoster and in some cases leads to a sequela of post herpetic neuritis with severe pain which is refractory to analgesics. Many different antiviral agents have been tried without achieving satisfactory results. Of all the antiviral agents employed, acyclovir has been the most successful in reducing post herpetic pain. However acyclovir has not been as reliable as interferon alpha (IFN-alpha). We have previously looked into the use of transfer factor (TF) as a modulator of the immune system, specifically with respect to its effectiveness in the treatment of herpes zoster. In this work findings from a comparative clinical evaluation are presented. A double blind clinical trial of TF vs acyclovir was carried out in which 28 patients, presenting acute stage herpes zoster, were randomly assigned to either treatment group. Treatment was administered for seven days and the patients were subsequently submitted to daily clinical observation for an additional 14 days. An analogue visual scale was implemented in order to record pain and thereby served as the clinical parameter for scoring results. The group treated with TF was found to have a more favorable clinical course, P < or = 0.015. Laboratory tests to assess the immune profile of the patients were performed two days prior and 14 days after initial treatment. The results of these tests showed an increase in IFN-gamma levels, augmentation in the CD4+ cell population but not the percentage of T rosettes in the TF treated group. These parameters were however insignificantly modified in patients receiving acyclovir. Although TF treated patients showed an increase in CD4+ counts these cells remained below the levels for healthy individuals. The fact that IFN-gamma levels as well as the counts for CD4+ cells rose in the TF treated group and not in the acyclovir one is very significant and confirms the immunomodulating properties of TF.


Subject(s)
Acyclovir/therapeutic use , Antiviral Agents/therapeutic use , Herpes Zoster/therapy , Herpesvirus 3, Human , Transfer Factor/therapeutic use , CD4-CD8 Ratio , Double-Blind Method , Female , Herpes Zoster/immunology , Herpesvirus 3, Human/drug effects , Humans , Interferon-gamma/immunology , Male , T-Lymphocytes/immunology
4.
Surg Gynecol Obstet ; 141(4): 611-4, 1975 Oct.
Article in English | MEDLINE | ID: mdl-1166394

ABSTRACT

For anal incontinence caused by destroyed or absent sphincter mechanism, a levator sling serving as a substitute puborectalis sling was used in five patients with incontinence of varied causes with good to excellent results. This sling was constructed bu freeing the insertion of the pubococcygeus and the ileococcygeus muscles from the coccyx. By further freeing the arcus tendineus from the lateral wall of the pelvis, the sling is made to arise from the pubis, thus theoretically giving the sling the potential of greater traction.


Subject(s)
Fecal Incontinence/surgery , Humans , Methods
SELECTION OF CITATIONS
SEARCH DETAIL
...