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Chem Commun (Camb)
; 57(83): 10867-10870, 2021 Oct 19.
Article
in English
| MEDLINE
| ID: mdl-34665184
ABSTRACT
A new CEST-MRI contrast agent, 2-HYNIC, capable of sensing aromatic aldehydes is reported. Pyridoxal 5'-phosphate, a key Vitamin B6 metabolite necessary for >140 biotransformations was mapped by CEST-MRI in vitro and in vivo in lung cancer. 2-HYNIC provided access to this key biomarker associated with a variety of human diseases.
