Association between polymorphisms in the thymidylate synthase gene and risk of breast cancer in a Mexican population.

Breast cancer (BC) is the leading cause of cancer-related deaths among women in Mexico. Two single-nucleotide polymorphisms (SNPs) in the thymidylate synthase (TS) gene, the 28-base pair (bp) tandem repeat in the TS 5'-untranslated enhanced region (TSER) and the 6-bp insertion/deletion in the TS 3'-untranslated region (TS 3'-UTR), increase the rate of misincorporation of uridylate into DNA and may lead to chromosomal damage. We examined the association between these polymorphisms and BC risk in Mexican women according to menopause status. Mexican patients with initial BC diagnosis (N = 230) and 145 individuals from a reference general population group (RGP) were included. For statistical analysis, the BC group was divided into pre- and post-menopause groups (PRE and POST groups, respectively). We analyzed both TS polymorphisms (TSER and TS 3'-UTR) using polymerase chain reaction. Finetti analysis was used to evaluate inter-and intra-group differences. The results showed a high frequency for the 3R and ins6 alleles in the BC, RGP, PRE, and POST groups. No significant differences were observed for the TS and TSER genotype and allele frequency distributions between groups. We found that the TSER and TS 3'-UTR SNPs are not associated with BC risk in Mexican patients.

Tratamiento del craneofaringioma quístico con 90Y-coloide. Presentación de 4 casos clínicos / Treatment of cystic craniopharyngioma with 90Y-Colloid. Four clinical cases

El craneofaringioma es un tumor intracraneal histológicamente benigno y frecuentemente quístico que puede presentar un comportamiento agresivo por compresión de estructuras vecinas. Su manejo terapéutico es complicado ya que si bien el tratamiento de elección suele ser la cirugía, esta no está exenta de una gran morbimortalidad y recidiva tumoral frecuente. En aquellos craneofaringiomas con un componente quístico importante la irradiación interna del tumor con isótopos radiactivos supone una alternativa a los tratamientos convencionales. Se presentan 4 casos de pacientes con craneofaringiomas quísticos tratados mediante administración intraquística con 90Y-coloide y su evolución después del tratamiento(AU)

Craniopharyngioma is a histologically benign and frequently cystic intracranial tumor. It may present aggressive behavior due to compression of nearby structures. Its therapeutic management is complicated because, although surgery is the usual treatment of choice, it is not exempt of high morbidity and mortality, and frequent tumor recurrence. In craniopharyngiomas with a significant cystic component, internal irradiation with radioactive isotopes is a therapeutic alternative to conventional treatments. We present the cases of four patients with cystic craniopharyngiomas who were treated with intracystic administration of 90Y-colloid, and their evolution after the therapy(AU)

Treatment of cystic craniopharyngioma with 90Y-Colloid. Four clinical cases.

Craniopharyngioma is a histologically benign and frequently cystic intracranial tumor. It may present aggressive behavior due to compression from nearby structures. Its therapeutic management is complicated because although surgery is the usual treatment of choice, it is not exempt of high morbidity and mortality and frequent tumor recurrence. In craniopharyngiomas with a significant cystic component,internal irradiation with radioactive isotopes is a therapeutic alternative to conventional treatments. We present the cases of four patients with cystic craniopharyngiomas who were treated with intracystic administration of 90Y-colloid, and their evolution after the treatment.

Binding of gamma-aminobutyric acid and taurine to synaptosomal fractions of regions of the feline CNS.

The "binding" of 3H-gamma-aminobutyric acid (3H-GABA) and 14C-taurine (7 X 10(-5) M) to synaptosomal fractions of the feline CNS was studied using differential centrifugation and double-isotope methods. Of the regions examined, the "binding" of GABA (in nmole/mg protein) occurred to the greatest extent, in cerebral cortex, olfactory bulb, and colliculi and, to a lesser extent, in caudate nucleus, corona radiata, and fornix. Distribution ratios revealed that GABA binding was greater in the cerebral cortex than in caudate nucleus, brain stem, spinal cord, and white matter regions. The binding of taurine (in nmole/mg protein) was lowest in cerebral cortex and highest in brain stem and spinal gray regions. Distribution ratios for taurine indicated that its accumulation was similar in all CNS regions studied, except for slightly higher values for cerebellar cortex and fornix. These results indicated that preferential binding of both GABA and taurine exists among regions of the feline CNS.