ABSTRACT
BACKGROUND: There are data indicating that several azonine-derivatives may exert effects on some biological systems; however, there is very low information on the biological activity induced by these compounds on left ventricular pressure. OBJECTIVE: The aim of this study was to synthesize and evaluate the biological activity of new triazoninederivative on left ventricular pressure. MATERIAL AND METHODS: The first stage involved: 1) preparation of two azepine-benzamide derivatives (Z or E) by reaction of the nitrobenzoyl azide with adrenosterone; and 2) reaction of (Z)-azepine-benzamide derivative with ethylenediamine to form the triazonine derivative. The structure of compounds was confirmed by spectroscopy and spectrometry data. The second stage involved the biologic activity on left ventricular pressure was evaluated in a model of rat heart isolated. In addition, some physicochemical parameters were evaluated to characterize the possible molecules involved in its effect. RESULTS: The results showed that only the triazonine increased left ventricular pressure via androgen receptor. CONCLUSIONS: In conclusion, this phenomenon is conditioned by the functional groups involved in the chemical structure of triazonine derivative and their interaction with residues of amino acids involved on the androgen receptor surface.
Subject(s)
Azepines/chemistry , Azepines/pharmacology , Heterocyclic Compounds, 4 or More Rings/chemistry , Heterocyclic Compounds, 4 or More Rings/pharmacology , Receptors, Androgen/metabolism , Ventricular Function, Left/drug effects , Ventricular Pressure/drug effects , Animals , Azepines/chemical synthesis , Benzamides/chemical synthesis , Benzamides/chemistry , Heterocyclic Compounds, 4 or More Rings/chemical synthesis , Humans , Male , Molecular Docking Simulation , Rats, WistarABSTRACT
From April 1995 through November 1997 a dengue epidemic occurred in Ibagué (400,000 population), Colombia, where 3,419 cases were reported and DEN 2 virus was isolated from seven patients. A sero-survey conducted in 1996 found evidence of previous dengue infection in 9.6% of the population, indicating that many infections had not been reported. The dengue infections occurred in all age groups, but children under five years of age were most frequently infected. Forty-five percent of this Ibagué population were born after the re-appearance of dengue in Colombia in 1972, but have never been infected with dengue virus. Most of the cases reported as dengue hemorrhagic fever did not fulfill the current case definition. Aedes aegypti larvae were found in 19% of dwellings surveyed, most often in uncovered low tanks used for water storage. Many residents were not acquainted with the domestic nature of the mosquito vector. Health workers attributed the failure of the dengue control programs to lack of leadership and other administrative problems.
Subject(s)
Dengue/epidemiology , Disease Outbreaks , Adolescent , Adult , Aedes , Animals , Child , Child, Preschool , Colombia/epidemiology , Female , Humans , Infant , Male , Middle Aged , Population Density , Population SurveillanceABSTRACT
From April 1995 through November 1997 a dengue epidemic occurred in Ibagué (400,000 population), Colombia, where 3,419 cases were reported and DEN 2 virus was isolated from seven patients. A sero-survey conducted in 1996 found evidence of previous dengue infection in 9.6% of the population, indicating that many infections had not been reported. The dengue infections occurred in all age groups, but children under five years of age were most frequently infected. Forty-five percent of this Ibagué population were born after the re-appearance of dengue in Colombia in 1972, but have never been infected with dengue virus. Most of the cases reported as dengue hemorrhagic fever did not fulfill the current case definition. Aedes aegypti larvae were found in 19% of dwellings surveyed, most often in uncovered low tanks used for water storage. Many residents were not acquainted with the domestic nature of the mosquito vector. Health workers attributed the failure of the dengue control programs to lack of leadership and other administrative problems.
Desde abril de 1995 a noviembre de 1997 ocurrió una epidemia de dengue en Ibagué, Tolima (400.000 habitantes), Colombia, en la cual se notificaron 3.419 casos y se aisló virus dengue 2 en el suero de 7 pacientes. En una encuesta serológica realizada en 1996 se encontró evidencia de infección anterior por dengue en 9,6% de la población, lo cual indica que muchas infecciones no se habían reportado. Las infecciones recientes del dengue ocurrieron en todos los grupos de edad, pero los niños menores de cinco años fueron más frecuentemente infectados. 45% de éstos, que nacieron después de la reemergencia del dengue en Colombia en 1972, nunca habían sido infectados con virus del dengue. La mayoría de los casos notificados de dengue hemorrágico no satisfacían la definición actual de caso. En el estudio entomológico se encontraron larvas en el 19% de las viviendas examinadas, la mayoría de las veces de Aedes aegypti en albercas destapadas, donde muchos residentes no entendían la naturaleza doméstica del mosquito vector. El personal de salud fue entrevistado y atribuyeron la falla de los programas de control del dengue a la carencia de dirección y a otros problemas administrativos.
Subject(s)
Adolescent , Adult , Animals , Child , Child, Preschool , Female , Humans , Infant , Male , Middle Aged , Disease Outbreaks , Dengue/epidemiology , Aedes , Colombia/epidemiology , Population Density , Population SurveillanceABSTRACT
En Cochabamba, Bolivia siempre han existido comunidades dedicadas exclusivamente al cultivo de las flores.a partir de los años ochenta se inicia en esta zona la floricultura para exportación, trayendo consigo un paquete tecnológico con muchas esperanzas económicas,nuevos mercados, mas empleos.El presente trabajo es resultado de estudios y experiencias recogidas por más de cuatro años en la zona florícola de Cochabamba,Bolivia: en que se pretende mostrar que ixstendimensiones en la floricultura que van allá del aroma y la belleza de las flores que en detalle se describe en los Diagnósticos:Socioeconómico, Ambiental y Salud.Diagnosticos que se dedsarrollan fundamentalmente en el transcurso de 1999-2000 y se complementaron en 2001 y 2002 y se complementaron en el 2001 y 2002
