Reflexionando con Benito Menni en el siglo XXI / No disponible

En la situación actual de crisis económica es fácil que a nivel asistencial se presenten conflictos entre distintos valores hospitalarios, debiendo priorizar unos por encima de otros. Ante esa situación se decide estudiar e investigar los valores a los que San Benito Menni daba mayor prioridad, es decir su jerarquía de valores. Para ello, se constituyó un grupo de reflexión que, a través del estudio de la abundante documentación epistolar referida al padre Menni y su enmarque en las diferencias entre el escenario socioeconómico-cultural de finales del siglo XIX y el actual, propone una metodología de consenso deductiva-inductiva cuya síntesis es una carta consejo del padre Menni dirigida a los problemas y conflictos actuales (AU)

In the current economic crisis, conflicts between different hospital values are presented. Given this situation it was decided to study and investigate the hierarchy of values of San Benito Menni. A think tank that studied the abundant epistolary documentation referred to Father Menni and its historical context and cultural socio-economic scenario (late nineteenth century and early twentyfirst century) was formed. This group uses a methodology of deductive-inductive consensus whose synthesis is a Father Menni letter addressed to current conflicts (AU)

A cluster merging method for time series microarray with production values.

A challenging task in time-course microarray data analysis is to cluster genes meaningfully combining the information provided by multiple replicates covering the same key time points. This paper proposes a novel cluster merging method to accomplish this goal obtaining groups with highly correlated genes. The main idea behind the proposed method is to generate a clustering starting from groups created based on individual temporal series (representing different biological replicates measured in the same time points) and merging them by taking into account the frequency by which two genes are assembled together in each clustering. The gene groups at the level of individual time series are generated using several shape-based clustering methods. This study is focused on a real-world time series microarray task with the aim to find co-expressed genes related to the production and growth of a certain bacteria. The shape-based clustering methods used at the level of individual time series rely on identifying similar gene expression patterns over time which, in some models, are further matched to the pattern of production/growth. The proposed cluster merging method is able to produce meaningful gene groups which can be naturally ranked by the level of agreement on the clustering among individual time series. The list of clusters and genes is further sorted based on the information correlation coefficient and new problem-specific relevant measures. Computational experiments and results of the cluster merging method are analyzed from a biological perspective and further compared with the clustering generated based on the mean value of time series and the same shape-based algorithm.

Interferência do extrato de ginkgo biloba 761 no fluxo urinário de ratos in vivo / Interference of ginkgo biloba 761 in urine flow of rats in vivo

A partir de 1984, houve a comprovação de que os ginkgolídeos, componentes do extrato de Ginkgo biloba 761 (EGb) possuem atividade potente e específica como antagonistas do fator ativador plaquetário (PAF), um importante agente mediador de reações inflamatórias em vários tipos celulares. O objetivo deste trabalho foi avaliar o efeito (in vivo) do extrato de Ginkgo biloba 761 em doses terapêuticas em um modelo animal. Os métodos empregados neste estudo foram baseados nos trabalhos de MORENO et al (2007). Utilizamos ratos Wistar de até 3 meses de idade com massa corporal entre 180 e 240 gramas. Estes animais foram submetidos nos últimos 8 dias do protocolo experimental ao extrato de ginkgo biloba 761 por via oral ...A introdução de EGb (dose terapêutica) em ratos saudáveis pode promover alterações na fisiologia do rim, mas não suficientes para modificar a arquitetura Glomerular, inclusive a nível ultra estrutural (microscopia eletrônica).