ABSTRACT
La enfermedad cardiovascular sigue siendo la primera causa de mortalidad en los países occidentales. Se necesitan nuevas estrategias para la prevención y el control de esta enfermedad. Al mismo tiempo, la incidencia de factores de riesgo que conducen al desarrollo de esta afección, como la obesidad, la hipertensión y la diabetes, sigue aumentando. Por lo tanto, la búsqueda de nuevos marcadores o mediadores es una prioridad en la mayoría de los programas de prevención cardiovascular. El estudio de la microbiota intestinal está surgiendo porque se sabe que los microorganismos intestinales actúan colectivamente como un órgano integrado, regulando múltiples funciones biológicas que pueden modular los factores de riesgo cardiovascular y los mecanismos patógenos de este proceso. Esta revisión considera la situación actual con respecto a la influencia de la microbiota intestinal en la enfermedad cardiovascular y, en particular, su influencia en los principales factores de riesgo tradicionales que conducen a la enfermedad cardiovascular, como la obesidad, la diabetes, la hipertensión y los lípidos
Cardiovascular disease remains the first cause of mortality in Western countries. New strategies for prevention and control of cardiovascular disease are needed. At the same time, the incidence of risk factors that lead to the development of this disease, such as obesity, hypertension and diabetes, continues to rise. Therefore, the search for new markers or mediators is a priority in most cardiovascular prevention programs. The study of the intestinal microbiota is emerging because it is known that intestinal microorganisms act collectively as an integrated organ, regulating multiple biological functions that can modulate cardiovascular risk factors and the pathogenic mechanisms of this process. This review considers the current situation regarding the influence of gut microbiota on cardiovascular disease and particularly, its influence on the main traditional risk factors that lead to cardiovascular disease, such as obesity, diabetes, hypertension and lipids
Subject(s)
Humans , Gastrointestinal Microbiome , Risk Factors , Cardiovascular Diseases/etiology , Cardiovascular Diseases/complications , Arteriosclerosis/complications , Arteriosclerosis/prevention & control , Obesity/epidemiologyABSTRACT
Cardiovascular disease remains the first cause of mortality in Western countries. New strategies for prevention and control of cardiovascular disease are needed. At the same time, the incidence of risk factors that lead to the development of this disease, such as obesity, hypertension and diabetes, continues to rise. Therefore, the search for new markers or mediators is a priority in most cardiovascular prevention programs. The study of the intestinal microbiota is emerging because it is known that intestinal microorganisms act collectively as an integrated organ, regulating multiple biological functions that can modulate cardiovascular risk factors and the pathogenic mechanisms of this process. This review considers the current situation regarding the influence of gut microbiota on cardiovascular disease and particularly, its influence on the main traditional risk factors that lead to cardiovascular disease, such as obesity, diabetes, hypertension and lipids.
