ABSTRACT
Recent advances in etiopathogenesis and natural history of idiopathic dilated cardiomyopathy are presented. The clinical and instrumental diagnosis and therapy are also reported.
Subject(s)
Cardiomyopathy, Dilated/genetics , Cardiomyopathy, Dilated/etiology , Cardiomyopathy, Dilated/immunology , Cardiomyopathy, Dilated/surgery , Female , Heart Transplantation , Humans , Male , Sex Ratio , X ChromosomeABSTRACT
We studied 35 patients (4 females and 31 males) suffering from acute myocardial infarction (AMI) using ergometric tests (ET), ecostress test with Dobutamin (ESD) and coronary angiography within 20 days of the onset of symptoms 5.7% of patients did not show significant coronary lesions. ET was positive in 50% of cases in this group 31.4% of patients were diagnosed with monovessel coronary disease and ET and ESD were positive for residual ischemia in 33.3% of this group. The majority of patients (42.8%) suffered from bivessel coronary disease and ET and ESD were positive for residual ischemia in 45.4% and 53.8% respectively in this group. 20% of patients presented tri-vessel coronary disease and in this group the majority of patients were positive both for ET (83.8%) and ESD (100%). In conclusion, we affirm that the percentage of positivity to challenge tests rose in parallel to the increasing number of diseased vessels, and that ET and ESD are of reciprocal value and both are fundamental in the evaluation of post-infarction residual ischemia.
Subject(s)
Coronary Disease/complications , Myocardial Infarction/complications , Myocardial Ischemia/etiology , Adult , Coronary Angiography , Coronary Disease/diagnosis , Exercise Test , Female , Humans , Male , Middle Aged , Myocardial Infarction/diagnosis , Myocardial Infarction/etiology , Myocardial Ischemia/diagnosis , Myocardial Ischemia/diagnostic imaging , UltrasonographyABSTRACT
Flunarizine, a calcium antagonist commonly employed in therapy for vascular diseases, enhances the in vitro and in vivo antitumor activity of vincristine on B16 melanoma cells. In the presence of flunarizine higher intracellular levels of vincristine were observed in vitro and for a longer time. B16 melanoma bearing mice treated with both the drugs presented a median survival time that was significantly longer than that of the controls. The possible mechanism of the enhancement is herein discussed.
