ABSTRACT
A four-month-old infant with severe impetigo who had prolonged daily applications of lindane presented with two seizure episodes. His blood lindane level was 1.27 ppm. Caution should be exercised when using lindane in infants and children. Proper instruction and close supervision are essential.
Subject(s)
Hexachlorocyclohexane/adverse effects , Seizures/chemically induced , Hexachlorocyclohexane/therapeutic use , Humans , Impetigo/drug therapy , Infant , MaleABSTRACT
Between October 1983 and May 1986, 17 cases of childhood acute lymphoblastic leukemia (ALL) were admitted to the General Hospital, Port of Spain, Trinidad. Fifteen of those cases were under 10 years of age, seven of whom presented with joint or bone pains. Boys outnumbered girls by almost 5:1 and the ethnic distribution showed a preponderance of patients of East Indian origin. At last follow-up (May 1989), the survival rate of the 15 under-10-year-old patients was 71%. Immunophenotype studies on nine of the 17 patients revealed six carrying T cell markers and three carrying markers suggestive of a pre-B phenotype. HLA tissue typing on 10 patients showed an enhanced frequency of the HLA-B40 antigen when compared with controls (p less than 0.05). This antigen was present in six of the patients typed and four carried the HLA-A2 and B40 antigens together, two of whom also carried the CW3 antigen and the other two carried untypable C antigens. Three of the four carrying HLA-A2 and B40 have died. Two of the three pre-B cases also carried the HLA-A2 and B40 antigens. HLA studies on three of the four families showed that HLA-A2 and B40 were on the same chromosome, i.e., a haplotype inherited from the mother in each case. None of the cases carried the HLA-B5 antigen although this antigen had a frequency of 37.8% in the control group (p less than 0.05). None of the controls with the HLA-B40 antigen carried the CW3 antigen. Further evidence of a disease association must await typing of the D locus antigens but current evidence would suggest an association between HLA-B40 and childhood ALL in Trinidad.
Subject(s)
Antigens, Differentiation/analysis , HLA Antigens/analysis , Precursor Cell Lymphoblastic Leukemia-Lymphoma/immunology , Child , Child, Preschool , Female , Follow-Up Studies , HLA-A2 Antigen/analysis , HLA-B Antigens/analysis , HLA-B40 Antigen , HLA-C Antigens/analysis , Humans , Infant , Male , Phenotype , Precursor Cell Lymphoblastic Leukemia-Lymphoma/ethnology , Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics , Trinidad and TobagoABSTRACT
This report describes two cases of Fanconi's anaemia in Trinidadian sisters of East Indian origin. The cases have been confirmed by chromosomal analysis which showed increased breaks and ring forms. Anorexia was a persistent finding in both cases. One of the sisters also had a poor growth hormone response.
Subject(s)
Anemia, Aplastic/genetics , Anorexia/complications , Child , Female , Humans , Trinidad and TobagoABSTRACT
This report describes two cases of Fanconi's in Trinidadian sisters of East Indian origin. The cases have been confirmed by chromosomal analysis which showed increased breaks and ring forms. Anorexia was a persistent finding in both cases. One of the sisters also had a poor growth hormone response
Subject(s)
Humans , Child, Preschool , Female , Anemia, Aplastic/etiology , Trinidad and Tobago , Anorexia/complicationsABSTRACT
We reported the isolation of Eikenella corrodens from a brain abscess in a child with cuanotic congenital heart disease in Trinidad
