[Hospital care for a child living with HIV in Dakar. What is the cost for the family?]. / Hospitalisation d'un enfant vivant avec le VIH à Dakar. Quel coût pour la famille ?

In sub-Saharan Africa, hospitalization is one of the main gateway for testing and care of children living with the HIV. The aim of this study is to estimate the direct costs of the hospitalization of children living with the HIV in Dakar (Senegal). The various expenses were collected daily with the medical file and by interview from the accompanying persons in 30 children. Median age was 9 years (1-17) with a sex ratio of 1.3. Siteen children were orphan and 7 died during the sur- vey. The median duration of the hospitaization was 20 days (3-71). Children older than 5 years had longer hospitalization duration than those under 5 years (p = 0.0001). The average full cost was 175,701 FCFA (268 €), distributed as follow: cost in the hospital 36%, cost of drugs 31%, cost of medical care 20% other non-medical expenses 13%. This survey explores an underdocumented aspect of HIV pediatric care : cost of hospitalization. It also addresses the issue of non-medical expenses resulting from the hospitalization, with regards to the families' income.

Anthropometric characteristics and cardiometabolic risk factors in a sample of urban-dwelling adults in Senegal.

AIM: The aim of this study was to analyze the relationship between anthropometric characteristics and cardiometabolic risk factors in urban-dwelling adults in Senegal to evaluate future threats to the public health in terms of chronic diseases. METHODS: Age- and gender-matched control subjects for a study on the prevalence of lipodystrophy in HIV+ patients were selected between June and September 2006 from the general population through systematic home visits guided by area of residence of cases. After consenting to participate, these subjects underwent anthropometric, clinical and biological examinations in their homes. RESULTS: The sample included 60 men and 106 women, mean age of 43.2 ± 9.4 years. Although the prevalence of overweight and obesity was much higher in women (30.2 and 29.2%, respectively) vs. 23.3 and 3.4%, respectively, in men (P<0.001), the women had lower waist-to-hip ratios (mean [95% CI]: 0.78 [0.77-0.80] vs. 0.86 [0.84-0.88] in men; P<10(-4)) and better systolic blood pressure, triglyceride and high-density lipoprotein (HDL)-cholesterol levels. However, their insulin levels were significantly higher (32.1 [28.2-36.5] pmol/l vs. 25.5 [21.0-30.8] in men; P<0.04). Principal component analysis showed that glucose and insulin correlated with subcutaneous fat, whereas blood pressure correlated with central fat distribution. Lipids were distributed between these two factors. CONCLUSION: Obesity still appears to be rare in Senegalese urban-dwelling men, whereas women, despite their overweight, have no untoward cardiometabolic profiles. However, the observed correlations between cardiometabolic risk factors and the amount and/or distribution of body fat suggest that obesity prevention should not be overlooked in the public health agenda for sub-Saharan Africa.

Amodiaquine dosage and tolerability for intermittent preventive treatment to prevent malaria in children.

Sulfadoxine-pyrimethamine with amodiaquine (SP-AQ) is a highly efficacious regimen for intermittent preventive treatment to prevent malaria in children (IPTc), but the amodiaquine component is not always well tolerated. We determined the association between amodiaquine dosage by body weight and mild adverse events (AEs) and investigated whether alternative age-based regimens could improve dosing accuracy and tolerability, using data from two trials of IPTc in Senegal, one in which AQ dose was determined by age and the other in which it was determined by weight category. Both dosage strategies resulted in some children receiving AQ doses above the recommended therapeutic range. The odds of vomiting increased with increasing amodiaquine dosage. In one study, incidence of fever also increased with increasing dosage. Anthropometric data from 1,956 children were used to predict the dosing accuracy of existing and optimal alternative regimens. Logistic regression models describing the probability of AEs by dosage were used to predict the potential reductions in mild AEs for each regimen. Simple amendments to current AQ dosing schedules based on the child's age could substantially increase dosing accuracy and thus improve the tolerability of IPTc using SP-amodiaquine in situations where weighing the child is impractical.

Physical activity patterns of rural Senegalese adolescent girls during the dry and rainy seasons measured by movement registration and direct observation methods.

OBJECTIVE: To study the physical activity patterns and daily estimates of energy expenditure (EE) of rural adolescent Senegalese girls. DESIGN: Physical activity was monitored using a portable accelerometer during four consecutive days and within the same time, by direct observation during two consecutive days. Adolescent girls were followed during the dry season (June, n = 40) and again during the rainy season (September, n = 30) SETTING: The Niakhar district in the central part of Senegal. SUBJECTS: Forty adolescents (13.3+/-0.5 y) drawn from a sample of 221 rural girls followed as part of a longitudinal study on growth and nutrition during puberty. RESULTS: Reliability of movement counts was acceptable (intraclass correlation, R = 0.71). There was a linear relationship between movement counts and observed scores. Predicted physical activity levels were high: 1.90+/-0.12 Mets (EE: 9.03+/-0.77 MJ). Physical activity levels derived from movement counts during the day are higher in the rainy season than during the dry season. This coincided with a depression in nutritional indicators during the rainy season apparent in the overall sample. Sleep duration appeared to be short in both seasons (6-6.5h per night). Senegalese adolescents participated in daily household tasks but time spent in productive activities, agricultural or handicraft, was less than 1 h per day. CONCLUSIONS: Estimates of activity-related EE of Senegalese adolescents were greater than those of adolescents from developed countries but closed to recent estimates for rural areas in developing countries. Energy requirements drawn from developed countries do not necessarily apply to African adolescent girls.