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Pharmacology ; 68(2): 89-95, 2003 Jun.
Article in English | MEDLINE | ID: mdl-12711836

ABSTRACT

One hundred and sixteen Latin American type 2 diabetic patients previously only on a diet were enrolled in this multicenter, multinational, nonrandomized, noncontrolled study. Only 109 completed the study. After 8 weeks of treatment with 120 mg of nateglinide, administered prior to each meal, the postprandial (2 h) glucose concentration decreased to 85.11 +/- 5.65 mg/dl (p < 0.0001), and HbA(1c) values decreased to 1.06 +/- 0.10% (p < 0.0001). No response differences were detected in relation to age, gender, or ethnicity, but we did encounter a better response in recently diagnosed patients (

Subject(s)
Cyclohexanes/therapeutic use , Diabetes Mellitus, Type 2/drug therapy , Hyperglycemia , Hypoglycemic Agents/therapeutic use , Phenylalanine/therapeutic use , Postprandial Period/drug effects , Blood Glucose/drug effects , Cyclohexanes/adverse effects , Female , Humans , Hyperglycemia/drug therapy , Hyperglycemia/etiology , Hypoglycemic Agents/adverse effects , Latin America , Male , Middle Aged , Nateglinide , Phenylalanine/adverse effects , Phenylalanine/analogs & derivatives , Treatment Outcome
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