ABSTRACT
Background: The Finnish Diabetes Risk Score (FINDRISC) is a tool to predict 10-year risk of type 2 diabetes mellitus (T2DM), and visceral adiposity is associated with higher cardio-metabolic risk. The objective of the study was to assess the relationship of epicardial adipose tissue (EAT) thickness with T2DM risk according to the FINDRISC tool. Methods: The study was conducted in Ciudad Bolívar, Venezuela, and included 55 subjects of whom 37 (67.3%) were women and 18 (32.7%) men with ages between 18 and 75 years. A record was made of weight, height, body mass index (BMI), waist circumference (WC), fasting glucose, baseline insulin, plasma lipids, Homeostasis Model Assessment-Insulin Resistance (HOMA-IR), and EAT thickness. The FINDRISC tool, with WC cut-off points modified for Latin America (LA-FINDRISC) was used. Results: BMI, WC, plasma insulin concentration, HOMA-IR index, and EAT thickness were higher (P < 0.0001) in the high-risk group compared to subjects in the low-moderate risk group according to the LA-FINDRISC. LA-FINDRISC was positively correlated with BMI (r = 0.513; P = 0.0001), WC (r = 0.524; P = 0.0001), fasting blood glucose (r = 0.396; P = 0.003); baseline plasma insulin (r = 0.483; P = 0.0001); HOMA-IR index (r = 0.545; P = .0.0001); and EAT thickness ( r = 0.702; P = 0.0001). The multivariate regression analysis showed that fasting blood glucose (P = 0.023) and EAT thickness (P = 0.007) remained independently associated with high T2DM risk. Conclusions: LA-FINDRISC was associated with EAT thickness and insulin resistance markers. Both were independently and directly associated with high risk for diabetes in the LA-FINDRISC category
Introducción: La escala Finlandesa de riesgo de diabetes (FINDRISC) es una herramienta para predecir el riesgo a 10 años de diabetes tipo 2 (DMT2). La adiposidad visceral se asocia con un alto riesgo cardiometabólico. El objetivo fue evaluar la relación del espesor del tejido adiposo epicárdico (TAE) y el riesgo de DMT2 calculado según FINDRISC. Métodos: Este estudio fue realizado en Ciudad Bolívar, Venezuela. Cincuenta y cinco sujetos; 37 mujeres (67,3%) y 18 hombres (32,7%) con edades entre 18 y 75 años fueron incluidos. Peso, talla, índice de masa corporal (IMC), circunferencia abdominal (CA), glucemia, insulina basal, lípidos plasmáticos, Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) y espesor del TAE fueron medidos. Se aplicó el FINDRISC con puntos de corte de CA modificados para Latinoamérica (LA-FINDRISC). Resultados: El IMC, CA, insulina, HOMA-IR y espesor del TAE fueron mayores (p < 0,0001) en el grupo de alto riesgo comparado con el grupo de bajo-moderado riesgo según LA-FINDRISC. Esta escala se correlacionó positivamente con el IMC (r = 0,513; p = 0,0001), CA (r = 0,524; p = 0,0001), glucemia en ayuna (r = 0,396; p = 0,003); insulina (r = 0,483; p = 0,0001); HOMA-IR (r = 0,545; p = 0,0001); y espesor del TAE (r = 0,702; p = 0,0001). El análisis de regresión multivariante mostró que la glucemia en ayuna (p = 0,023) y el espesor del TAE (p = 0.007) se asociaron independientemente con alto riesgo de DMT2. Conclusiones: LA-FINDRISC se asocia tanto con el espesor del TAE como con marcadores de resistencia a la insulina. Ambos se asociaron directa e independientemente con la categoría de alto riesgo de DMT2 según LA-FINDRISC
Subject(s)
Humans , Male , Female , Adolescent , Young Adult , Adult , Middle Aged , Aged , Adipose Tissue/metabolism , Adiposity/physiology , Glucose/metabolism , Diabetes Mellitus, Type 2/epidemiology , Pericardium/metabolism , Body Mass Index , Body Weight/physiology , Cross-Sectional Studies , Insulin/blood , Insulin Resistance/physiology , Regression Analysis , Risk Factors , Venezuela , Waist Circumference/physiologyABSTRACT
BACKGROUND: The Finnish Diabetes Risk Score (FINDRISC) is a tool to predict 10-year risk of type 2 diabetes mellitus (T2DM), and visceral adiposity is associated with higher cardio-metabolic risk. The objective of the study was to assess the relationship of epicardial adipose tissue (EAT) thickness with T2DM risk according to the FINDRISC tool. METHODS: The study was conducted in Ciudad Bolívar, Venezuela, and included 55 subjects of whom 37 (67.3%) were women and 18 (32.7%) men with ages between 18 and 75 years. A record was made of weight, height, body mass index (BMI), waist circumference (WC), fasting glucose, baseline insulin, plasma lipids, Homeostasis Model Assessment-Insulin Resistance (HOMA-IR), and EAT thickness. The FINDRISC tool, with WC cut-off points modified for Latin America (LA-FINDRISC) was used. RESULTS: BMI, WC, plasma insulin concentration, HOMA-IR index, and EAT thickness were higher (P<0.0001) in the high-risk group compared to subjects in the low-moderate risk group according to the LA-FINDRISC. LA-FINDRISC was positively correlated with BMI (r=0.513; P=0.0001), WC (r=0.524; P=0.0001), fasting blood glucose (r=0.396; P=0.003); baseline plasma insulin (r=0.483; P=0.0001); HOMA-IR index (r=0.545; P=.0.0001); and EAT thickness (r=0.702; P=0.0001). The multivariate regression analysis showed that fasting blood glucose (P=0.023) and EAT thickness (P=0.007) remained independently associated with high T2DM risk. CONCLUSIONS: LA-FINDRISC was associated with EAT thickness and insulin resistance markers. Both were independently and directly associated with high risk for diabetes in the LA-FINDRISC category.
