The Contribution of Static and Dynamic Factors to Recidivism Prediction for Black and White Youth Offenders.

Scholars have presented concerns about potential for racial bias in risk assessments as a result of the inclusion of static factors, such as criminal history in risk assessments. The purpose of this study was to examine the extent to which static factors add incremental validity to the dynamic factors in criminogenic risk assessments. This study examined the Youth Level of Service/Case Management Inventory (YLS/CMI) in a sample of 1,270 youth offenders from a medium-sized Midwestern county between June 2004 and November 2013. Logistic regression was used to determine the predictive validity of the YLS/CMI and the individual contribution of static and dynamic domains of the assessment. Results indicated that the static domain differentially predicted recidivism for Black and White youth. In particular, the static domain was a significant predictor of recidivism for White youth, but this was not the case for Black youth. The dynamic domain significantly predicted recidivism for both Black and White offenders, and static risk factors improved prediction of recidivism for White youth, but not for Black youth.

Assessing the Incremental Validity of Andrews and Bonta's "Moderate Four" Predictors of Recidivism Using a Diverse Sample of Offending and Truant Youth.

Bonta and Andrews suggest that there are eight factors that predict recidivism among offenders, which they call the "Central Eight." They split up the Central Eight into the "Big Four" and the "Moderate Four," with the Big Four hypothesized to be more strongly associated with recidivism than the Moderate Four. The purpose of this study was to assess the incremental validity of the Moderate Four relative to the Big Four as they are measured on the Youth Level of Service/Case Management Inventory (YLS/CMI). The sample comprised 2,436 youth between the ages of 9 and 18 ( M = 14.34) in the formal probation and truancy division from a juvenile county court in the Midwest. Recidivism was measured as a new petition filed against a youth in court within 2 years of a youth's initial offense. Results indicated that the Moderate Four predictors provided no incremental validity beyond the Big Four but did not reduce the predictive validity of the YLS/CMI.

5-Flurouracil disrupts nuclear export and nuclear pore permeability in a calcium dependent manner.

Regulation of nuclear transport is an essential component of apoptosis. As chemotherapy induced cell death progresses, nuclear transport and the nuclear pore complex (NPC) are slowly disrupted and dismantled. 5-Fluorouracil (5-FU) and the camptothecin derivatives irinotecan and topotecan, are linked to altered nuclear transport of specific proteins; however, their general effects on the NPC and transport during apoptosis have not been characterized. We demonstrate that 5-FU, but not topotecan, increases NPC permeability, and disrupts Ran-mediated nuclear transport before the disruption of the NPC. This increased permeability is dependent on increased cellular calcium, as the Ca2+ chelator BAPTA-AM, abolishes the effect. Furthermore, increased calcium alone was sufficient to disrupt the Ran gradient. Combination treatments of 5-FU with topotecan or irinotecan, similarly disrupted nuclear transport before disassembly of the NPC. In both single and combination treatments nuclear transport was disrupted before caspase 9 activation, indicating that 5-FU induces an early caspase-independent increase in NPC permeability and alteration of nuclear transport. Because Crm1-mediated nuclear export of tumor suppressors is linked to drug resistance we also examined the effect of 5-FU on the nuclear export of a specific target, topoisomerase. 5-FU treatment led to accumulation of topoisomerase in the nucleus and recovered the loss nuclear topoisomerase induced by irinotecan or topotecan, a known cause of drug resistance. Furthermore, 5-FU retains its ability to cause nuclear accumulation of p53 in the presence of irinotecan or topotecan. Our results reveal a new mechanism of action for these therapeutics during apoptosis, opening the door to other potential combination chemotherapies that employ 5-FU as a calcium mediated inhibitor of Crm1-induced nuclear export of tumor suppressors.

The role of parenting stress in young children's mental health functioning after exposure to family violence.

This study evaluates the associations of young children's exposure to family violence events, parenting stress, and children's mental health functioning. Caregivers provided data for 188 children ages 3 to 5 years attending Head Start programming. Caregivers reported 75% of children had experienced at least 1 type of trauma event, and 27% of children had experienced a family violence event. Child mental health functioning was significantly associated with family violence exposure after controlling for children's age, gender, household income, and other trauma exposure (ß = .14, p = .033). Stress in the parenting role partially mediated the relationship between family violence exposure and young children's mental health functioning (ß = .12, p = .015, 95% confidence interval [0.02, 0.21]). Interventions for young children exposed to family violence should address the needs of the child, as well as the caregiver while also building healthy parent-child relationships to facilitate positive outcomes in children faced with trauma.