1.
Emerg Infect Dis
; 12(2): 314-8, 2006 Feb.
Article
in English
| MEDLINE
| ID: mdl-16494762
ABSTRACT
Complete genome sequencing of 22 West Nile virus isolates suggested 2 independent introductions into Mexico. A previously identified mouse-attenuated glycosylation variant was introduced into southern Mexico through the southeastern United States, while a common US genotype appears to have been introduced incrementally into northern Mexico through the southwestern United States.
Subject(s)
West Nile Fever/epidemiology , West Nile virus/isolation & purification , Animals , Bird Diseases/epidemiology , Bird Diseases/virology , Birds/classification , Birds/virology , Crows/virology , Culex/virology , Horse Diseases/epidemiology , Horse Diseases/virology , Horses/virology , Humans , Mexico/epidemiology , Mice , Molecular Sequence Data , Sequence Analysis, DNA , United States , Virulence , West Nile Fever/virology , West Nile virus/classification , West Nile virus/genetics , West Nile virus/pathogenicity
2.
Emerg Infect Dis
; 10(12): 2221-4, 2004 Dec.
Article
in English
| MEDLINE
| ID: mdl-15663867
ABSTRACT
The complete genome sequence of a Mexican West Nile virus isolate, TM171-03, included 46 nucleotide (0.42%) and 4 amino acid (0.11%) differences from the NY99 prototype. Mouse virulence differences between plaque-purified variants of TM171-03 with mutations at the E protein glycosylation motif suggest the emergence of an attenuating mutation.
