Expression of MAP3K3 mRNA and its prognosis in human ovarian carcinoma / 临床与实验病理学杂志

Purpose To investigate the expression of mitogen-activated protein kinase kinase kinase 3 (MAP3K3) mRNA in ovarian carcinoma patients and to explore the correlation among its expression, clinicopathological features and prognosis. Methods The expression of MAP3K3 mRNA in ovarian carcinoma and fallopian tube tissues were detected by qRT-PCR, and the correlation between MAP3K3 mRNA expression and clinicopathological features was also analyzed. Whether MAP3K3 mRNA expression could be used as an independent predictor of prognosis for patients with ovarian carcinoma was further determined. Results The expression of MAP3K3 mRNA in ovarian carcinoma was significantly higher than that in fallopian tube tissues (P＜0.05). High expression of MAP3K3 mRNA was significantly correlated with FIGO stage and Challenge model of ovarian carcinoma (P＜0.05). Kaplan-Meier survival analysis showed that the disease-free survival time and overall survival time of patients with high MAP3K3 mRNA expression were shorter than those with low expression (34 months vs 52.2 months, P＜0.05.38.6 months vs 52.5 months, P＜0.05). Univariate analysis showed that high expression of MAP3K3 mRNA was a risk factor for poor prognosis of ovarian carcinoma patients (HR=4.198, 95％C/: 1.711 ～10.302, P＜0.05). Conclusion MAP3K3 mRNA is highly expressed in ovarian carcinoma tissues. Its high expression is associated with FIGO stage, Challenge model and poor prognosis of ovarian carcinoma, which may involve in the malignant transformation of ovarian carcinoma.

Surgical outcomes for unilateral superior oblique palsy in Chinese population: a retrospective study.

AIM: To evaluate the outcome after surgery for unilateral superior oblique (SO) palsy in Chinese. METHODS: The medical records of 39 patients that underwent surgery for unilateral SO palsy between January 2003 and December 2012 at Caritas Medical Centre, Hong Kong, were retrospectively reviewed. All surgeries were performed by a single surgeon. Pre-operative assessments for vertical deviation, cyclo-deviation, and Knapp's classification were obtained to determine the nature and degree of surgical correction. Vertical deviation was measured at 1wk; 1, 6mo and on last follow-up day post-operatively. Cyclo-deviation was measured on last follow-up day post-operatively. RESULTS: During the 10y period, 39 subjects were recruited. The most common etiology was congenital (94.9%). Knapp's Type III (66.7%) and Type I (12.8%) classifications were the most common subtypes. To treat SO palsy, the most common surgical procedures were: isolated inferior oblique (IO) anteriorization (41.0%), isolated IO myectomy (10.3%), and isolated IO recession (10.3%). At 3.5±2.1y post-operatively, the vertical deviation was significantly reduced (15.1±6.2 PD versus 0.5±1.4 PD, P<0.0001) without significant improvement in cyclo-deviation (P=0.5). Initial vertical deviation was correlated with cyclo-torsion (r=0.4, P=0.007). Those with over-correction had greater initial vertical deviation (19.4±7.2 PD versus 13.2±4.3 PD, P=0.003). After a single operation, 84.6% of subjects achieved a vertical deviation within ±3 PD. CONCLUSION: The majority of subjects achieved corrected vertical deviation after a single surgery although there was no improvement in cyclo-deviation. Those with over-correction of primary position deviation had greater preoperative vertical deviation and it may be related to simultaneous multiple muscle surgery.

Muir-Torre Syndrome in a Middle-Aged Chinese Patient with Sebaceous Carcinoma of the Eyelid.

Muir-Torre syndrome is a rare, autosomal dominant condition characterized by the presence of a skin tumor of sebaceous differentiation and visceral malignancies. We reviewed the case of a 46-year-old Chinese man who had a bleeding mass over the right upper eyelid. He had a history of colon cancer and a family history satisfying the Amsterdam criteria for hereditary non-polyposis colorectal cancer syndrome with germline mutation in the MutS homolog-2 gene. The eyelid lesion was excised completely and submitted for histopathologic examination which showed sebaceous carcinoma. Frozen section and conjunctival map biopsy showed no residual malignancy or local metastasis. Post-operative positron-emission tomography with combined computed tomography did not reveal any residual or visceral malignancy. He had no recurrence in the 32-month follow-up period. We should consider Muir-Torre syndrome in patients with sebaceous carcinoma, especially in the presence of personal and/or family history of visceral malignancies.

Primary 23-gauge transconjunctival sutureless vitrectomy for rhegmatogenous retinal detachment.

PURPOSE: To describe the results of primary 23-gauge transconjunctival sutureless vitrectomy for rhegmatogenous retinal detachment (RRD). METHODS: In a prospective case series, 24 eyes of 24 consecutive patients with RRD underwent primary 23-gauge transconjunctival pars plana vitrectomy with intraocular gas tamponade. Postoperative follow-up ranged from 6 months to 16 months. RESULTS: Fifteen eyes (62.5%) had multiple breaks. Seven eyes (29.2%) had inferior breaks. Other complications included giant tear in one eye, peripheral choroidal detachment in one eye, and concomitant macular holes in two eyes. The primary anatomical success rate was 91.7%. The mean postoperative visual acuity at postoperative month 3 improved from 20/41 to 20/25 (P = 0.111) and from 20/735 to 20/56 (P < 0.0001) in macula-on and macula-off cases, respectively. One patient (4.2%) had hypotony on postoperative day 1. No patients developed choroidal detachments. No sutures were used in any of the sclerotomy sites. Of the patients, 87.5% reported no or mild foreign body sensation, whereas 79.1% reported no or mild pain on the first postoperative day. CONCLUSIONS: Twenty-three-gauge transconjunctival sutureless vitrectomy appears to be a feasible option in treating RRD in selected cases, with the potential benefit of reducing postoperative ocular irritation.