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3.
Panminerva Med ; 18(11-12): 492-8, 1976.
Article in English | MEDLINE | ID: mdl-995414
4.
J Cell Physiol ; 85(2 Pt 1): 271-81, 1975 Apr.
Article in English | MEDLINE | ID: mdl-1168202

ABSTRACT

Observations on the pattern of nuclear incorporation of 3H-TdR in long term (8-day) and short term (3-day) 3T3 cultures with local cell densities between 0.2 times 10-4 and 6.2 times 10-4 cells/cm2 are reported. Contrary to a number of previous studies our observations indicate that density dependent inhibition is exhibited in relatively sparse cultures, commencing at 0.5 times 10-4 cells/cm2. Various possible mechanisms which could have caused the observed pattern of density-dependent regression in labelling index are discussed.


Subject(s)
Contact Inhibition , Fibroblasts/physiology , Animals , Autoradiography , Cell Line , Cell Nucleus/metabolism , Mice , Mice, Inbred Strains/embryology , Models, Biological , Regression Analysis , Thymidine/metabolism
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