Subject(s)
Asthma/drug therapy , Cortisone/analogs & derivatives , Prednisolone/analogs & derivatives , Prednisone/pharmacology , Adrenal Cortex/drug effects , Adrenal Cortex Function Tests , Adult , Aged , Bronchitis/drug therapy , Calcium/urine , Carbohydrate Metabolism , Cortisone/pharmacology , Cortisone/therapeutic use , Drug Combinations/pharmacology , Drug Combinations/therapeutic use , Humans , Male , Middle Aged , Potassium/urine , Prednisolone/pharmacology , Prednisolone/therapeutic use , Prednisone/therapeutic use , Sodium/urine , Time FactorsABSTRACT
Ventilatory capacity tests and standardized respiratory questionnaires were used in 1973 and in 1980 to measure the effect of mixed dust exposure in the asbestos cement industry on respiratory symptoms and lung function in 65 exposed workers and 30 controls (exposed to polyvinyl chloride but not to asbestos). Workers exposed to asbestos had 1) a higher prevalence of breathlessness and chest pain, and a higher incidence of breathlessness; 2) lower 1980 values of forced vital capacity (FVC) (0.27-0.83 liters) and forced expiratory volume in 1 sec (FEV1) (0.23-0.62 liters); and 3) a faster decline (nearly 40 ml/year) in FVC and FEV1 between 1973 and 1980. The FVC annual decrease was 52.5 ml in the subjects with more than 15 years since first asbestos exposure, whereas it was 24.3 ml in those with less than 15 years, suggesting a faster decline after 15 years of exposure. The effect of asbestos exposure and smoking habits was less than additive as regards pulmonary function.
