Epigenetic effects of folate and related B vitamins on brain health throughout life: Scientific substantiation and translation of the evidence for health improvement strategies.

Suboptimal status of folate and/or interrelated B vitamins (B12 , B6 and riboflavin) can perturb one-carbon metabolism and adversely affect brain development in early life and brain function in later life. Human studies show that maternal folate status during pregnancy is associated with cognitive development in the child, whilst optimal B vitamin status may help to prevent cognitive dysfunction in later life. The biological mechanisms explaining these relationships are not clear but may involve folate-related DNA methylation of epigenetically controlled genes related to brain development and function. A better understanding of the mechanisms linking these B vitamins and the epigenome with brain health at critical stages of the lifecycle is necessary to support evidence-based health improvement strategies. The EpiBrain project, a transnational collaboration involving partners in the United Kingdom, Canada and Spain, is investigating the nutrition-epigenome-brain relationship, particularly focussing on folate-related epigenetic effects in relation to brain health outcomes. We are conducting new epigenetics analysis on bio-banked samples from existing well-characterised cohorts and randomised trials conducted in pregnancy and later life. Dietary, nutrient biomarker and epigenetic data will be linked with brain outcomes in children and older adults. In addition, we will investigate the nutrition-epigenome-brain relationship in B vitamin intervention trial participants using magnetoencephalography, a state-of-the-art neuroimaging modality to assess neuronal functioning. The project outcomes will provide an improved understanding of the role of folate and related B vitamins in brain health, and the epigenetic mechanisms involved. The results are expected to provide scientific substantiation to support nutritional strategies for better brain health across the lifecycle.

Mental performance in 8-year-old children fed reduced protein content formula during the 1st year of life: safety analysis of a randomised clinical trial.

In humans, maximum brain development occurs between the third trimester of gestation and 2 years of life. Nutrition during these critical windows of rapid brain development might be essential for later cognitive functioning and behaviour. In the last few years, trends on protein recommendations during infancy and childhood have tended to be lower than that in the past. It remains to be demonstrated that lower protein intakes among healthy infants, a part of being able to reduce obesity risk, is safe in terms of mental performance achievement. Secondary analyses of the EU CHOP, a clinical trial in which infants from five European countries were randomised to be fed a higher or a lower protein content formula during the 1st year of life. Children were assessed at the age of 8 years with a neuropsychological battery of tests that included assessments of memory (visual and verbal), attention (visual, selective, focused and sustained), visual-perceptual integration, processing speed, visual-motor coordination, verbal fluency and comprehension, impulsivity/inhibition, flexibility/shifting, working memory, reasoning, visual-spatial skills and decision making. Internalising, externalising and total behaviour problems were assessed using the Child Behaviour Checklist 4-18. Adjusted analyses considering factors that could influence neurodevelopment, such as parental education level, maternal smoking, child's gestational age at birth and head circumference, showed no differences between feeding groups in any of the assessed neuropsychological domains and behaviour. In summary, herewith we report on the safety of lower protein content in infant formulae (closer to the content of human milk) according to long-term mental performance.

Parents' perceptions of their neonates and their relation to infant development.

BACKGROUND: Father and mother neonatal perceptions can alter the parents' behaviour towards their child and influence their relationship and, consequently, his/her development. The aim of this study was to examine how mother-father perceptions of their neonates evolve during the first month of life, and whether these perceptions, and the psychological and social characteristics of the mothers are good predictors of infant development. METHODS: Seventy-two mother-father-child triads participated. Maternal personality, including neuroticism, and maternal depression and anxiety symptoms were assessed. Parents' neonatal perceptions and neonatal behaviour were assessed at 3 days and at 1 month post partum and infant development at 4 and 12 months post partum. RESULTS: Parents' initial perceptions were positive, decreased in both parents during the first month and evolved differently according to the child's gender. High maternal neuroticism was related to worse neonatal perceptions, and high father perception was related to better infant development at 12 months. CONCLUSIONS: These results support the contribution of parents' neonatal perception on infant development and may have social implications regarding the role of fathers in the parenting of their children.

[Symptoms of depression during puberty: initial results of a longitudinal epidemiological study]. / Síntomas de depresión en la etapa puberal: primeros resultados de un estudio epidemiológico longitudinal.

We present the results of a study on the depressive symptomatology in scholars during 2 years period of follow up. The initial sample was of 534 subjects (223 girls and 311 boys) of 11 and 12 years. We performed the evaluation of depressive symptoms with the self-evaluative scale CDI. We examined the puberal development with the Tanner stages. The prevalence of depressive symptoms was high and did not differ as a whole in the 2 years of survey (9.4% and 9.7%). Results showed an increment in the feminine sex from puberal stage. The incidence of depressive symptomatology in a 1 year period is 6.2%. We observed a different clinical expressivity between boys and girls. There was no significant relation between puberal stages and depressive symptoms. The results obtained support the concept of chronicity of depressive syndrome, at the same time as suggest that puberty is a crucial stage in the prevention itself.