1.
Farmaco Sci
; 40(10): 755-69, 1985 Oct.
Article
in English
| MEDLINE
| ID: mdl-4085640
ABSTRACT
Grosheimia macrocephala (Compositae) proved to be a very interesting natural source, not only of grosheimin (I), but also of cynaropicrin (III). Some derivatives from these two natural sesquiterpene gamma-lactones were prepared (Schemes 2 and 3) and two new natural guaianolides: 4'-deoxy-cynaropicrin (V) and 4'-nor-2'-metoxy-cynaropicrin (VI) were isolated and structurally identified. A series of these compounds were submitted to in vitro preliminary testing of cytostatic activity against KB cell lines and relationships between bioactivity and chemical features were investigated.