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Bioorg Med Chem Lett
; 12(7): 1063-6, 2002 Apr 08.
Article
in English
| MEDLINE
| ID: mdl-11909718
ABSTRACT
We have synthesized and evaluated a series of tetramic acid-based and hydroxyquinolinone-based inhibitors of plasminogen activator inhibitor-1 (PAI-1). These studies resulted in the identification of several compounds which showed excellent potency against PAI-1. The design, synthesis and SAR of these compounds are described.