Subject(s)
Humans , Female , Aged , Unilateral Breast Neoplasms , Prostheses and Implants , Pectoralis Muscles , Lung , Post Disaster Reconstruction , Sternum , RibsABSTRACT
OBJECTIVES: This analysis aimed to evaluate perioperative outcomes of surgical resection following neoadjuvant treatment with chemotherapy plus nivolumab in resectable stage IIIA non-small-cell lung cancer. METHODS: Eligible patients received neoadjuvant chemotherapy (paclitaxel + carboplatin) plus nivolumab for 3 cycles. Reassessment of the tumour was carried out after treatment and patients with at least stable disease as best response underwent pulmonary resection. After surgery, patients received adjuvant treatment with nivolumab for 1 year. Surgical data were collected from the NADIM database and patient charts were reviewed for additional surgical details. RESULTS: Among 46 patients who received neoadjuvant treatment, 41 (89.1%) underwent surgery. Two patients rejected surgery and 3 did not fulfil resectability criteria. There were 35 lobectomies (85.3%), 3 of which were sleeve lobectomies (9.4%), 3 bilobectomies (7.3%) and 3 pneumonectomies (7.3%). Video-assisted thoracoscopy was the initial approach in 51.2% of cases, with a conversion rate of 19% (n = 4). There was no operative mortality at either 30 or 90 days. The most common complications were prolonged air leak (n = 8), pneumonia (n = 5) and arrhythmia (n = 4). Complete resection (R0) was achieved in all patients who underwent surgery, downstaging was observed in 37 patients (90.2%) and major pathological response in 34 patients (82.9%). CONCLUSIONS: Surgical resection following induction therapy with chemotherapy plus nivolumab appears to be safe and offers appropriate oncological outcomes. Perioperative morbidity and mortality rates in our study were no higher than previously reported in this setting. A minimally invasive approach is, therefore, feasible.
Subject(s)
Carcinoma, Non-Small-Cell Lung , Lung Neoplasms , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Carcinoma, Non-Small-Cell Lung/drug therapy , Carcinoma, Non-Small-Cell Lung/surgery , Humans , Lung Neoplasms/drug therapy , Lung Neoplasms/surgery , Neoadjuvant Therapy , Neoplasm Staging , Pneumonectomy , Treatment OutcomeABSTRACT
No disponible
Subject(s)
Humans , Male , Aged , Bronchodilator Agents/administration & dosage , Respiratory Aspiration/complications , Foreign-Body Migration/surgery , Administration, InhalationSubject(s)
Metered Dose Inhalers , Nebulizers and Vaporizers , Administration, Inhalation , Asthma , Foreign Bodies , HumansABSTRACT
No disponible
Subject(s)
Humans , Female , Aged, 80 and over , Thoracic Surgical Procedures/classification , Thoracic Surgical Procedures/methods , Thoracic Surgical Procedures/trends , Prostheses and Implants/classification , Thoracic Wall/injuries , Prostheses and Implants/trends , Prostheses and ImplantsABSTRACT
No disponible
Subject(s)
Humans , Male , Middle Aged , Hernia, Abdominal/etiology , Thoracic Injuries/complications , Thoracotomy/methods , Obesity/complicationsSubject(s)
Hernia/etiology , Herniorrhaphy , Thoracic Injuries/complications , Thoracic Injuries/surgery , Hernia, Abdominal , Humans , Male , Middle AgedABSTRACT
No disponible
No disponible
Subject(s)
Humans , Female , Adolescent , Carcinoma, Papillary/surgery , Lymph Node Excision/methods , Neoplasm Recurrence, Local/surgery , Thyroid Neoplasms/surgery , Mediastinum , NeckSubject(s)
Ganglioneuroma/diagnosis , Liver Neoplasms/secondary , Liver Neoplasms/surgery , Lung Neoplasms/secondary , Lung Neoplasms/surgery , Mediastinal Neoplasms/diagnosis , Neoplasms, Germ Cell and Embryonal/secondary , Neoplasms, Germ Cell and Embryonal/surgery , Neoplasms, Multiple Primary/diagnosis , Testicular Neoplasms/pathology , Adolescent , Humans , Incidental Findings , Intraoperative Period , MaleABSTRACT
No disponible
Subject(s)
Humans , Male , Adolescent , Ganglioneuroma/diagnosis , Ganglioneuroma/surgery , Mediastinal Neoplasms/diagnosis , Mediastinal Neoplasms/surgery , Liver Neoplasms/surgery , Lung Neoplasms/surgery , Incidental Findings , Tomography, X-Ray ComputedSubject(s)
Bronchial Neoplasms/surgery , Carcinoid Tumor/surgery , Biopsy , Bronchi/pathology , Bronchial Neoplasms/diagnostic imaging , Bronchial Neoplasms/pathology , Bronchoscopy , Carcinoid Tumor/diagnostic imaging , Carcinoid Tumor/pathology , Child , Female , Humans , Pneumonectomy , Radiography, Thoracic , Tomography, X-Ray ComputedABSTRACT
No disponible
