1.
J Org Chem
; 73(19): 7657-62, 2008 Oct 03.
Article
in English
| MEDLINE
| ID: mdl-18781804
ABSTRACT
A new and versatile synthetic route to Securinega alkaloids is reported. The first synthesis of allosecurinine has been accomplished in seven steps and 40% yield, starting from (+)-menisdaurilide, using a vinylogous Mannich reaction as the key transformation. Similarly, viroallosecurinine has been synthesized from (-)-menisdaurilide.