ABSTRACT
OBJECTIVE: To study the preparation technology and physicochemical characterization of curcumin loaded gelatin microspheres for lung targeting. METHODS: Curcumin loaded gelatin microspheres for lung targeting were prepared by the emulsion crosslinking method, and the preparation technology was optimized by orthogonal experimental design with biodegradable gelatin as the carrier, liquid paraffin as the oil phase, span 80 as the emulsifier. RESULTS: The optimal curcumin loaded gelatin microspheres were global with smooth surface, 6.15% for the drug loading, 75.5% for the encapsulation efficiency. 86.6% of microspheres size was in the range of 5-30 microm. The release test in vitro showed that 50% of curcumin could release from gelatin microspheres in 22 h and 77% in 48 h. CONCLUSIONS: The preparation technology is good and stable, and the obtained microspheres can control the release of curcumin.
