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1.
Spectrochim Acta A Mol Biomol Spectrosc ; 319: 124490, 2024 Oct 15.
Article in English | MEDLINE | ID: mdl-38820816

ABSTRACT

Chiral enantiomers have significant differences in biochemical functions. The use of THz wave polarization detection to characterize the optical properties of chiral substances is of great significance to the development of life science and the identification and application of chiral substances. However, the traditional polarization detection procedures of THz waves are complex, which limits the study of chiral substances. Herein, we proposed a high-sensitivity THz polarization detector, which can simultaneously obtain the change information of amplitude, phase, and polarization state through a single measurement. The optical rotation and elliptical angle of solid and liquid D/L-Glutamic acid 5-methyl ester in the THz band are studied. Then it is verified that anisotropic interference may occur in the preparation of solid samples. Finally, the effects of sample content and thickness on polarization are obtained. The experimental results show that different chirality has the opposite effect on the state of polarization, and the difference between chiral enantiomers can be detected by this method. This work is of great significance for understanding the optical properties of chiral substances and promoting the development of chiral recognition.

2.
Front Bioeng Biotechnol ; 11: 1170218, 2023.
Article in English | MEDLINE | ID: mdl-37034259

ABSTRACT

Terahertz (THz) technology has emerged as a promising tool for the qualitative and quantitative identification of markers containing major diseases, enabling early diagnosis and staged treatment of diseases. Nevertheless, the detection of water-containing biological samples is facing significant challenges due to limitations in high-power THz radiation sources and high-sensitivity detection devices. In this paper, we present a designed and constructed set of Terahertz-Attenuated Total Reflection (THz-ATR) spectrometer for high-sensitivity detection of liquid biological samples, which can dynamically maintain the signal-to-noise ratio (SNR) of THz detection signal of liquid biological samples at 40-60 dB. Our high-power THz-ATR spectroscopy can identify and quantitatively detect α-lactose aqueous solution with a minimum concentration of 0.292 mol/L. Moreover, we observed that the rate of change in the absorption peak position varied greatly between high and low concentration samples. Our high-power, high-sensitivity THz-ATR spectroscopy detection provides a rapid, accurate, and low-cost method for detecting disease markers such as blood and urine indicators. Additionally, this approach offers new perspectives for the refinement and in-depth detection of biomedical samples.

3.
Spectrochim Acta A Mol Biomol Spectrosc ; 287(Pt 2): 122075, 2023 Feb 15.
Article in English | MEDLINE | ID: mdl-36356399

ABSTRACT

The rapid and accurate identification of the types and contents of early pathological markers by THz technology are of particular importance for the prevention and treatment of major diseases. Nevertheless, these markers usually contain interference from water and other non-target molecules, resulting in low signal-to-noise ratio (SNR) and making identification and quantitative analysis difficult. Here, based on THz spectroscopy from a high-power THz source radiated by LiNbO3, we perform quantitative and real-time THz detection of mixtures (α-lactose monohydrate and 4-aminobenzoic acid) in liquids. The results demonstrate that the absorption spectra of the aqueous biomolecular mixtures exhibit an accumulation of THz features of each pure product, i.e., the amplitude of the absorption peaks is proportional to the mixing ratio, while the corresponding absorption baseline increases with decreasing concentration. Furthermore, the content of the target substance can be calculated from the linear relationship between the absorption spectra of pure and mixed samples. This technology will support the future application of THz-TDS in early disease diagnosis under complex states and environments.


Subject(s)
Terahertz Spectroscopy , Terahertz Spectroscopy/methods , Spectrum Analysis/methods , Water
4.
iScience ; 25(7): 104637, 2022 Jul 15.
Article in English | MEDLINE | ID: mdl-35800762

ABSTRACT

We demonstrate the successful implementation of a terahertz (THz) quantum-well photodetector (QWP) for effective signal collection in a scattering-type scanning near-field optical microscope (s-SNOM) system. The light source is an electrically pumped THz quantum cascade laser (QCL) at 4.2 THz, which spectrally matches with the peak photoresponse of THz QWP. The sensitive THz QWP has a low noise equivalent power (NEP) of about 1.1 pW/Hz0.5 and a spectral response range from 2 to 7 THz. The fast-responding capability of the THz QWP is vital for detecting the rapidly tip-modulated THz light which can effectively suppress the background noise. The THz images of the nanostructure demonstrate a spatial resolution of about 95 nm, corresponding to ∼λ/752 at 4.2 THz. We experimentally investigate and theoretically interpret the formation of the fringes which appear at the edge position of a gold stripe in the THz near-field image.

5.
Opt Lett ; 47(12): 3115-3118, 2022 Jun 15.
Article in English | MEDLINE | ID: mdl-35709064

ABSTRACT

Terahertz waves are electromagnetic waves located at 0.1-10 THz, and terahertz imaging technology can be applied to security inspection, biomedicine, non-destructive testing of materials, and other fields. At present, terahertz images have unclear data and rough edges. Therefore, improving the resolution of terahertz images is one of the current hot research topics. This paper proposes an efficient terahertz image super-resolution model, which is used to extract low-resolution (LR) image features and learn the mapping of LR images to high-resolution (HR) images, and then introduce an attention mechanism to let the network pay attention to more information features. Finally, we use sub-pixel convolution to learn a set of scaling filters to upgrade the final LR feature map to an HR output, which not only reduces the model complexity, but also improves the quality of the terahertz image. The resolution reaches 31.67 db on the peak signal-to-noise ratio (PSNR) index and 0.86 on the structural similarity (SSIM) index. Experiments show that the efficient sub-pixel convolutional neural network used in this article achieves better accuracy and visual improvement compared with other terahertz image super-resolution algorithms.

6.
Sci Adv ; 8(21): eabn2031, 2022 May 27.
Article in English | MEDLINE | ID: mdl-35613269

ABSTRACT

High-performance broadband infrared (IR)/terahertz (THz) detection is crucial in many optoelectronic applications. However, the spectral response range of semiconductor-based photodetectors is limited by the bandgaps. This paper proposes a ratchet structure based on the GaAs/AlxGa1-xAs heterojunction, where the quasi-stationary hot hole distribution and intravalence band absorption from light or heavy hole states to the split-off band overcome the bandgap limit, ensuring an ultrabroadband photoresponse from near-IR to THz region (4 to 300 THz). The peak responsivity of the proposed structure can reach 7.3 A/W, which is five orders of magnitude higher than that of the existing broadband photon-type detector. Because of the ratchet effect, the proposed photodetector has a bias-tunable photoresponse characteristic and can operate in the photovoltaic mode with a broad photocurrent spectrum (18 to 300 THz). This work not only demonstrates a broadband photon-type THz/IR photodetector but also provides a method to study the light-responsive ratchet.

7.
Nanomaterials (Basel) ; 12(7)2022 Mar 28.
Article in English | MEDLINE | ID: mdl-35407230

ABSTRACT

We propose a terahertz frequency multiplier based on high order harmonic generation in a GaAs-based miniband superlattice driven by an electric field. The performance of the frequency multiplier is analyzed using the balance equation approach, which incorporates momentum and energy relaxation processes at different lattice temperatures. It is found that the generated high-order harmonic power is sensitive to temperature changes. The peak power appears around resonance between driving terahertz frequency and intrinsic Bloch frequency. In the presence of the magnetic field, the peak power shifts towards a stronger static electric field region. The simulated results about the dependence of the second and third harmonic powers on a DC electric field are in qualitative consistence with the experiments. The proposed terahertz frequency multiplier based on semiconductor superlattice, being compact and efficient, is provided as a good candidate for terahertz wave generation.

8.
iScience ; 24(11): 103316, 2021 Nov 19.
Article in English | MEDLINE | ID: mdl-34778731

ABSTRACT

Terahertz (THz) technology lays the foundation for next-generation high-speed wireless communication, nondestructive testing, food safety inspecting, and medical applications. When THz technology is integrated by artificial intelligence (AI), it is confidently expected that THz technology could be accelerated from the laboratory research stage to practical industrial applications. Employing THz video imaging, we can gain more insights into the internal morphology of silkworm egg. Deep learning algorithm combined with THz silkworm egg images, rapid recognition of the silkworm egg development stages is successfully demonstrated, with a recognition accuracy of ∼98.5%. Through the fusion of optical imaging and THz imaging, we further improve the AI recognition accuracy of silkworm egg development stages to ∼99.2%. The proposed THz imaging technology not only features the intrinsic THz imaging advantages, but also possesses AI merits of low time consuming and high recognition accuracy, which can be extended to other application scenarios.

9.
Nanomaterials (Basel) ; 11(2)2021 Feb 07.
Article in English | MEDLINE | ID: mdl-33562303

ABSTRACT

Terahertz reflection behaviors of metallic-grating-dielectric-metal (MGDM) microcavity with a monolayer graphene embedded into the dielectric layer are theoretically investigated. A tunable wideband reflection dip at about the Fabry-Pérot resonant frequency of the structure is found. The reflectance at the dip frequency can be electrically tuned in the range of 96.5% and 8.8%. Because of the subwavelength distance between the metallic grating and the monolayer graphene, both of the evanescent grating slit waveguide modes and the evanescent Rayleigh modes play key roles in the strong absorption by the graphene layer. The dependence of reflection behaviors on the carrier scattering rate of graphene is analyzed. A prototype MGDM-graphene structure is fabricated to verify the theoretical analysis. Our investigations are helpful for the developments of electrically controlled terahertz modulators, switches, and reconfigurable antennas based on the MGDM-graphene structures.

10.
Front Optoelectron ; 14(1): 94-98, 2021 Mar.
Article in English | MEDLINE | ID: mdl-36637779

ABSTRACT

In this paper, we presented single mode terahertz quantum cascade lasers (THz QCLs) with sampled lateral grating emitting approximately 3.4 THz. Due to strong mode selection, the implementation of sampled lateral grating on THz QCL ridges can result in stable single longitudinal mode emission with a side-mode suppression ratio larger than 20 dB. The measured peak power of the grating laser is improved by about 11.8% compared to the power of devices with uniform distributed feedback gratings. Furthermore, the far-field pattern of the presented device is uninfluenced by grating structures.

11.
Small ; 16(17): e2000294, 2020 04.
Article in English | MEDLINE | ID: mdl-32162840

ABSTRACT

Metamaterial (MM) sensors and devices, usually consisting of artificially structured composite materials with engineered responses that are mainly determined by the unit structure rather than the bulk properties or composition, offer new functionalities not readily available in nature. A set of implantable and resorbable therapeutic MM devices at terahertz (THz) frequencies are designed and fabricated by patterning magnesium split ring resonators on drug-loaded silk protein substrates with controllable device degradation and drug release rates. To demonstrate proof-of-concept, a set of silk-based, antibiotics-loaded MM devices, which can serve as degradable antibacterial skin patches with capabilities to monitor drug-release in real time are fabricated. The extent of drug release, which correlates with the degradation of the MM skin patch, can be monitored by analyzing the resonant responses in reflection during degradation using a portable THz camera. Animal experiments are performed to demonstrate the in vivo degradation process and the efficacy of the devices for antibacterial treatment. Thus, the implantable and resorbable therapeutic MM devices do not need to be retrieved once implanted, providing an appealing alternative for in-vivo sensing and in situ treatment applications.


Subject(s)
Anti-Bacterial Agents , Biocompatible Materials , Infusion Pumps, Implantable , Prostheses and Implants , Silk , Animals , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/pharmacology , Biocompatible Materials/administration & dosage , Biocompatible Materials/chemistry , Biocompatible Materials/metabolism , Rats , Rats, Sprague-Dawley , Silk/chemistry , Staphylococcal Infections/drug therapy , Staphylococcus aureus/drug effects , Wounds and Injuries/drug therapy
12.
Adv Sci (Weinh) ; 6(20): 1900460, 2019 Oct 16.
Article in English | MEDLINE | ID: mdl-31637156

ABSTRACT

Optical frequency combs, consisting of well-controlled equidistant frequency lines, have been widely used in precision spectroscopy and metrology. Terahertz combs have been realized in quantum cascade lasers (QCLs) by employing either an active mode-locking or phase seeding technique, or a dispersion compensator mirror. However, it remains a challenge to achieve the passive comb formation in terahertz semiconductor lasers due to the insufficient nonlinearities of conventional saturable absorbers. Here, a passive terahertz frequency comb is demonstrated by coupling a multilayer graphene sample into a QCL compound cavity. The terahertz modes are self-stabilized with intermode beat note linewidths down to a record of 700 Hz and the comb operation of graphene-coupled QCLs is validated by on-chip dual-comb measurements. Furthermore, the optical pulse emitted from the graphene-coupled QCL is directly measured employing a terahertz pump-probe technique. The enhanced passive frequency comb operation is attributed to the saturable absorption behavior of the graphene-integrated saturable absorber mirror, as well as the dispersion compensation introduced by the graphene sample. The results provide a conceptually different graphene-based approach for passive comb formation in terahertz QCLs, opening up intriguing opportunities for fast and high-precision terahertz spectroscopy and nonlinear photonics.

13.
Nat Commun ; 10(1): 3513, 2019 08 05.
Article in English | MEDLINE | ID: mdl-31383862

ABSTRACT

High performance terahertz imaging devices have drawn wide attention due to their significant application in healthcare, security of food and medicine, and nondestructive inspection, as well as national security applications. Here we demonstrate a broadband terahertz photon-type up-conversion imaging device, operating around the liquid helium temperature, based on the gallium arsenide homojunction interfacial workfunction internal photoemission (HIWIP)-detector-LED up-converter and silicon CCD. Such an imaging device achieves broadband response in 4.2-20 THz and can absorb the normal incident light. The peak responsivity is 0.5 AW-1. The light emitting diode leads to a 72.5% external quantum efficiency improvement compared with the one widely used in conventional up-conversion devices. A peak up-conversion efficiency of 1.14 × 10-2 is realized and the optimal noise equivalent power is 29.1 pWHz-1/2. The up-conversion imaging for a 1000 K blackbody pin-hole is demonstrated. This work provides a different imaging scheme in the terahertz band.

14.
Sci Rep ; 9(1): 6700, 2019 Apr 30.
Article in English | MEDLINE | ID: mdl-31040391

ABSTRACT

Stabilization issue of anomalous refraction and reflection in V-shaped antenna metasurfaces are investigated. Specifically, when a V-shaped metasurface is artificially tilted, the induced refraction and reflection are theoretically analyzed. Detailed numerical and experimental study is then performed for the upward and downward bending metasurfaces. Our results show that although the anomalous reflection is sensitive to the deformation of metasurface geometry; the anomalous refraction is, surprisingly, barely affected by relatively small-angle tilting and able to support perfect beam orienting. Since in real-world applications, the optical objects are often affected by multiple uncertain factors, such as deformation, vibration, non-standard surface, non-perfect planar, etc., the stabilization of optical functionality has therefore been a long-standing design challenge for optical engineering. We believe our findings can shed new light on this stability issue.

15.
Adv Sci (Weinh) ; 5(7): 1700982, 2018 Jul.
Article in English | MEDLINE | ID: mdl-30027034

ABSTRACT

Recent progress in ultrafast spectroscopy and semiconductor technology is enabling unique applications in screening, detection, and diagnostics in the Terahertz (T-ray) regime. The promise of efficaciously operation in this spectral region is tempered by the lack of devices that can spectrally analyze samples at sufficient temporal and spatial resolution. Real-time, multispectral T-ray (Mul-T) imaging is reported by designing and demonstrating hyperspectral metamaterial focal plane array (MM-FPA) interfaces allowing multiband (and individually tunable) responses without compromising on the pixel size. These MM-FPAs are fully compatible with existing microfabrication technologies and have low noise when operating in the ambient environment. When tested with a set of frequency switchable quantum cascade lasers (QCLs) for multicolor illumination, both MM-FPAs and QCLs can be tuned to operate at multiple discrete THz frequencies to match analyte "fingerprints." Versatile imaging capabilities are presented, including unambiguous identification of concealed substances with intrinsic and/or human-engineered THz characteristics as well as effective diagnosis of cancerous tissues without notable spectral signatures in the THz range, underscoring the utility of applying multispectral approaches in this compelling wavelength range for sensing/identification and medical imaging.

16.
Opt Express ; 26(25): 32675-32690, 2018 Dec 10.
Article in English | MEDLINE | ID: mdl-30645430

ABSTRACT

The radio frequency (RF) modulation is a powerful tool, which is used for generating sidebands in semiconductor lasers for active mode-locking. The two-section coupled-cavity laser geometry shows advantages over traditional Fabry-Pérot cavities in the RF modulation efficiency, because of its reduced device capacitance of short section cavity. Further, it has been widely used for active/passive mode-locking of semiconductor diode lasers. For semiconductor-based quantum cascade lasers (QCLs) emitting in the far-infrared or terahertz frequency bands, the two-section coupled-cavity configuration can strongly prevent the laser from multimode emissions. This is because of its strong mode selection (loss modulation), which the cavity geometry introduces. Here, we experimentally demonstrate that the coupled-cavity terahertz QCL can be actively modulated to generate sidebands. The RF modulation is efficient at the frequency that equals the difference frequency between the fundamental and higher order transverse modes of the laser, and its harmonics. We show for the first time that, when the laser is modulated at the second harmonic of the difference frequency, the sideband generation in coupled-cavity terahertz QCLs and the generated sidebands are equally spaced by the injected microwave frequency. Our results, which are presented here, provide a novel approach for modulating terahertz coupled-cavity lasers for active mode-locking. The coupled-cavity geometry shows advantages in generating dense modes with short cavities for potential high-resolution spectroscopy. Furthermore, the short coupled-cavity laser consumes less electrical power than Fabry-Pérot lasers that generate a similar mode spacing.

17.
Sci Rep ; 7(1): 3452, 2017 06 14.
Article in English | MEDLINE | ID: mdl-28615654

ABSTRACT

The fast detection of terahertz radiation is of great importance for various applications such as fast imaging, high speed communications, and spectroscopy. Most commercial products capable of sensitively responding the terahertz radiation are thermal detectors, i.e., pyroelectric sensors and bolometers. This class of terahertz detectors is normally characterized by low modulation frequency (dozens or hundreds of Hz). Here we demonstrate the first fast semiconductor-based terahertz quantum well photodetectors by carefully designing the device structure and microwave transmission line for high frequency signal extraction. Modulation response bandwidth of gigahertz level is obtained. As an example, the 6.2-GHz modulated terahertz light emitted from a Fabry-Pérot terahertz quantum cascade laser is successfully detected using the fast terahertz quantum well photodetector. In addition to the fast terahertz detection, the technique presented in this work can also be used for optically characterizing the frequency stability of terahertz quantum cascade lasers, heterodyne detections and photomixing applications.

18.
Appl Spectrosc ; 71(2): 194-202, 2017 Feb.
Article in English | MEDLINE | ID: mdl-27815434

ABSTRACT

Terahertz time-domain spectroscopy (THz-TDS) is used to investigate the absorption spectra of polycrystalline L- and DL-histidine in the frequency range of 10-100 cm-1. The spectra exhibit distinct differences in peak frequencies between the enantiomer (L-histidine) and racemic compound (DL-histidine). The observed spectral differences are attributed to the intermolecular interactions. With the density function theory (DFT) method, the frequencies of vibrational modes of L-histidine and DL-histidine in the THz range are calculated and well assigned according to the measured spectra. The origin of the observed vibrational modes is found to be non-localized and of a collective (phonon-like) nature, which points to the lattice and skeleton vibrations mediated by the hydrogen bond. Furthermore, we propose and demonstrate a method for determining the composition ratio of histidine mixtures based on the THz absorption spectra.

19.
Nanoscale Res Lett ; 10: 26, 2015.
Article in English | MEDLINE | ID: mdl-25852323

ABSTRACT

The dynamical regimes and performance optimization of quantum dot monolithic passively mode-locked lasers with extremely low repetition rate are investigated using the numerical method. A modified multisection delayed differential equation model is proposed to accomplish simulations of both two-section and three-section passively mode-locked lasers with long cavity. According to the numerical simulations, it is shown that fundamental and harmonic mode-locking regimes can be multistable over a wide current range. These dynamic regimes are studied, and the reasons for their existence are explained. In addition, we demonstrate that fundamental pulses with higher peak power can be achieved when the laser is designed to work in a region with smaller differential gain.

20.
Opt Express ; 18(8): 7782-9, 2010 Apr 12.
Article in English | MEDLINE | ID: mdl-20588619

ABSTRACT

Numerical method on the heterodyne terahertz detection characteristics of field effect characteristics of field effect transistors is studied in this paper which is based on the hydrodynamic equations which govern the terahertz signal transport in field effect transistors (FETs). A modification is made in an existed numerical tool established by our group by coupling the heterodyne characteristics. This modified numerical tool work well in all operation regions of FETs from sub-threshold to strong inversion and from linear to saturation. And the results are used to demonstrate the potential for using MOS transistors as THz detectors and investigate the optimization of the device structure.

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