ABSTRACT
OBJECTIVE: To study the effect of O/W Microemulsion in enhancing solubility of baicalin and puerarin. METHOD: The Pseudo-ternary phase diagram was employed to selected the formulations of O/W microemulsion. The partical size of microemulsion, and solubility of baicalin and puerarin in water, oil phase, surfactant, microemulsion and alcohol were determined, respectively. RESULT: 11 types of microemulsion formulations have the effect in enhancing the solubility of baicalin and puerarin; the solubility of Baicalin in microemulsion is higher as 5-15 times than it in water, the solubility of Puerarin in microemulsion is higher as 3 - 4 times than it in water. CONCLUSION: Microemulsion is good in enhancing solubility of effective compounds extracted from Chinese medical herbs.
