ABSTRACT
Helicobacter pylori has been widely recognized as an important human pathogen responsible for chronic gastritis, peptic ulcers, gastric cancer, and mucosa-associated lymphoid tissue (MALT) lymphoma. Little is known about the natural history of this infection since patients are usually recognized as having the infection only after years or decades of chronic disease. Several animal models of H. pylori infection, including those with different species of rodents, nonhuman primates, and germ-free animals, have been developed. Here we describe a new animal model in which the clinical, pathological, microbiological, and immunological aspects of human acute and chronic infection are mimicked and which allows us to monitor these aspects of infection within the same individuals. Conventional Beagle dogs were infected orally with a mouse-adapted strain of H. pylori and monitored for up to 24 weeks. Acute infection caused vomiting and diarrhea. The acute phase was followed by polymorphonuclear cell infiltration, interleukin 8 induction, mononuclear cell recruitment, and the appearance of a specific antibody response against H. pylori. The chronic phase was characterized by gastritis, epithelial alterations, superficial erosions, and the appearance of the typical macroscopic follicles that in humans are considered possible precursors of MALT lymphoma. In conclusion, infection in this model mimics closely human infection and allows us to study those phases that cannot be studied in humans. This new model can be a unique tool for learning more about the disease and for developing strategies for treatment and prevention.
Subject(s)
Disease Models, Animal , Dogs , Helicobacter Infections , Helicobacter pylori , Acute Disease , Animals , Antibodies, Bacterial/immunology , Chronic Disease , Endoscopy, Gastrointestinal , Female , Helicobacter pylori/immunology , Helicobacter pylori/isolation & purification , Interleukin-8/metabolism , Male , MiceABSTRACT
The Authors evaluated clinical efficacy of nifedipine versus cymetropio bromide in relieving acute ureteral colic in 40 patients. Rapidity, efficacy and time of these drugs' activity in relieving pain of ureteral colic has been evaluated. The investigation shows as nifedipine relieves acute ureteral pain more quickly than cymetropio bromide (respectively 5 minutes in 95% of patients, 20 minutes in 65% of patients), but for a brief time (pain recurrence respectively in 70% and 25% of patients).
Subject(s)
Colic/drug therapy , Nifedipine/therapeutic use , Parasympatholytics/therapeutic use , Scopolamine Derivatives/therapeutic use , Ureteral Diseases/drug therapy , Adolescent , Adult , Child , Emergencies , Female , Humans , Male , Middle Aged , Remission Induction , Time FactorsABSTRACT
An amine oxidase activity distinguishable from MAO, which is inhibited by carbonyl reagents is present in rat epididymal WAT. This enzyme, referred to as semicarbazide-sensitive amine oxidase (SSAO), appears concentrated in adipose cells. Close homologies between WAT SSAO and the circulating plasma BAO are discussed.
