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J Vet Diagn Invest ; 32(6): 964-967, 2020 Nov.
Article in English | MEDLINE | ID: mdl-33000710

ABSTRACT

A 7-y-old mixed-breed male dog was presented with a history of generalized lymphadenopathy. Fine-needle aspirates of the enlarged peripheral lymph nodes were suggestive of lymphoma. Histologic examination of a retromandibular lymph node was suggestive of high-grade, medium large-cell lymphoma. Immunohistochemistry revealed concurrent expression of CD3 and CD20. The co-localization of the 2 antigens was confirmed by immunofluorescence. PCR for antigen receptor gene rearrangements (PARR) detected clonal rearrangements for both T-cell receptor gamma and B-cell receptor. The final diagnosis was CD3-CD20-positive anaplastic lymphoma with cross-lineage rearrangement.


Subject(s)
Antigens, CD20/genetics , CD3 Complex/genetics , Dog Diseases/diagnosis , Dog Diseases/genetics , Gene Rearrangement , Lymphoma, Large B-Cell, Diffuse/veterinary , Animals , Antigens, CD20/metabolism , CD3 Complex/metabolism , Dog Diseases/physiopathology , Dogs , Fluorescent Antibody Technique/veterinary , Immunohistochemistry , Lymph Nodes/pathology , Lymphoma, Large B-Cell, Diffuse/diagnosis , Lymphoma, Large B-Cell, Diffuse/genetics , Lymphoma, Large B-Cell, Diffuse/physiopathology , Male
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