Transcatheter repair of a large coronary pseudoaneurysm using ultrasound guidance and vein-covered stents.

This case-report describes a large pseudoaneurysm of the proximal left anterior descending coronary artery, fissured in the pericardium, developed 4 days after rotational and directional atherectomy followed by stent implantation. A successful percutaneous repair was obtained with 2 vein-covered stents implanted and expanded under ultrasound guidance.

[Pseudoaneurysm and aneurysm of the left ventricle. Discription of a case and long-term follow-up]. / Pseudoaneurisma e aneurisma del ventricolo sinistro. Descrizione di un caso e follow-up a lungo termine.

UNLABELLED: Left ventricle pseudoaneurysm is an uncommon complication of myocardial infarction; urgent operation is usually recommended, because of the high rate of severe complications. We report a single case with coexistence of a true aneurysm and a pseudoaneurysm, asymptomatic after three years of follow up in the absence of surgery. CASE REPORT: The patient, female, aged 69, was observed after an event of prolonged chest pain; ECG showed inferolateral necrosis. Echocardiographic examination showed: left ventricle enlargement with postero-lateral akinesis and septo-apical aneurysm, thin apical thrombosis and mild mitral regurgitation; a non-contractile concameration, aside of lateral wall, containing some thrombotic material and communicating with the left ventricle through a little hole (gap of echoes), crossed by a very little inflow jet. The diagnosis of coexisting septo-apical "true" aneurysm and postero-lateral pseudoaneurysm was confirmed with CT scan, NMR and left ventriculography. Coronary angiography showed total occlusion of LAD and a critical stenosis of mid LAD. The patient refused the operation. In 36 months follow-up no symptoms nor significant echocardiographic changes were observed. DISCUSSION: The pseudoaneurysm is caused by slow fissuration of the myocardium (after a myocardial infarction) with adhesion of pericardium and fibrosis, resulting in a saccular cavity, communicating with the left ventricle by a little hole; on the contrary the more frequent "true" aneurysm is a progressive dilatation and thinning of the ventricular wall, with parietal fibrotic degeneration. Echocardiography may be useful in differential diagnosis, but an excellent quality of the images is required and false negatives and positives are frequent. In this case the echocardiographic features include the thickness of the pseudoaneurysmal wall, the very low flow through the communication hole and the minimal mitralic involvement. CONCLUSION: This particular pattern, when accurately assessed, could probably be predictive of low risk and favorable prognosis in patients with pseudoaneurysm.

[An unusual case of "catecholamine necrosis" caused by accidental digitalis poisoning]. / Un raro caso di "necrosi catecolaminica" da intossicazione digitalica accidentale.

Toxic manifestations of digitalis are one of the most prevalent adverse drug reactions encountered in clinical practice. The estimated incidence is about 20% in hospitalized patients in the USA. The authors describe a rare case of myocardial "catecholamine necrosis" (anteroseptal myocardial infarction) during accidental digitalis intoxication. A male patient, 75 years old, suffering from cirrhosis and ascites, take on by mistake a tablet of digoxin 0.25 mg. four times at day for eleven days. He hadn't heart disease in the past. At the eleventh day the patient showed a deep tiredness and so he was submitted to a clinical examination and electrocardiogram. The ECG demonstrated an anteroseptal myocardial infarction in the second-third electrical stage. The patient was hospitalized. The successive examination revealed: very high plasma digitalis concentrations; an increase of the serum levels of CPK and LDH; a significant increase of plasmatic and urinary catecholamine levels which return to normal values after fifteen days; apical akinesia at the echocardiographic examination; no signs of residual myocardial ischemia to the echo-dypiridamole stress test; normal coronary artery to the coronary arteriography and absence of coronary artery spasm to the ergonovine test. Furthermore the abdominal echography and the abdominal computerized tomography didn't reveal surrenal disease but showed an important liver disease. The patient was free from other cardiac events in the follow-up. Generally, during the digitalis intoxication we observe various rhythm and conduction disturbances. Instead in this case no serious arrhythmias were registered and the main expression of the drug toxicity was an anteroseptal myocardial infarction with undamaged coronary artery. Also the usual extracardiac symptoms and signs of the digitalis intoxication were absent in this case. All these observations can be explained with the pathological increase of the cathecholamine levels, indirectly induced by digitalis; with the direct toxic effect of the drug at the myocardic level; with the contemporary absence of ionic disturbances; with the concomitant liver disease. The direct toxic effect of the digitalis produced an increase in calcium ions availability for the electromechanical coupling and an increase of the intramyocardial pressure; the increase of the adrenergic activity determined contemporary an increase in the oxygen consumption of the myocardial cells, a rise of vascular tone and coronary artery tone and a reduction of the duration of the diastole. All these factors provoked a "primary and secondary" ischemia which evolved toward a real "cathecholamine necrosis" and produced a myocardial infarction. This hypothesis explains the myocardial infarction in absence of injury at the coronary arteriography and without coronary spasm at the ergonovine test; moreover it explains the transient increase in cathecholamine plasma levels observed in the acute phases an normalized after fifteen days. The "cathecholamine necrosis" is an anatomical definition, nevertheless in our opinion it gives account of the rare clinical situation observed.

[Problem of false positives in dipyridamole-echocardiography test. Description of a case and review of the literature]. / Il problema dei falsi positivi nel test eco-dipiridamolo. Descrizione di un caso e revisione della letteratura.

Dipyridamole-echocardiography may be considered, at this time, an useful test not only in post-infarction risk stratification, but also in diagnosis and functional evaluation of coronary artery disease, having a satisfying sensibility (67%) and a very high specificity (96%). We report a particular case of "false positive" with a review of the literature. The patient, male, aged 45, without important risk factors for coronary artery disease, experimented recurrent events of spontaneous chest pain, typical per angina pectoris. Physical examination, chest roentgenogram and blood samples were normal. Slight signs of subendocardial ischemia, lateral, were present at ECG. Forced hyperpnea resulted in onset of chest pain, with increase of ECgraphic signs of ischemia; resolution of both was obtained with sublingual nitrate administration. A stress test with myocardial flow scintigraphic assessment using sestaMIBI, was performed: ECG showed significant ST downsloping at low workload (1-11 steps of Bruce protocol) and radionuclide tomography showed reversible hypoperfusion in anterior and septal regions. High dose dipyridamole-echocardiography test (a first bolus of 0.56 mg/kg in 4', followed after 4' by a second bolus of 0.28 mg/kg) gave these results: basal echocardiogram was normal; after first bolus of dipyridamole apical hypokinesia appeared; after second bolus complete akinesia was observed. ECG showed subendocardial injury wave and the patient experimented typical anginal pain. Clinical, electrocardiographic and echocardiographic changes were immediately reversed after intravenous bolus of aminophylline, 240 mgs. Coronary arteriography was performed: coronary arteries were angiographically normal, without even any marginal irregularity: left ventricle was normal in volume, wall kinesis and ejection fraction. Dipyridamole is a powerful ischemic stressor.(ABSTRACT TRUNCATED AT 250 WORDS)

[Calcitonin-induced anaphylactic shock. Case report and review of the literature]. / Shock anafilattico da calcitonina. Descrizione di un caso e revisione della letteratura.

A case of anaphylactic shock determined by intramuscular administration of a dose of synthetic calcitonin in a 64-years-old man is described. The patient had not suffered significant cardiovascular events in the past; he smoked twenty cigarettes a day and he was treated with calcitonin for osteoporosis and polyarthrosis. Allergy to diclofenac was demonstrated in the past while preceding administrations of spray calcification didn't provoke side-effects in the patient. Nevertheless after the second i.m. administration of the drug he suddenly fainted. Dyspnea, severe hypotension and maculo-papular erythema were present at the moment of admission to our hospital. The continuous electrocardiogram monitoring showed a characteristic "migrant" ST elevation at first in the anterior leads, then in inferior and septal leads, and premature ventricular and atrial beats. The echocardiographic transtoracic examination proved an apical and septal akinesia which completely disappeared after one hour at a second echocardiographic examination. In spite of intensive medical treatment (lignocaine and hydrocortisone e.v.) the patient had a sustained ventricular tachycardia that quickly degenerated into ventricular fibrillation. After one DC shock at 300 joules we observed spontaneous spontaneous restoration of the normal sinus rhythm. The following clinical evolution was good and no other arrhythmias or cardiovascular symptoms were observed. In order to estimate the reasons of the clinical picture the patient was submitted to serial blood examinations, serial electrocardiograms, exercise stress test, echodypiridamole stress test and serial echocardiograms. The blood examinations showed a relative eosynophilia (3%), the increase of IgE serum level (316 UI) and transient ipokalemia (2.3 mEq/l). None pathological findings were observed in the other examinations.(ABSTRACT TRUNCATED AT 250 WORDS)

[Color-Doppler echocardiography in electromechanical dissociation. Study of 2 cases]. / Ecocardiografia color-Doppler nella dissociazione elettromeccanica. Studio di 2 casi.

Electromechanical dissociation (EMD) is a condition of cardiac arrest occurring despite the persistence of apparently effective cardiac electric activity. Secondary EMDs are consequence of catastrophic circulatory failure (i.e. great vessel rupture, massive pulmonary embolism, cardiac tamponade), resulting in sudden and critical changes in hemodynamic load. Primary EMDs, on the other hand, occur in presence of intact circulatory system; they are known to be associated with global cardiac ischemia and contraction failure; however, the exact pathophysiologic change, triggering the onset of primary EMD, is still unknown. The current hypothesis of electromechanical uncoupling (a supposed derangement of excitation and contraction linking) has not been demonstrated. On the contrary, in a previous series of 22 2D-echocardiographic evaluations of patients with EMD, wall and valvular motion was visible in the majority of cases. In our Coronary Care Unit we had the opportunity to perform 2D and color-Doppler echocardiogram in 2 patients, developing primary EMD just while the examination was in course; we subsequently completed the examinations in the short pauses of cardio pulmonary resuscitation. Both patients died and necropsy showed in both cases recent large myocardial infarction, without hemopericardium. The analysis of the echocardiograms emphasized the presence of a residual cardiac mechanical activity: minimal segmental wall motion of left ventricle (LV); residual mitral valve motion, but no visible closure; diastolic low-velocity orthograde transmitralic flow; systolic regurgitant flow from LV to left atrium. On the other hand, we didn't observe any systolic flow directed to the LV outflow tract and to the aorta.(ABSTRACT TRUNCATED AT 250 WORDS)

[Acoustic, mechanical and electric alternans in heart tamponade. Clinical case and review of the literature]. / Alternanza acustica, meccanica ed elettrica nel tamponamento cardiaco. Caso clinico e revisione della letteratura.

The uncommon observation of alternation of the first heart sound in intensity, associated with mechanical and electric alternans is reported in a patient with cardiac tamponade due to large hemorrhagic pericardial effusion. Following pericardiocentesis and removal of 400 millilitres of fluid, all alternation phenomena disappeared. The combination of three alternation phenomena may be a helpful physical diagnostic sign of cardiac tamponade. The possible mechanisms of the "alternans" are discussed. It is suggested that variations in ventricular filling and emptying are the relevant pathogenetic factors.

Usefulness of xerotomography in the diagnosis of acute pulmonary embolism.

The Authors report their experience in the study of pulmonary embolism by xerotomography. The use of tomography for the study of pulmonary vascularization is well known, but this method is by far less frequently used than pulmonary angiography and pulmonary perfusion and ventilation scintigraphy. The enhancement of contrasts and contours and the ample area of exposure are the features which render the images obtained by xerotomography similar to those achieved by pulmonary angiography. Our experience up to the present time allows us to state that xerotomography may represent a valid diagnostic means in cases of acute pulmonary embolism, when scintigraphy is not feasible or following scintigraphy, when doubts regarding the clinical diagnosis still remain.