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1.
Lung ; 185(2): 89-96, 2007.
Article in English | MEDLINE | ID: mdl-17393237

ABSTRACT

Asthma is a chronic disease that may cause remodeling of the airways. We aimed to observe the effects of the combined use of inhaled budesonide and formoterol on both the reversibility of remodeling and structural changes in the airways. Thirty-six male patients (age range, 20-31) with mild-to-moderate persistent asthma were given inhaled formoterol and budesonide treatment for three months. Bronchial diameter (BD) and bronchial wall thickness (BWT), as measured by high-resolution computerized tomography, and reticular basement membrane thickness (RBMT), assessed in bronchoscopic biopsy specimens, were compared with pretreatment findings. Twenty-two age-matched male controls were also enrolled. BDs of the patients were significantly smaller than in the controls, whereas BWT and RBMT were greater. After three months BWT and RBMT of the subsegmental airways significantly decreased and BD increased. There was a prominent eosinophilic and lymphocytic infiltration in the bronchial mucosa of the asthmatics, and the eosinophilic infiltration significantly improved with treatment. Both serum total IgE and eosinophil counts were related to eosinophilic infiltration in the biopsy samples (r = 0.494 and r = 0.463, respectively). FEV(1) was positively correlated with the diameters of the segmental and subsegmental airways (r = 0.491 and r = 0.265, respectively) and negatively correlated with BWT of the subsegmental airways (r = -0.293) and with the RBMT of both the segmental and subsegmental airways (r = -0.597 and r = -0.590, respectively). We suggest that treatment with inhaled formoterol and budesonide may reverse increased RBMT and BWT as part of remodeling in patients with asthma.


Subject(s)
Asthma/drug therapy , Asthma/pathology , Bronchi/pathology , Bronchodilator Agents/therapeutic use , Budesonide/therapeutic use , Ethanolamines/therapeutic use , Administration, Inhalation , Adult , Asthma/diagnostic imaging , Basement Membrane/diagnostic imaging , Basement Membrane/pathology , Biopsy , Bronchodilator Agents/administration & dosage , Bronchography , Budesonide/administration & dosage , Dose-Response Relationship, Drug , Ethanolamines/administration & dosage , Forced Expiratory Volume/physiology , Formoterol Fumarate , Humans , Respiratory Mucosa/diagnostic imaging , Respiratory Mucosa/pathology , Time Factors , Tomography, X-Ray Computed
2.
Bull Cancer ; 91(6): E201-10, 2004 Jun.
Article in English | MEDLINE | ID: mdl-15562564

ABSTRACT

Lung cancer is still the most frequently seen malignancy among males where as females are less affected. Recently the lung cancer prevalence has been reported to increase among females in parallel to the increment in cigarette consumption. In our 2 clinic 11.2% (44 cases) of 393 primary lung cancer cases between 1993-1997 were female. We evaluated the demographical characteristics and yearly distribution of our female patients. Mean age was 64+/-12.1 and 18.2% of the patients were smokers. The main complaints were dyspnoea (59%), chest pain (57%), fatigue (47%), cough (45%)and sputum production (32%). The cell type distribution rates were as follows;adenocarcinoma 45.4%, squamous cell cancer 29.5%, small cell cancer 20.5% and large cell cancer 4.6%. The diagnostic methods used were sputum cytology (27.3%),transbronchial biopsy and lavage (38.6%), thoracocentesis and pleural biopsy (15.8%),transthoracic fine needle aspiration (13,6%) and open lung biopsy (4.7%). As a result,we found a low percentage of smokers but a high rate of adenocarcinomas among our female patients.


Subject(s)
Lung Neoplasms/epidemiology , Adenocarcinoma/epidemiology , Adenocarcinoma/pathology , Adult , Aged , Aged, 80 and over , Biopsy , Carcinoma, Large Cell/epidemiology , Carcinoma, Large Cell/pathology , Carcinoma, Small Cell/epidemiology , Carcinoma, Small Cell/pathology , Carcinoma, Squamous Cell/epidemiology , Carcinoma, Squamous Cell/pathology , Female , Humans , Incidence , Lung/pathology , Lung Neoplasms/pathology , Male , Middle Aged , Sex Distribution , Smoking/epidemiology
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