ABSTRACT
Groundwater and sandstone samples were analyzed for radon in Guarany aquifer, Paraná sedimentary basin, South America. The dissolved radon ranged between 3 and 3303pCi/l, being lognormally distributed, with a modal value of 1315pCi/l, and a median value of 330pCi/l. 222Rn leakage experiments for sandstones yielded a theoretical value of 1390pCi/l for 222Rn in water, showing that theoretical modeling can reliably be used to interpret laboratory and field data.
ABSTRACT
Forty patients suffering from asthmatic conditions, often accompanied by emphysema, were treated either with an extempore combination of salbutamol syrup plus 30-mg oxatomide tablets or with 30-mg oxatomide tablets alone for purposes of comparison. Greater efficacy was obtained with the combination, which produced positive results in terms of improved respiratory status, remission of clinical symptoms and reduced anti-asthma drug requirements in 90% of the cases treated, as against only 55% of satisfactory results obtained with oxatomide alone. The combination was very well tolerated with no incidence of adverse reactions, while the treatment with oxatomide alone, though on the whole well tolerated, gave rise to mild drowsiness in four cases.
Subject(s)
Albuterol/administration & dosage , Asthma/drug therapy , Histamine H1 Antagonists/administration & dosage , Piperazines/administration & dosage , Adrenal Cortex Hormones/therapeutic use , Adult , Aged , Asthma/complications , Asthma/physiopathology , Clinical Trials as Topic , Drug Combinations , Female , Humans , Male , Middle Aged , Pulmonary Emphysema/complications , Random Allocation , Respiratory Function Tests , Respiratory Therapy , Theophylline/therapeutic useABSTRACT
Carbohydrate intolerance with high insulin levels are a consistent finding in acute and chronic liver diseases. It has been recently clarified that in cirrhotic patients hyperinsulinism is related to decreased hepatic clearance, but the role of liver cell damage or portal systemic shuntings is still unclear. Therefore, we assessed glucose, immunoreactive insulin (IRI) and C-peptide immunoreactivity (CPR), in the basal state and after oral and intravenous glucose load, in fifteen patients with acute viral hepatitis (AVH), a liver disease where cell necrosis is prominent. CPR is a useful tool for investigation of hyperinsulinism as, according to previous reports, it is not - or is only to a limited degree - metabolised by the liver. Our results confirm the carbohydrate intolerance, with high IRI levels, in the early stage of AVH. CPR levels were significantly increased before and after glucose load. This study suggests that liver cell damage plays a key role in the pathogenesis of hyperinsulinism in liver diseases and high CPR values seem also to be related to liver damage.
